Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15

by Juli E. Jones, Samuel M. Cadena, Chenguang Gong, Xiaomei Wang, Zhiping Chen, Sharon X. Wang, Chad Vickers, Hong Chen, Estelle Lach-Trifilieff, John R. Hadcock, David J. Glass
Published 2018-02-01

Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15

by Juli E. Jones, Samuel M. Cadena, Chenguang Gong, Xiaomei Wang, Zhiping Chen, Sharon X. Wang, Chad Vickers, Hong Chen, Estelle Lach-Trifilieff, John R. Hadcock, David J. Glass
Published 2018-03-01

The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in the central nervous system

by Susana S. Correia, Guang Liu, Sarah Jacobson, Sylvie G. Bernier, Jenny V. Tobin, Chad D. Schwartzkopf, Emily Atwater, Elisabeth Lonie, Sam Rivers, Andrew Carvalho, Peter Germano, Kim Tang, Rajesh R. Iyengar, Mark G. Currie, John R. Hadcock, Christopher J. Winrow, Juli E. Jones
Published 2021-09-01

The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases

by Susana S. Correia, Rajesh R. Iyengar, Peter Germano, Kim Tang, Sylvie G. Bernier, Chad D. Schwartzkopf, Jenny Tobin, Thomas W.-H. Lee, Guang Liu, Sarah Jacobson, Andrew Carvalho, Glen R. Rennie, Joon Jung, Paul A. Renhowe, Elisabeth Lonie, Christopher J. Winrow, John R. Hadcock, Juli E. Jones, Mark G. Currie
Published 2021-05-01

Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease

by Daniel P. Zimmer, Courtney M. Shea, Jenny V. Tobin, Boris Tchernychev, Peter Germano, Kristie Sykes, Ali R. Banijamali, Sarah Jacobson, Sylvie G. Bernier, Renee Sarno, Andrew Carvalho, Yueh-tyng Chien, Regina Graul, Emmanuel S. Buys, Juli E. Jones, James D. Wakefield, Gavrielle M. Price, Jennifer G. Chickering, G. Todd Milne, Mark G. Currie, Jaime L. Masferrer
Published 2020-04-01