GPAT4-Generated Saturated LPAs Induce Lipotoxicity through Inhibition of Autophagy by Abnormal Formation of Omegasomes

by Yuji Shiozaki, Shinobu Miyazaki–Anzai, Kayo Okamura, Audrey L. Keenan, Masashi Masuda, Makoto Miyazaki
Published 2020-05-01

Endocytosis of albumin by podocytes elicits an inflammatory response and induces apoptotic cell death.

by Kayo Okamura, Patrick Dummer, Jeffrey Kopp, Liru Qiu, Moshe Levi, Sarah Faubel, Judith Blaine
Published 2013-01-01

Podocytes degrade endocytosed albumin primarily in lysosomes.

by John M Carson, Kayo Okamura, Hidefumi Wakashin, Kim McFann, Evgenia Dobrinskikh, Jeffrey B Kopp, Judith Blaine
Published 2014-01-01

Intratracheal IL-6 protects against lung inflammation in direct, but not indirect, causes of acute lung injury in mice.

by Rhea Bhargava, William Janssen, Christopher Altmann, Ana Andrés-Hernando, Kayo Okamura, R William Vandivier, Nilesh Ahuja, Sarah Faubel
Published 2013-01-01

Acute lung injury and acute kidney injury are established by four hours in experimental sepsis and are improved with pre, but not post, sepsis administration of TNF-α antibodies.

by Rhea Bhargava, Christopher J Altmann, Ana Andres-Hernando, Ryan G Webb, Kayo Okamura, Yimu Yang, Sandor Falk, Eric P Schmidt, Sarah Faubel
Published 2013-01-01

Three Alveolar Phenotypes Govern Lung Function in Murine Ventilator-Induced Lung Injury

by Bradford J. Smith, Bradford J. Smith, Gregory S. Roy, Alyx Cleveland, Courtney Mattson, Kayo Okamura, Chantel M. Charlebois, Katharine L. Hamlington, Michael V. Novotny, Lars Knudsen, Lars Knudsen, Matthias Ochs, R. Duncan Hite, R. Duncan Hite, Jason H. T. Bates
Published 2020-06-01