Understanding and Exploiting the Effect of Tuberculosis Antimicrobials on Host Mitochondrial Function and Bioenergetics

by Christina Cahill, James Joseph Phelan, Joseph Keane
Published 2020-09-01

Editorial: Molecular Mechanisms and New Therapeutic Targets in Epithelial to Mesenchymal Transition (EMT) and Fibrosis

by Cecilia Battistelli, Marc Diederich, Timothy Joseph Keane, Pilar Sandoval, Sergio Valente, Raffaele Strippoli, Raffaele Strippoli
Published 2020-01-01

Modulating Iron for Metabolic Support of TB Host Defense

by James J. Phelan, Sharee A. Basdeo, Simone C. Tazoll, Sadhbh McGivern, Judit R. Saborido, Joseph Keane
Published 2018-10-01

The Warburg Effect Occurs Rapidly in Stimulated Human Adult but Not Umbilical Cord Blood Derived Macrophages

by Cilian Ó Maoldomhnaigh, Donal J. Cox, James J. Phelan, Fergal D. Malone, Joseph Keane, Sharee A. Basdeo
Published 2021-04-01

Epigenetic induction of CD1d expression primes lung cancer cells for killing by invariant natural killer T cells

by Éilis Dockry, Seónadh O'Leary, Laura E. Gleeson, Judith Lyons, Joseph Keane, Steven G. Gray, Derek G. Doherty
Published 2018-06-01

Treatment of Mycobacterium tuberculosis-Infected Macrophages with Poly(Lactic-Co-Glycolic Acid) Microparticles Drives NFκB and Autophagy Dependent Bacillary Killing.

by Ciaran Lawlor, Gemma O'Connor, Seonadh O'Leary, Paul J Gallagher, Sally-Ann Cryan, Joseph Keane, Mary P O'Sullivan
Published 2016-01-01

Inhibiting Histone Deacetylases in Human Macrophages Promotes Glycolysis, IL-1β, and T Helper Cell Responses to Mycobacterium tuberculosis

by Donal J. Cox, Amy M. Coleman, Karl M. Gogan, James J. Phelan, Cilian Ó Maoldomhnaigh, Pádraic J. Dunne, Sharee A. Basdeo, Joseph Keane
Published 2020-07-01

Networked T cell death following macrophage infection by Mycobacterium tuberculosis.

by Stephen H-F Macdonald, Elliott Woodward, Michelle M Coleman, Emma R Dorris, Parthiban Nadarajan, Wui-Mei Chew, Anne-Marie McLaughlin, Joseph Keane
Published 2012-01-01

Interferon gamma release assays for the diagnosis of latent TB infection in HIV-infected individuals in a low TB burden country.

by Clíona Ní Cheallaigh, Ian Fitzgerald, Jacinta Grace, Gurmit Jagjit Singh, Nahla El-Eraki, Noel Gibbons, Joseph Keane, Thomas R Rogers, Susan Clarke, Colm Bergin
Published 2013-01-01

The Iron Chelator Desferrioxamine Increases the Efficacy of Bedaquiline in Primary Human Macrophages Infected with BCG

by Christina Cahill, Fiona O’Connell, Karl M. Gogan, Donal J. Cox, Sharee A. Basdeo, Jacintha O’Sullivan, Stephen V. Gordon, Joseph Keane, James J. Phelan
Published 2021-03-01

Lactate Alters Metabolism in Human Macrophages and Improves Their Ability to Kill Mycobacterium tuberculosis

by Cilian Ó Maoldomhnaigh, Donal J. Cox, James J. Phelan, Morgane Mitermite, Dearbhla M. Murphy, Gina Leisching, Lorraine Thong, Seónadh M. O’Leary, Karl M. Gogan, Kate McQuaid, Amy M. Coleman, Stephen V. Gordon, Sharee A. Basdeo, Joseph Keane
Published 2021-10-01

Desferrioxamine Supports Metabolic Function in Primary Human Macrophages Infected With Mycobacterium tuberculosis

by James Joseph Phelan, Kate McQuaid, Colin Kenny, Karl Michael Gogan, Dónal J. Cox, Sharee Ann Basdeo, Seónadh O’Leary, Simone Christa Tazoll, Cilian Ó Maoldomhnaigh, Mary P. O’Sullivan, Luke A. O’Neill, Maureen J. O’Sullivan, Joseph Keane
Published 2020-05-01

A TNF-regulated recombinatorial macrophage immune receptor implicated in granuloma formation in tuberculosis.

by Alexander W Beham, Kerstin Puellmann, Rebecca Laird, Tina Fuchs, Roswita Streich, Caroline Breysach, Dirk Raddatz, Septimia Oniga, Teresa Peccerella, Peter Findeisen, Julia Kzhyshkowska, Alexei Gratchev, Stefan Schweyer, Bernadette Saunders, Johannes T Wessels, Wiebke Möbius, Joseph Keane, Heinz Becker, Arnold Ganser, Michael Neumaier, Wolfgang E Kaminski
Published 2011-11-01

Mycobacterium tuberculosis Limits Host Glycolysis and IL-1β by Restriction of PFK-M via MicroRNA-21

by Emer E. Hackett, Hugo Charles-Messance, Seónadh M. O’Leary, Laura E. Gleeson, Natalia Muñoz-Wolf, Sarah Case, Anna Wedderburn, Daniel G.W. Johnston, Michelle A. Williams, Alicia Smyth, Mireille Ouimet, Kathryn J. Moore, Ed C. Lavelle, Sinéad C. Corr, Stephen V. Gordon, Joseph Keane, Frederick J. Sheedy
Published 2020-01-01