Chapter 13: Mining electronic health records in the genomics era.

by Joshua C Denny
Published 2012-01-01

Correction: Computational Phenotype Discovery Using Unsupervised Feature Learning over Noisy, Sparse, and Irregular Clinical Data

by Thomas A. Lasko, Joshua C. Denny, Mia A. Levy
Published 2013-01-01

Correction: Computational Phenotype Discovery Using Unsupervised Feature Learning over Noisy, Sparse, and Irregular Clinical Data.

by Thomas A. Lasko, Joshua C. Denny, Mia A. Levy
Published 2013-01-01

Computational phenotype discovery using unsupervised feature learning over noisy, sparse, and irregular clinical data.

by Thomas A Lasko, Joshua C Denny, Mia A Levy
Published 2013-01-01

An integrative functional genomics framework for effective identification of novel regulatory variants in genome–phenome studies

by Junfei Zhao, Feixiong Cheng, Peilin Jia, Nancy Cox, Joshua C. Denny, Zhongming Zhao
Published 2018-01-01

Phenome-wide association study identifies marked increased in burden of comorbidities in African Americans with systemic lupus erythematosus

by April Barnado, Robert J. Carroll, Carolyn Casey, Lee Wheless, Joshua C. Denny, Leslie J. Crofford
Published 2018-04-01

Cox regression increases power to detect genotype-phenotype associations in genomic studies using the electronic health record

by Jacob J. Hughey, Seth D. Rhoades, Darwin Y. Fu, Lisa Bastarache, Joshua C. Denny, Qingxia Chen
Published 2019-11-01

Using topic modeling via non-negative matrix factorization to identify relationships between genetic variants and disease phenotypes: A case study of Lipoprotein(a) (LPA).

by Juan Zhao, QiPing Feng, Patrick Wu, Jeremy L Warner, Joshua C Denny, Wei-Qi Wei
Published 2019-01-01

Correction: Enabling Genomic-Phenomic Association Discovery without Sacrificing Anonymity.

by Raymond D Heatherly, Grigorios Loukides, Joshua C Denny, Jonathan L Haines, Dan M Roden, Bradley A Malin
Published 2013-01-01

Enabling genomic-phenomic association discovery without sacrificing anonymity.

by Raymond D Heatherly, Grigorios Loukides, Joshua C Denny, Jonathan L Haines, Dan M Roden, Bradley A Malin
Published 2013-01-01

Translational Health Disparities Research in a Data-Rich World

by Nancy Breen, David Berrigan, James S. Jackson, David W.S. Wong, Frederick B. Wood, Joshua C. Denny, Xinzhi Zhang, Philip E. Bourne
Published 2019-11-01

An active learning-enabled annotation system for clinical named entity recognition

by Yukun Chen, Thomas A. Lask, Qiaozhu Mei, Qingxia Chen, Sungrim Moon, Jingqi Wang, Ky Nguyen, Tolulola Dawodu, Trevor Cohen, Joshua C. Denny, Hua Xu
Published 2017-07-01

Evaluating phecodes, clinical classification software, and ICD-9-CM codes for phenome-wide association studies in the electronic health record.

by Wei-Qi Wei, Lisa A Bastarache, Robert J Carroll, Joy E Marlo, Travis J Osterman, Eric R Gamazon, Nancy J Cox, Dan M Roden, Joshua C Denny
Published 2017-01-01

Deciphering Signaling Pathway Networks to Understand the Molecular Mechanisms of Metformin Action.

by Jingchun Sun, Min Zhao, Peilin Jia, Lily Wang, Yonghui Wu, Carissa Iverson, Yubo Zhou, Erica Bowton, Dan M Roden, Joshua C Denny, Melinda C Aldrich, Hua Xu, Zhongming Zhao
Published 2015-06-01

LabWAS: Novel findings and study design recommendations from a meta-analysis of clinical labs in two independent biobanks.

by Jeffery A Goldstein, Joshua S Weinstock, Lisa A Bastarache, Daniel B Larach, Lars G Fritsche, Ellen M Schmidt, Chad M Brummett, Sachin Kheterpal, Goncalo R Abecasis, Joshua C Denny, Matthew Zawistowski
Published 2020-11-01

Comparison of HLA allelic imputation programs.

by Jason H Karnes, Christian M Shaffer, Lisa Bastarache, Silvana Gaudieri, Andrew M Glazer, Heidi E Steiner, Jonathan D Mosley, Simon Mallal, Joshua C Denny, Elizabeth J Phillips, Dan M Roden
Published 2017-01-01

eMERGEing progress in genomics---the first seven years

by Dana C. Crawford, Dana C. Crawford, David R. Crosslin, David R. Crosslin, Gerard eTromp, Iftikhar J. Kullo, Helena eKuivaniemi, M. Geoffrey Hayes, Joshua C. Denny, Joshua C. Denny, William Scott Bush, William Scott Bush, Jonathan L. Haines, Jonathan L. Haines, Dan M. Roden, Dan M. Roden, Catherine Anne McCarty, Gail P. Jarvik, Gail P. Jarvik, Marylyn D. Ritchie, Marylyn D. Ritchie
Published 2014-06-01

A Decision-Theoretic Approach to Panel-Based, Preemptive Genotyping

by Yaping Shi, John A. Graves, Shawn P. Garbett, Zilu Zhou, Ramya Marathi, Xiaoming Wang, Frank E. Harrell, Thomas A. Lasko, Joshua C. Denny, Dan M. Roden, Josh F. Peterson, Jonathan S. Schildcrout
Published 2019-08-01

Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks.

by Stephen D Turner, Richard L Berg, James G Linneman, Peggy L Peissig, Dana C Crawford, Joshua C Denny, Dan M Roden, Catherine A McCarty, Marylyn D Ritchie, Russell A Wilke
Published 2011-05-01

Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization study.

by Xue Li, Xiangrui Meng, Yazhou He, Athina Spiliopoulou, Maria Timofeeva, Wei-Qi Wei, Aliya Gifford, Tian Yang, Tim Varley, Ioanna Tzoulaki, Peter Joshi, Joshua C Denny, Paul Mckeigue, Harry Campbell, Evropi Theodoratou
Published 2019-10-01