Modelling proteins’ hidden conformations to predict antibiotic resistance

by Kathryn M. Hart, Chris M. W. Ho, Supratik Dutta, Michael L. Gross, Gregory R. Bowman
Published 2016-10-01

Thermodynamic system drift in protein evolution.

by Kathryn M Hart, Michael J Harms, Bryan H Schmidt, Carolyn Elya, Joseph W Thornton, Susan Marqusee
Published 2014-11-01

Designing small molecules to target cryptic pockets yields both positive and negative allosteric modulators.

by Kathryn M Hart, Katelyn E Moeder, Chris M W Ho, Maxwell I Zimmerman, Thomas E Frederick, Gregory R Bowman
Published 2017-01-01

Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models

by Maxwell I. Zimmerman, Kathryn M. Hart, Carrie A. Sibbald, Thomas E. Frederick, John R. Jimah, Catherine R. Knoverek, Niraj H. Tolia, Gregory R. Bowman
Published 2017-11-01