Anti-Drug Antibodies: Emerging Approaches to Predict, Reduce or Reverse Biotherapeutic Immunogenicity

by Kathleen P. Pratt
Published 2018-05-01

Editorial: Tolerating Factor VIII: Novel Strategies to Prevent and Reverse Neutralizing Anti-FVIII Antibodies

by Sébastien Lacroix-Desmazes, Kathleen P. Pratt
Published 2021-01-01

Factor VIII: Perspectives on Immunogenicity and Tolerogenic Strategies

by David W. Scott, Kathleen P. Pratt
Published 2020-01-01

Tolerating Factor VIII: Recent Progress

by Sebastien Lacroix-Desmazes, Jan Voorberg, David Lillicrap, David W. Scott, Kathleen P. Pratt
Published 2020-01-01

Predicting CD4 T-cell epitopes based on antigen cleavage, MHCII presentation, and TCR recognition.

by Dina Schneidman-Duhovny, Natalia Khuri, Guang Qiang Dong, Michael B Winter, Eric Shifrut, Nir Friedman, Charles S Craik, Kathleen P Pratt, Pedro Paz, Fred Aswad, Andrej Sali
Published 2018-01-01

Six amino acid residues in a 1200 Å2 interface mediate binding of factor VIII to an IgG4κ inhibitory antibody.

by Jasper C Lin, Ruth A Ettinger, Jason T Schuman, Ai-Hong Zhang, Muhammad Wamiq-Adhami, Phuong-Cac T Nguyen, Shelley M Nakaya-Fletcher, Komal Puranik, Arthur R Thompson, Kathleen P Pratt
Published 2015-01-01

Phenotypes of allo- and autoimmune antibody responses to FVIII characterized by surface plasmon resonance.

by Kenneth B Lewis, Richard J Hughes, Melinda S Epstein, Neil C Josephson, Christine L Kempton, Craig M Kessler, Nigel S Key, Tom E Howard, Rebecca Kruse-Jarres, Jeanne M Lusher, Christopher E Walsh, Raymond G Watts, Ruth A Ettinger, Kathleen P Pratt, PATH (Personalized Alternative Therapies for Haemophilia) Study Investigators
Published 2013-01-01

Hemophilia A Inhibitor Subjects Show Unique PBMC Gene Expression Profiles That Include Up-Regulated Innate Immune Modulators

by Ahmad Faisal Karim, Ahmad Faisal Karim, Anthony R. Soltis, Anthony R. Soltis, Anthony R. Soltis, Gauthaman Sukumar, Gauthaman Sukumar, Gauthaman Sukumar, Christoph Königs, Nadia P. Ewing, Clifton L. Dalgard, Clifton L. Dalgard, Clifton L. Dalgard, Matthew D. Wilkerson, Matthew D. Wilkerson, Matthew D. Wilkerson, Matthew D. Wilkerson, Kathleen P. Pratt
Published 2020-06-01

Prospective Assessment of SARS-CoV-2 Seroconversion (PASS) study: an observational cohort study of SARS-CoV-2 infection and vaccination in healthcare workers

by Belinda M. Jackson-Thompson, Emilie Goguet, Eric D. Laing, Cara H. Olsen, Simon Pollett, K. Monique Hollis-Perry, Santina E. Maiolatesi, Luca Illinik, Kathleen F. Ramsey, Anatalio E. Reyes, Yolanda Alcorta, Mimi A. Wong, Julian Davies, Orlando Ortega, Edward Parmelee, Alyssa R. Lindrose, Matthew Moser, Elizabeth Graydon, Andrew G. Letizia, Christopher A. Duplessis, Anuradha Ganesan, Kathleen P. Pratt, Allison M. Malloy, David W. Scott, Stephen K. Anderson, Andrew L. Snow, Clifton L. Dalgard, John H. Powers, David Tribble, Timothy H. Burgess, Christopher C. Broder, Edward Mitre
Published 2021-06-01