Molecular Connectivity Predefines Polypharmacology: Aliphatic Rings, Chirality, and sp3 Centers Enhance Target Selectivity

by Stefania Monteleone, Julian E. Fuchs, Klaus R. Liedl
Published 2017-08-01

Substrate-driven mapping of the degradome by comparison of sequence logos.

by Julian E Fuchs, Susanne von Grafenstein, Roland G Huber, Christian Kramer, Klaus R Liedl
Published 2013-01-01

Conformational Flexibility Differentiates Naturally Occurring Bet v 1 Isoforms

by Sarina Grutsch, Julian E. Fuchs, Linda Ahammer, Anna S. Kamenik, Klaus R. Liedl, Martin Tollinger
Published 2017-06-01

Characterizing Protease Specificity: How Many Substrates Do We Need?

by Michael Schauperl, Julian E Fuchs, Birgit J Waldner, Roland G Huber, Christian Kramer, Klaus R Liedl
Published 2015-01-01

Dynamics Govern Specificity of a Protein-Protein Interface: Substrate Recognition by Thrombin.

by Julian E Fuchs, Roland G Huber, Birgit J Waldner, Ursula Kahler, Susanne von Grafenstein, Christian Kramer, Klaus R Liedl
Published 2015-01-01

Dynamic regulation of phenylalanine hydroxylase by simulated redox manipulation.

by Julian E Fuchs, Roland G Huber, Susanne von Grafenstein, Hannes G Wallnoefer, Gudrun M Spitzer, Dietmar Fuchs, Klaus R Liedl
Published 2012-01-01

Cleavage entropy as quantitative measure of protease specificity.

by Julian E Fuchs, Susanne von Grafenstein, Roland G Huber, Michael A Margreiter, Gudrun M Spitzer, Hannes G Wallnoefer, Klaus R Liedl
Published 2013-04-01

Pharmacological Targets of Kaempferol Within Inflammatory Pathways—A Hint Towards the Central Role of Tryptophan Metabolism

by Stefanie Hofer, Simon Geisler, Rebecca Lisandrelli, Hieu Nguyen Ngoc, Markus Ganzera, Harald Schennach, Dietmar Fuchs, Julian E. Fuchs, Johanna M. Gostner, Katharina Kurz
Published 2020-02-01

A One Pot Synthesis of Novel Bioactive Tri-Substitute-Condensed-Imidazopyridines that Targets Snake Venom Phospholipase A2.

by Nirvanappa C Anilkumar, Mahalingam S Sundaram, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Krishna C Bulusu, Julian E Fuchs, Kesturu S Girish, Andreas Bender, Basappa, Kanchugarakoppal S Rangappa
Published 2015-01-01

Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity

by C. P. Baburajeev, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Daniel J. Mason, Julian E. Fuchs, Andreas Bender, Uri Barash, Israel Vlodavsky, Basappa, Kanchugarakoppal S. Rangappa
Published 2017-03-01

A Nano-MgO and Ionic Liquid-Catalyzed 'Green' Synthesis Protocol for the Development of Adamantyl-Imidazolo-Thiadiazoles as Anti-Tuberculosis Agents Targeting Sterol 14α-Demethylas...

by Sebastian Anusha, Baburajeev Cp, Chakrabhavi Dhananjaya Mohan, Jessin Mathai, Shobith Rangappa, Surender Mohan, Chandra, Shardul Paricharak, Lewis Mervin, Julian E Fuchs, Mahedra M, Andreas Bender, Basappa, Kanchugarakoppal S Rangappa
Published 2015-01-01

A Cross-Reactive Human Single-Chain Antibody for Detection of Major Fish Allergens, Parvalbumins, and Identification of a Major IgE-Binding Epitope.

by Merima Bublin, Maria Kostadinova, Julian E Fuchs, Daniela Ackerbauer, Adolfo H Moraes, Fabio C L Almeida, Nina Lengger, Christine Hafner, Christof Ebner, Christian Radauer, Klaus R Liedl, Ana Paula Valente, Heimo Breiteneder
Published 2015-01-01

The impact of nitration on the structure and immunogenicity of the major birch pollen allergen Bet v 1.0101.

by Chloé Ackaert, Stefan Kofler, Jutta Horejs-Hoeck, Nora Zulehner, Claudia Asam, Susanne von Grafenstein, Julian E Fuchs, Peter Briza, Klaus R Liedl, Barbara Bohle, Fátima Ferreira, Hans Brandstetter, Gertie J Oostingh, Albert Duschl
Published 2014-01-01

Novel Adamantanyl-Based Thiadiazolyl Pyrazoles Targeting EGFR in Triple-Negative Breast Cancer

by Anusha Sebastian, Vijay Pandey, Chakrabhavi Dhananjaya Mohan, Yi Ting Chia, Shobith Rangappa, Jessin Mathai, C. P. Baburajeev, Shardul Paricharak, Lewis H. Mervin, Krishna C. Bulusu, Julian E. Fuchs, Andreas Bender, Shuhei Yamada, Basappa, Peter E. Lobie, Kanchugarakoppal S. Rangappa
Published 2016-12-01