Surrogate R-spondins for tissue-specific potentiation of Wnt Signaling.

by Vincent C Luca, Yi Miao, Xingnan Li, Michael J Hollander, Calvin J Kuo, K Christopher Garcia
Published 2020-01-01

Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers

by Ignacio Moraga, Jamie B Spangler, Juan L Mendoza, Milica Gakovic, Tom S Wehrman, Peter Krutzik, K Christopher Garcia
Published 2017-05-01

Simplified, enhanced protein purification using an inducible, autoprocessing enzyme tag.

by Aimee Shen, Patrick J Lupardus, Montse Morell, Elizabeth L Ponder, A Masoud Sadaghiani, K Christopher Garcia, Matthew Bogyo
Published 2009-12-01

A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Specific Regulation of Wnt Bioavailability

by Mario Vallon, Kanako Yuki, Thi D. Nguyen, Junlei Chang, Jenny Yuan, Dirk Siepe, Yi Miao, Markus Essler, Makoto Noda, K. Christopher Garcia, Calvin J. Kuo
Published 2018-10-01

Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling

by Naotaka Tsutsumi, Somnath Mukherjee, Deepa Waghray, Claudia Y Janda, Kevin M Jude, Yi Miao, John S Burg, Nanda Gowtham Aduri, Anthony A Kossiakoff, Cornelius Gati, K Christopher Garcia
Published 2020-08-01

Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance.

by Kalliopi Pervolaraki, Soheil Rastgou Talemi, Dorothee Albrecht, Felix Bormann, Connor Bamford, Juan L Mendoza, K Christopher Garcia, John McLauchlan, Thomas Höfer, Megan L Stanifer, Steeve Boulant
Published 2018-11-01

Interrogating the recognition landscape of a conserved HIV-specific TCR reveals distinct bacterial peptide cross-reactivity

by Juan L Mendoza, Suzanne Fischer, Marvin H Gee, Lilian H Lam, Simon Brackenridge, Fiona M Powrie, Michael Birnbaum, Andrew J McMichael, K Christopher Garcia, Geraldine M Gillespie
Published 2020-07-01

Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo

by Ricardo A Fernandes, Chaoran Li, Gang Wang, Xinbo Yang, Christina S Savvides, Caleb R Glassman, Shen Dong, Eric Luxenberg, Leah V Sibener, Michael E Birnbaum, Christophe Benoist, Diane Mathis, K Christopher Garcia
Published 2020-08-01

Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy

by Timothy F Miles, Katja Spiess, Kevin M Jude, Naotaka Tsutsumi, John S Burg, Jessica R Ingram, Deepa Waghray, Gertrud M Hjorto, Olav Larsen, Hidde L Ploegh, Mette M Rosenkilde, K Christopher Garcia
Published 2018-06-01

A polymorphic residue that attenuates the antiviral potential of interferon lambda 4 in hominid lineages.

by Connor G G Bamford, Elihu Aranday-Cortes, Ines Cordeiro Filipe, Swathi Sukumar, Daniel Mair, Ana da Silva Filipe, Juan L Mendoza, K Christopher Garcia, Shaohua Fan, Sarah A Tishkoff, John McLauchlan
Published 2018-10-01

Deconstruction of the beaten Path-Sidestep interaction network provides insights into neuromuscular system development

by Hanqing Li, Ash Watson, Agnieszka Olechwier, Michael Anaya, Siamak K Sorooshyari, Dermott P Harnett, Hyung-Kook (Peter) Lee, Jost Vielmetter, Mario A Fares, K Christopher Garcia, Engin Özkan, Juan-Pablo Labrador, Kai Zinn
Published 2017-08-01

Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments

by David Richter, Ignacio Moraga, Hauke Winkelmann, Oliver Birkholz, Stephan Wilmes, Markos Schulte, Michael Kraich, Hella Kenneweg, Oliver Beutel, Philipp Selenschik, Dirk Paterok, Martynas Gavutis, Thomas Schmidt, K. Christopher Garcia, Thomas D. Müller, Jacob Piehler
Published 2017-07-01

Selective targeting of ligand-dependent and -independent signaling by GPCR conformation-specific anti-US28 intrabodies

by Timo W. M. De Groof, Nick D. Bergkamp, Raimond Heukers, Truc Giap, Maarten P. Bebelman, Richard Goeij-de Haas, Sander R. Piersma, Connie R. Jimenez, K. Christopher Garcia, Hidde L. Ploegh, Marco Siderius, Martine J. Smit
Published 2021-07-01

Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist

by Caleb R Glassman, Leon Su, Sonia S Majri-Morrison, Hauke Winkelmann, Fei Mo, Peng Li, Magdiel Pérez-Cruz, Peggy P Ho, Ievgen Koliesnik, Nadine Nagy, Tereza Hnizdilova, Lora K Picton, Marek Kovar, Paul Bollyky, Lawrence Steinman, Everett Meyer, Jacob Piehler, Warren J Leonard, K Christopher Garcia
Published 2021-05-01

The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands

by Hugo G. Hilton, Curtis P. McMurtrey, Alex S. Han, Zakia Djaoud, Lisbeth A. Guethlein, Jeroen H. Blokhuis, Jason L. Pugh, Ana Goyos, Amir Horowitz, Rico Buchli, Ken W. Jackson, Wilfred Bardet, David A. Bushnell, Philip J. Robinson, Juan L. Mendoza, Michael E. Birnbaum, Morten Nielsen, K. Christopher Garcia, William H. Hildebrand, Peter Parham
Published 2017-05-01

Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma

by Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W. Zimmerman, Elisabeth Gurnhofer, Ivonne A. Montes-Mojarro, Brian J. Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel-Adriano Silva, K. Christopher Garcia, David Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D. Turner, A. Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Published 2021-09-01

Data publication with the structural biology data grid supports live analysis

by Peter A. Meyer, Stephanie Socias, Jason Key, Elizabeth Ransey, Emily C. Tjon, Alejandro Buschiazzo, Ming Lei, Chris Botka, James Withrow, David Neau, Kanagalaghatta Rajashankar, Karen S. Anderson, Richard H. Baxter, Stephen C. Blacklow, Titus J. Boggon, Alexandre M. J. J. Bonvin, Dominika Borek, Tom J. Brett, Amedeo Caflisch, Chung-I Chang, Walter J. Chazin, Kevin D. Corbett, Michael S. Cosgrove, Sean Crosson, Sirano Dhe-Paganon, Enrico Di Cera, Catherine L. Drennan, Michael J. Eck, Brandt F. Eichman, Qing R. Fan, Adrian R. Ferré-D'Amaré, J. Christopher Fromme, K. Christopher Garcia, Rachelle Gaudet, Peng Gong, Stephen C. Harrison, Ekaterina E. Heldwein, Zongchao Jia, Robert J. Keenan, Andrew C. Kruse, Marc Kvansakul, Jason S. McLellan, Yorgo Modis, Yunsun Nam, Zbyszek Otwinowski, Emil F. Pai, Pedro José Barbosa Pereira, Carlo Petosa, C. S. Raman, Tom A. Rapoport, Antonina Roll-Mecak, Michael K. Rosen, Gabby Rudenko, Joseph Schlessinger, Thomas U. Schwartz, Yousif Shamoo, Holger Sondermann, Yizhi J. Tao, Niraj H. Tolia, Oleg V. Tsodikov, Kenneth D. Westover, Hao Wu, Ian Foster, James S. Fraser, Filipe R. N C. Maia, Tamir Gonen, Tom Kirchhausen, Kay Diederichs, Mercè Crosas, Piotr Sliz
Published 2016-03-01