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Joseph L. Goldstein
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Joseph L. Goldstein
Joseph L. Goldstein
Joseph Leonard Goldstein
ForMemRS
(born April 18, 1940) is an American
biochemist
. He received the
Nobel Prize in Physiology or Medicine
in 1985, along with fellow
University of Texas Southwestern
researcher,
Michael Brown
, for their studies regarding
cholesterol
. They discovered that human cells have
low-density lipoprotein
(LDL) receptors that remove
cholesterol
from the blood and that when
LDL receptor
s are not present in sufficient numbers, individuals develop
hypercholesterolemia
and become at risk for cholesterol related diseases, notably
coronary heart disease
. Their studies led to the development of
statin
drugs.
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Joseph L. Goldstein
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1
Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL
by
Michael S. Brown
,
Joseph
L
.
Goldstein
Published 2009-01-01
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Article
2
Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1
by
Michael Nguyen Trinh
,
Michael S Brown
,
Joachim Seemann
,
Joseph
L
Goldstein
,
Feiran Lu
Published 2018-07-01
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Article
3
Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis
by
Akash Das
,
Michael S Brown
,
Donald D Anderson
,
Joseph
L
Goldstein
,
Arun Radhakrishnan
Published 2014-06-01
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Article
4
BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver
by
Jing Tian
,
Jiaxi Wu
,
Xiang Chen
,
Tong Guo
,
Zhijian J Chen
,
Joseph
L
Goldstein
,
Michael S Brown
Published 2018-06-01
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Article
5
Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection
by
Feiran Lu
,
Qiren Liang
,
Lina Abi-Mosleh
,
Akash Das
,
Jef K De Brabander
,
Joseph
L
Goldstein
,
Michael S Brown
Published 2015-12-01
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Article
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