Jennifer Lippincott-Schwartz
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Lippincott-Schwartz's research revealed that the organelles of eukaryotic cells are dynamic, self-organized structures that constantly regenerate themselves through intracellular vesicle traffic, rather than static structures. She is also a pioneer in developing live cell imaging techniques to study the dynamic interactions of molecules in cells, including photobleaching and photoactivation techniques which allow investigation of subcellular localization, mobility, transport routes, and turnover of important cellular proteins related to membrane trafficking and compartmentalization. Lippincott-Schwartz's lab also tests mechanistic hypotheses related to protein and organelle functions and dynamics by utilizing quantitative measurements through kinetic modeling and simulation experiments. Along with Craig Blackstone, Lippincott-Schwartz utilized advanced imaging techniques to reveal a more accurate picture of how the peripheral endoplasmic reticulum is structured. Their findings may yield new insights for genetic diseases affecting proteins that help shape the endoplasmic reticulum. Additionally, Lippincott-Schwartz's laboratory demonstrated that Golgi enzymes constitutively recycle back to the endoplasmic reticulum and that such recycling plays a central role in the maintenance, biogenesis, and inheritance of the Golgi apparatus in mammalian cells.
Within Lippincott-Schwartz lab, current projects include several cell biological areas. For example, protein transport and cytoskeleton interaction, organelle assembly and disassembly, and cell polarity generation. There are also projects analyzing the dynamics of proteins that have been fluorescently labeled. These proteins are labeled using several live cell imaging techniques such as FRAP, FCS, and photoactivation.
Lippincott-Schwartz has dedicated her most recent lab research to photoactivation localization microscopy (PALM), which allows the viewing of molecular distributions of high densities at the nano-scale. Provided by Wikipedia
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6by Sun Woo Sophie Kang, Ghada Haydar, Caitlin Taniane, Geoffrey Farrell, Irwin M Arias, Jennifer Lippincott-Schwartz, Dong FuGet full text
Published 2016-01-01
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8by Arnold Y Seo, Pick-Wei Lau, Daniel Feliciano, Prabuddha Sengupta, Mark A Le Gros, Bertrand Cinquin, Carolyn A Larabell, Jennifer Lippincott-SchwartzGet full text
Published 2017-04-01
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11by Daniel Feliciano, Carolyn M. Ott, Isabel Espinosa-Medina, Aubrey V. Weigel, Lorena Benedetti, Kristin M. Milano, Zhonghua Tang, Tzumin Lee, Harvey J. Kliman, Seth M. Guller, Jennifer Lippincott-SchwartzGet full text
Published 2021-07-01
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12by Dvir Gur, Emily J. Bain, Kory R. Johnson, Andy J. Aman, H. Amalia Pasoili, Jessica D. Flynn, Michael C. Allen, Dimitri D. Deheyn, Jennifer C. Lee, Jennifer Lippincott-Schwartz, David M. ParichyGet full text
Published 2020-12-01
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14by Anitha P Govind, Okunola Jeyifous, Theron A Russell, Zola Yi, Aubrey V Weigel, Abhijit Ramaprasad, Luke Newell, William Ramos, Fernando M Valbuena, Jason C Casler, Jing-Zhi Yan, Benjamin S Glick, Geoffrey T Swanson, Jennifer Lippincott-Schwartz, William N GreenGet full text
Published 2021-09-01
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15by Anthony C. Cruz, Madhu Ramaswamy, Claudia Ouyang, Christopher A. Klebanoff, Prabuddha Sengupta, Tori N. Yamamoto, Françoise Meylan, Stacy K. Thomas, Nathan Richoz, Robert Eil, Susan Price, Rafael Casellas, V. Koneti Rao, Jennifer Lippincott-Schwartz, Nicholas P. Restifo, Richard M. SiegelGet full text
Published 2016-12-01
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16by Christopher J. Stefan, William S. Trimble, Sergio Grinstein, Guillaume Drin, Karin Reinisch, Pietro De Camilli, Sarah Cohen, Alex M. Valm, Jennifer Lippincott-Schwartz, Tim P. Levine, David B. Iaea, Frederick R. Maxfield, Clare E. Futter, Emily R. Eden, Delphine Judith, Alexander R. van Vliet, Patrizia Agostinis, Sharon A. Tooze, Ayumu Sugiura, Heidi M. McBrideGet full text
Published 2017-10-01
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