Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1

by Ajit Vikram, Young-Rae Kim, Santosh Kumar, Qiuxia Li, Modar Kassan, Julia S. Jacobs, Kaikobad Irani
Published 2016-09-01

Redox factor-1 activates endothelial SIRTUIN1 through reduction of conserved cysteine sulfhydryls in its deacetylase domain.

by Saet-Byel Jung, Cuk-Seong Kim, Young-Rae Kim, Asma Naqvi, Tohru Yamamori, Santosh Kumar, Ajay Kumar, Kaikobad Irani
Published 2013-01-01

CRIF1 deficiency induces p66shc-mediated oxidative stress and endothelial activation.

by Harsha Nagar, Saet-byel Jung, Sun Kwan Kwon, Jung-Bum Park, Minho Shong, Hee-Jung Song, Byeong Hwa Jeon, Kaikobad Irani, Cuk-Seong Kim
Published 2014-01-01

Elevated hemostasis markers after pneumonia increases one-year risk of all-cause and cardiovascular deaths.

by Sachin Yende, Gina D'Angelo, Florian Mayr, John A Kellum, Lisa Weissfeld, A Murat Kaynar, Tammy Young, Kaikobad Irani, Derek C Angus, GenIMS Investigators
Published 2011-01-01

Endothelial CaMKII as a regulator of eNOS activity and NO-mediated vasoreactivity.

by Shubha Murthy, Olha M Koval, Juan M Ramiro Diaz, Santosh Kumar, Daniel Nuno, Jason A Scott, Chantal Allamargot, Linda J Zhu, Kim Broadhurst, Velarchana Santhana, William J Kutschke, Kaikobad Irani, Kathryn G Lamping, Isabella M Grumbach
Published 2017-01-01

CR6 interacting factor 1 deficiency promotes endothelial inflammation by SIRT1 downregulation.

by Shuyu Piao, Jun Wan Lee, Harsha Nagar, Saet-Byel Jung, Sujeong Choi, Seonhee Kim, Ikjun Lee, Sung-Min Kim, Nara Shin, Yu Ran Lee, Sang Do Lee, Jin Bong Park, Kaikobad Irani, Minho Won, Gang Min Hur, Byeong Hwa Jeon, Dong Woon Kim, Cuk-Seong Kim
Published 2018-01-01