Lurbinectedin synergizes with immune checkpoint blockade to generate anticancer immunity

by Wei Xie, Sabrina Forveille, Kristina Iribarren, Allan Sauvat, Laura Senovilla, Yan Wang, Juliette Humeau, Maria Perez-Lanzon, Heng Zhou, Juan F. Martínez-Leal, Guido Kroemer, Oliver Kepp
Published 2019-11-01

Specific Effects of Trabectedin and Lurbinectedin on Human Macrophage Function and Fate—Novel Insights

by Adrián Povo-Retana, Marina Mojena, Adrian B. Stremtan, Victoria B. Fernández-García, Ana Gómez-Sáez, Cristina Nuevo-Tapioles, José M. Molina-Guijarro, José Avendaño-Ortiz, José M. Cuezva, Eduardo López-Collazo, Juan F. Martínez-Leal, Lisardo Boscá
Published 2020-10-01

Irvalec inserts into the plasma membrane causing rapid loss of integrity and necrotic cell death in tumor cells.

by José M Molina-Guijarro, Álvaro Macías, Carolina García, Eva Muñoz, Luis F García-Fernández, Miren David, Lucía Núñez, Juan F Martínez-Leal, Victoria Moneo, Carmen Cuevas, M Pilar Lillo, Carlos Villalobos Jorge, Carmen Valenzuela, Carlos M Galmarini
Published 2011-04-01