Cutting down the time to identify challenging tumor therapeutic targets and drug combinations using synthetic lethal approaches [version 1; referees: 2 approved]

by John S. Lazo
Published 2018-03-01

The hubris and humility of cancer pharmacology in the post immuno‐oncology era

by John S. Lazo
Published 2019-12-01

Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer.

by Mark W Zimmerman, Gregg E Homanics, John S Lazo
Published 2013-01-01

Deletion of Ptp4a3 reduces clonogenicity and tumor-initiation ability of colitis-associated cancer cells in mice

by Julie M. Cramer, Mark W. Zimmerman, Tim Thompson, Gregg E. Homanics, John S. Lazo, Eric Lagasse
Published 2014-07-01

Effect of Pharmacological Inhibition of the Catalytic Activity of Phosphatases of Regenerating Liver in Early T Cell Receptor Signaling Dynamics and IL-2 Production

by Oscar Aguilar-Sopeña, Sara Hernández-Pérez, Sergio Alegre-Gómez, Patricia Castro-Sánchez, Alba Iglesias-Ceacero, John S. Lazo, Pedro Roda-Navarro
Published 2020-04-01

Strategies for Discovery of Small Molecule Radiation Protectors and Radiation Mitigators

by Joel S Greenberger, David eClump, Valerian eKagan, Hulya eBayir, John S Lazo, Peter eWipf, Song eLi, Xiang eGao, Michael Wayne Epperly
Published 2012-01-01

Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity.

by Elizabeth R Sharlow, Gabriela Mustata Wilson, David Close, Stephanie Leimgruber, Manuj Tandon, Robyn B Reed, Tong Ying Shun, Q Jane Wang, Peter Wipf, John S Lazo
Published 2011-01-01

Credentialing and Pharmacologically Targeting PTP4A3 Phosphatase as a Molecular Target for Ovarian Cancer

by John S. Lazo, Elizabeth R. Sharlow, Robert Cornelison, Duncan J. Hart, Danielle C. Llaneza, Anna J. Mendelson, Ettore J. Rastelli, Nikhil R. Tasker, Charles N. Landen, Peter Wipf
Published 2021-06-01

Design, Synthesis, and Biological Evaluation of PKD Inhibitors

by Marie-Céline Frantz, Karla Bravo-Altamirano, Courtney R. LaValle, Manuj Tandon, Stephanie Leimgruber, Elizabeth R. Sharlow, John S. Lazo, Q. Jane Wang, Peter Wipf, Kara M. George
Published 2011-04-01

Identification of potent chemotypes targeting Leishmania major using a high-throughput, low-stringency, computationally enhanced, small molecule screen.

by Elizabeth R Sharlow, David Close, Tongying Shun, Stephanie Leimgruber, Robyn Reed, Gabriela Mustata, Peter Wipf, Jacob Johnson, Michael O'Neil, Max Grögl, Alan J Magill, John S Lazo
Published 2009-11-01

A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity.

by Elizabeth R Sharlow, Todd A Lyda, Heidi C Dodson, Gabriela Mustata, Meredith T Morris, Stephanie S Leimgruber, Kuo-Hsiung Lee, Yoshiki Kashiwada, David Close, John S Lazo, James C Morris
Published 2010-04-01

Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z.

by Sager J Gosai, Joon Hyeok Kwak, Cliff J Luke, Olivia S Long, Dale E King, Kevin J Kovatch, Paul A Johnston, Tong Ying Shun, John S Lazo, David H Perlmutter, Gary A Silverman, Stephen C Pak
Published 2010-11-01