Sonlicromanol's active metabolite KH176m normalizes prostate cancer stem cell mPGES-1 overexpression and inhibits cancer spheroid growth.

by Xiaolan Jiang, Herma Renkema, Jan Smeitink, Julien Beyrath
Published 2021-01-01

Feeding difficulties, a key feature of the Drosophila NDUFS4 mitochondrial disease model

by Sarah Foriel, Julien Beyrath, Ilse Eidhof, Richard J. Rodenburg, Annette Schenck, Jan A. M. Smeitink
Published 2018-03-01

KH176 under development for rare mitochondrial disease: a first in man randomized controlled clinical trial in healthy male volunteers

by Saskia Koene, Edwin Spaans, Luc Van Bortel, Griet Van Lancker, Brant Delafontaine, Fabio Badilini, Julien Beyrath, Jan Smeitink
Published 2017-10-01

Oxidative switch drives mitophagy defects in dopaminergic parkin mutant patient neurons

by Aurelie Schwartzentruber, Camilla Boschian, Fernanda Martins Lopes, Monika A. Myszczynska, Elizabeth J. New, Julien Beyrath, Jan Smeitink, Laura Ferraiuolo, Heather Mortiboys
Published 2020-09-01

Live-Imaging Readouts and Cell Models for Phenotypic Profiling of Mitochondrial Function

by Eligio F. Iannetti, Eligio F. Iannetti, Alessandro Prigione, Jan A. M. Smeitink, Jan A. M. Smeitink, Werner J. H. Koopman, Julien Beyrath, Herma Renkema
Published 2019-03-01

A Drosophila Mitochondrial Complex I Deficiency Phenotype Array

by Sarah Foriel, Sarah Foriel, G. Herma Renkema, G. Herma Renkema, Yvonne Lasarzewski, Job Berkhout, Richard J. Rodenburg, Jan A. M. Smeitink, Jan A. M. Smeitink, Julien Beyrath, Annette Schenck
Published 2019-03-01