Gene therapy for the treatment of chronic peripheral nervous system pain

by William F. Goins, Justus B. Cohen, Joseph C. Glorioso
Published 2012-11-01

Herpes Simplex Virus Vectors for Gene Transfer to the Central Nervous System

by Sara Artusi, Yoshitaka Miyagawa, William F. Goins, Justus B. Cohen, Joseph C. Glorioso
Published 2018-08-01

Engineered HSV vector achieves safe long-term transgene expression in the central nervous system

by Gianluca Verlengia, Yoshitaka Miyagawa, Selene Ingusci, Justus B. Cohen, Michele Simonato, Joseph C. Glorioso
Published 2017-05-01

Generation of an Oncolytic Herpes Simplex Viral Vector Completely Retargeted to the GDNF Receptor GFRα1 for Specific Infection of Breast Cancer Cells

by Bonnie L. Hall, Daniela Leronni, Yoshitaka Miyagawa, William F. Goins, Joseph C. Glorioso, Justus B. Cohen
Published 2020-11-01

Deletion of the Virion Host Shut-off Gene Enhances Neuronal-Selective Transgene Expression from an HSV Vector Lacking Functional IE Genes

by Yoshitaka Miyagawa, Gianluca Verlengia, Bonnie Reinhart, Fang Han, Hiroaki Uchida, Silvia Zucchini, William F. Goins, Michele Simonato, Justus B. Cohen, Joseph C. Glorioso
Published 2017-09-01

Point Mutations in Retargeted gD Eliminate the Sensitivity of EGFR/EGFRvIII-Targeted HSV to Key Neutralizing Antibodies

by Ceren Tuzmen, Tina M. Cairns, Doina Atanasiu, Huan Lou, Wan Ting Saw, Bonnie L. Hall, Justus B. Cohen, Gary H. Cohen, Joseph C. Glorioso
Published 2020-03-01

An HSV-based library screen identifies PP1α as a negative TRPV1 regulator with analgesic activity in models of pain

by Bonnie Reinhart, William F Goins, Asaff Harel, Suchita Chaudhry, James R Goss, Naoki Yoshimura, William C de Groat, Justus B Cohen, Joseph C Glorioso
Published 2016-01-01

Inhibition of Indoleamine-2,3-dioxygenase (IDO) in Glioblastoma Cells by Oncolytic Herpes Simplex Virus

by Bonnie Reinhart, Lucia Mazzacurati, Adriana Forero, Chang-Sook Hong, Junichi Eguchi, Hideho Okada, Wendy Fellows, Ajay Niranjan, Justus B. Cohen, Joseph C. Glorioso, Paola Grandi
Published 2012-01-01

Protocol Optimization for the Production of the Non-Cytotoxic JΔNI5 HSV Vector Deficient in Expression of Immediately Early Genes

by Seiji Kuroda, Yoshitaka Miyagawa, Yuriko Sato, Motoko Yamamoto, Kumi Adachi, Hiromi Kinoh, William F. Goins, Justus B. Cohen, Joseph C. Glorioso, Nobuhiko Taniai, Hiroshi Yoshida, Takashi Okada
Published 2020-06-01

Treatment of glioblastoma with current oHSV variants reveals differences in efficacy and immune cell recruitment

by Joseph W. Jackson, Bonnie L. Hall, Marco Marzulli, Vrusha K. Shah, Lisa Bailey, E. Antonio Chiocca, William F. Goins, Gary Kohanbash, Justus B. Cohen, Joseph C. Glorioso
Published 2021-09-01

GBM-Targeted oHSV Armed with Matrix Metalloproteinase 9 Enhances Anti-tumor Activity and Animal Survival

by Paola Sette, Nduka Amankulor, Aofei Li, Marco Marzulli, Daniela Leronni, Mingdi Zhang, William F. Goins, Balveen Kaur, Chelsea Bolyard, Timothy P. Cripe, Jianhua Yu, E. Antonio Chiocca, Joseph C. Glorioso, Paola Grandi
Published 2019-12-01

Design of an Interferon-Resistant Oncolytic HSV-1 Incorporating Redundant Safety Modalities for Improved Tolerability

by Edward M. Kennedy, Terry Farkaly, Peter Grzesik, Jennifer Lee, Agnieszka Denslow, Jacqueline Hewett, Jeffrey Bryant, Prajna Behara, Caitlin Goshert, Daniel Wambua, Ana De Almeida, Judith Jacques, Damian Deavall, James B. Rottman, Joseph C. Glorioso, Mitchell H. Finer, Brian B. Haines, Christophe Quéva, Lorena Lerner
Published 2020-09-01

Oncolytic HSV virotherapy in murine sarcomas differentially triggers an antitumor T-cell response in the absence of virus permissivity

by Jennifer L Leddon, Chun-Yu Chen, Mark A Currier, Pin-Yi Wang, Francesca A Jung, Nicholas L Denton, Kevin M Cripe, Kellie B Haworth, Michael A Arnold, Amy C Gross, Timothy D Eubank, William F Goins, Joseph C Glorioso, Justus B Cohen, Paola Grandi, David A Hildeman, Timothy P Cripe
Published 2014-01-01