Development of a precision medicine pipeline to identify personalized treatments for colorectal cancer

by Erdem Altunel, Roham S. Roghani, Kai-Yuan Chen, So Young Kim, Shannon McCall, Kathryn E. Ware, Xiling Shen, Jason A. Somarelli, David S. Hsu
Published 2020-06-01

Rapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de-repression of FGFR2 and FGFR3 expression.

by Kathryn E Ware, Marianne E Marshall, Lydia R Heasley, Lindsay Marek, Trista K Hinz, Paula Hercule, Barbara A Helfrich, Robert C Doebele, Lynn E Heasley
Published 2010-11-01

An Integrative Systems Biology and Experimental Approach Identifies Convergence of Epithelial Plasticity, Metabolism, and Autophagy to Promote Chemoresistance

by Shengnan Xu, Kathryn E. Ware, Yuantong Ding, So Young Kim, Maya U. Sheth, Sneha Rao, Wesley Chan, Andrew J. Armstrong, William C. Eward, Mohit Kumar Jolly, Jason A. Somarelli
Published 2019-02-01

From the Clinic to the Bench and Back Again in One Dog Year: How a Cross-Species Pipeline to Identify New Treatments for Sarcoma Illuminates the Path Forward in Precision Medicine

by Sneha R. Rao, Jason A. Somarelli, Jason A. Somarelli, Erdem Altunel, Laura E. Selmic, Mark Byrum, Maya U. Sheth, Serene Cheng, Kathryn E. Ware, So Young Kim, Joseph A. Prinz, Nicolas Devos, David L. Corcoran, Arthur Moseley, Erik Soderblom, S. David Hsu, S. David Hsu, William C. Eward, William C. Eward
Published 2020-02-01

A Comparative Oncology Drug Discovery Pipeline to Identify and Validate New Treatments for Osteosarcoma

by Jason A. Somarelli, Gabrielle Rupprecht, Erdem Altunel, Etienne M. Flamant, Sneha Rao, Dharshan Sivaraj, Alexander L. Lazarides, Sarah M. Hoskinson, Maya U. Sheth, Serene Cheng, So Young Kim, Kathryn E. Ware, Anika Agarwal, Mark M. Cullen, Laura E. Selmic, Jeffrey I. Everitt, Shannon J. McCall, Cindy Eward, William C. Eward, David S. Hsu
Published 2020-11-01