Pharmacokinetic/pharmacodynamic modeling and simulation of dotinurad, a novel uricosuric agent, in healthy volunteers

by Keisuke Motoki, Takako Igarashi, Koichi Omura, Hiroshi Nakatani, Takashi Iwanaga, Ikumi Tamai, Tetsuo Ohashi
Published 2019-12-01

Hypouricemic agents reduce indoxyl sulfate excretion by inhibiting the renal transporters OAT1/3 and ABCG2

by Tetsuya Taniguchi, Koichi Omura, Keisuke Motoki, Miku Sakai, Noriko Chikamatsu, Naoki Ashizawa, Tappei Takada, Takashi Iwanaga
Published 2021-03-01

Discovery, optimization, and evaluation of non-bile acid FXR/TGR5 dual agonists

by Sachiho Miyata, Yuji Kawashima, Miku Sakai, Masaya Matsubayashi, Keisuke Motoki, Yui Miyajima, Yousuke Watanabe, Noriko Chikamatsu, Tetsuya Taniguchi, Ryukou Tokuyama
Published 2021-04-01