Targeting the Activin Receptor Signaling to Counteract the Multi-Systemic Complications of Cancer and Its Treatments

by Juha J. Hulmi, Tuuli A. Nissinen, Fabio Penna, Andrea Bonetto
Published 2021-02-01

Activin Receptor Ligand Blocking and Cancer Have Distinct Effects on Protein and Redox Homeostasis in Skeletal Muscle and Liver

by Jaakko Hentilä, Tuuli A. Nissinen, Ayhan Korkmaz, Sanna Lensu, Mika Silvennoinen, Arja Pasternack, Olli Ritvos, Mustafa Atalay, Juha J. Hulmi, Juha J. Hulmi
Published 2019-01-01

Differentiation of Murine C2C12 Myoblasts Strongly Reduces the Effects of Myostatin on Intracellular Signaling

by Juulia H. Lautaoja, Satu Pekkala, Arja Pasternack, Mika Laitinen, Olli Ritvos, Juha J. Hulmi
Published 2020-04-01

Blocking Activin Receptor Ligands Is Not Sufficient to Rescue Cancer-Associated Gut Microbiota—A Role for Gut Microbial Flagellin in Colorectal Cancer and Cachexia?

by Satu Pekkala, Anniina Keskitalo, Emilia Kettunen, Sanna Lensu, Noora Nykänen, Teijo Kuopio, Olli Ritvos, Jaakko Hentilä, Tuuli A. Nissinen, Juha J. Hulmi
Published 2019-11-01

Treating cachexia using soluble ACVR2B improves survival, alters mTOR localization, and attenuates liver and spleen responses

by Tuuli A. Nissinen, Jaakko Hentilä, Fabio Penna, Anita Lampinen, Juulia H. Lautaoja, Vasco Fachada, Tanja Holopainen, Olli Ritvos, Riikka Kivelä, Juha J. Hulmi
Published 2018-06-01

Prevention of chemotherapy‐induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle

by Juha J. Hulmi, Tuuli A. Nissinen, Markus Räsänen, Joni Degerman, Juulia H. Lautaoja, Karthik Amudhala Hemanthakumar, Janne T. Backman, Olli Ritvos, Mika Silvennoinen, Riikka Kivelä
Published 2018-04-01

Molecular Pathways Mediating Immunosuppression in Response to Prolonged Intensive Physical Training, Low-Energy Availability, and Intensive Weight Loss

by Heikki V. Sarin, Heikki V. Sarin, Ivan Gudelj, Jarno Honkanen, Jarno Honkanen, Johanna K. Ihalainen, Johanna K. Ihalainen, Arja Vuorela, Joseph H. Lee, Zhenzhen Jin, Joseph D. Terwilliger, Ville Isola, Juha P. Ahtiainen, Keijo Häkkinen, Julija Jurić, Gordan Lauc, Gordan Lauc, Kati Kristiansson, Kati Kristiansson, Juha J. Hulmi, Juha J. Hulmi, Markus Perola, Markus Perola
Published 2019-05-01

VEGF‐B‐induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart

by Riikka Kivelä, Maija Bry, Marius R Robciuc, Markus Räsänen, Miia Taavitsainen, Johanna MU Silvola, Antti Saraste, Juha J Hulmi, Andrey Anisimov, Mikko I Mäyränpää, Jan H Lindeman, Lauri Eklund, Sanna Hellberg, Ruslan Hlushchuk, Zhen W Zhuang, Michael Simons, Valentin Djonov, Juhani Knuuti, Eero Mervaala, Kari Alitalo
Published 2014-03-01