Origin of the omnipotence of eukaryotic release factor 1

by Christoffer Lind, Ana Oliveira, Johan Åqvist
Published 2017-11-01

Computer simulations explain the anomalous temperature optimum in a cold-adapted enzyme

by Jaka Sočan, Miha Purg, Johan Åqvist
Published 2020-05-01

Computational prediction of alanine scanning and ligand binding energetics in G-protein coupled receptors.

by Lars Boukharta, Hugo Gutiérrez-de-Terán, Johan Aqvist
Published 2014-04-01

Structural and energetic effects of A2A adenosine receptor mutations on agonist and antagonist binding.

by Henrik Keränen, Hugo Gutiérrez-de-Terán, Johan Åqvist
Published 2014-01-01

Protein surface softness is the origin of enzyme cold-adaptation of trypsin.

by Geir Villy Isaksen, Johan Åqvist, Bjørn Olav Brandsdal
Published 2014-08-01

QligFEP: an automated workflow for small molecule free energy calculations in Q

by Willem Jespers, Mauricio Esguerra, Johan Åqvist, Hugo Gutiérrez-de-Terán
Published 2019-04-01

Evolution of Angiotensin Peptides and Peptidomimetics as Angiotensin II Receptor Type 2 (AT2) Receptor Agonists

by Silvana Vasile, Anders Hallberg, Jessica Sallander, Mathias Hallberg, Johan Åqvist, Hugo Gutiérrez-de-Terán
Published 2020-04-01

Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Benzopyran-Based Inhibitors

by Sudarsana Reddy Vanga, Johan Åqvist, Anders Hallberg, Hugo Gutiérrez-de-Terán, Hugo Gutiérrez-de-Terán
Published 2021-04-01

Structure-Based Design of Potent and Selective Ligands at the Four Adenosine Receptors

by Willem Jespers, Ana Oliveira, Rubén Prieto-Díaz, María Majellaro, Johan Åqvist, Eddy Sotelo, Hugo Gutiérrez-de-Terán
Published 2017-11-01

Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides

by Sudarsana Reddy Vanga, Jonas Sävmarker, Leelee Ng, Mats Larhed, Mathias Hallberg, Johan Åqvist, Anders Hallberg, Siew Yeen Chai, Hugo Gutiérrez-de-Terán
Published 2018-04-01

The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site

by Anne Cathrine Nøhr, Willem Jespers, Mohamed A. Shehata, Leonard Floryan, Vignir Isberg, Kirsten Bayer Andersen, Johan Åqvist, Hugo Gutiérrez-de-Terán, Hans Bräuner-Osborne, David E. Gloriam
Published 2017-04-01

Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family

by Xiaohu Guo, Annika Söderholm, Sandesh Kanchugal P, Geir V Isaksen, Omar Warsi, Ulrich Eckhard, Silvia Trigüis, Adolf Gogoll, Jon Jerlström-Hultqvist, Johan Åqvist, Dan I Andersson, Maria Selmer
Published 2021-02-01

Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro‐Oxindole Dihydroquinazolinones as IRAP Inhibitors

by Karin Engen, Dr. Sudarsana Reddy Vanga, Dr. Thomas Lundbäck, Dr. Faith Agalo, Vivek Konda, Dr. Annika Jenmalm Jensen, Prof. Johan Åqvist, Dr. Hugo Gutiérrez‐de‐Terán, Prof. Dr. Mathias Hallberg, Prof. Dr. Mats Larhed, Dr. Ulrika Rosenström
Published 2020-03-01