Targeting Epigenetic Regulators for Endometrial Cancer Therapy: Its Molecular Biology and Potential Clinical Applications

by Futaba Inoue, Kenbun Sone, Yusuke Toyohara, Yu Takahashi, Asako Kukita, Aki Hara, Ayumi Taguchi, Michihiro Tanikawa, Tetsushi Tsuruga, Yutaka Osuga
Published 2021-02-01

The Oncogenic Polycomb Histone Methyltransferase EZH2Methylates Lysine 120 on Histone H2B and Competes Ubiquitination

by Masaharu Kogure, Masashi Takawa, Vassiliki Saloura, Kenbun Sone, Lianhua Piao, Koji Ueda, Reem Ibrahim, Tatsuhiko Tsunoda, Masanori Sugiyama, Yutaka Atomi, Yusuke Nakamura, Ryuji Hamamoto
Published 2013-11-01

A Fetus with Imperforate Anus Developing Pulmonary Hypoplasia Triggered by Transient Urethral Obstruction

by Masatake Toshimitsu, Takayuki Iriyama, Seisuke Sayama, Kan Suzuki, Satsuki Kakiuchi, Mari Ichinose, Takahiro Seyama, Kenbun Sone, Keiichi Kumasawa, Takeshi Nagamatsu, Tomoyuki Fujii, Yutaka Osuga
Published 2021-01-01

Activation of Nrf2/Keap1 pathway by oral Dimethylfumarate administration alleviates oxidative stress and age-associated infertility might be delayed in the mouse ovary

by Nana Akino, Osamu Wada-Hiraike, Wataru Isono, Hiromi Terao, Harunori Honjo, Yuichiro Miyamoto, Michihiro Tanikawa, Kenbun Sone, Mana Hirano, Miyuki Harada, Tetsuya Hirata, Yasushi Hirota, Kaori Koga, Katsutoshi Oda, Tomoyuki Fujii, Yutaka Osuga
Published 2019-02-01

Risk of endometrial cancer in patients with a preoperative diagnosis of atypical endometrial hyperplasia treated with total laparoscopic hysterectomy

by Katsutoshi Oda, Kaori Koga, Tetsuya Hirata, Masanori Maruyama, Masako Ikemura, Yoko Matsumoto, Kazunori Nagasaka, Katsuyuki Adachi, Mayuyo Mori-Uchino, Kenbun Sone, Takahide Arimoto, Osamu Wada-Hiraike, Kei Kawana, Masashi Fukayama, Tomoyuki Fujii, Yutaka Osuga
Published 2016-05-01

Epigenetic Modifier SETD8 as a Therapeutic Target for High-Grade Serous Ovarian Cancer

by Miku Wada, Asako Kukita, Kenbun Sone, Ryuji Hamamoto, Syuzo Kaneko, Masaaki Komatsu, Yu Takahashi, Futaba Inoue, Machiko Kojima, Harunori Honjoh, Ayumi Taguchi, Tomoko Kashiyama, Yuichiro Miyamoto, Michihiro Tanikawa, Tetsushi Tsuruga, Mayuyo Mori-Uchino, Osamu Wada-Hiraike, Yutaka Osuga, Tomoyuki Fujii
Published 2020-12-01

The histone methyltransferase WHSC1 is regulated by EZH2 and is important for ovarian clear cell carcinoma cell proliferation

by Machiko Kojima, Kenbun Sone, Katsutoshi Oda, Ryuji Hamamoto, Syuzo Kaneko, Shinya Oki, Asako Kukita, Hidenori Machino, Harunori Honjoh, Yoshiko Kawata, Tomoko Kashiyama, Kayo Asada, Michihiro Tanikawa, Mayuyo Mori-Uchino, Tetsushi Tsuruga, Kazunori Nagasaka, Yoko Matsumoto, Osamu Wada-Hiraike, Yutaka Osuga, Tomoyuki Fujii
Published 2019-05-01

Genotype-dependent efficacy of a dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas.

by Keiko Shoji, Katsutoshi Oda, Tomoko Kashiyama, Yuji Ikeda, Shunsuke Nakagawa, Kenbun Sone, Yuichiro Miyamoto, Haruko Hiraike, Michihiro Tanikawa, Aki Miyasaka, Takahiro Koso, Yoko Matsumoto, Osamu Wada-Hiraike, Kei Kawana, Hiroyuki Kuramoto, Frank McCormick, Hiroyuki Aburatani, Tetsu Yano, Shiro Kozuma, Yuji Taketani
Published 2012-01-01

Automated system for diagnosing endometrial cancer by adopting deep-learning technology in hysteroscopy.

by Yu Takahashi, Kenbun Sone, Katsuhiko Noda, Kaname Yoshida, Yusuke Toyohara, Kosuke Kato, Futaba Inoue, Asako Kukita, Ayumi Taguchi, Haruka Nishida, Yuichiro Miyamoto, Michihiro Tanikawa, Tetsushi Tsuruga, Takayuki Iriyama, Kazunori Nagasaka, Yoko Matsumoto, Yasushi Hirota, Osamu Hiraike-Wada, Katsutoshi Oda, Masanori Maruyama, Yutaka Osuga, Tomoyuki Fujii
Published 2021-01-01

Genome-Wide Chromatin Analysis of FFPE Tissues Using a Dual-Arm Robot with Clinical Potential

by Syuzo Kaneko, Toutai Mitsuyama, Kouya Shiraishi, Noriko Ikawa, Kanto Shozu, Ai Dozen, Hidenori Machino, Ken Asada, Masaaki Komatsu, Asako Kukita, Kenbun Sone, Hiroshi Yoshida, Noriko Motoi, Shinya Hayami, Yutaka Yoneoka, Tomoyasu Kato, Takashi Kohno, Toru Natsume, Gottfried von Keudell, Vassiliki Saloura, Hiroki Yamaue, Ryuji Hamamoto
Published 2021-04-01

Correction: Integrated Copy Number and Expression Analysis Identifies Profiles of Whole-Arm Chromosomal Alterations and Subgroups with Favorable Outcome in Ovarian Clear Cell Carci...

by Yuriko Uehara, Katsutoshi Oda, Yuji Ikeda, Takahiro Koso, Shingo Tsuji, Shogo Yamamoto, Kayo Asada, Kenbun Sone, Reiko Kurikawa, Chinami Makii, Otoe Hagiwara, Michihiro Tanikawa, Daichi Maeda, Kosei Hasegawa, Shunsuke Nakagawa, Osamu Wada-Hiraike, Kei Kawana, Masashi Fukayama, Keiichi Fujiwara, Tetsu Yano, Yutaka Osuga, Tomoyuki Fujii, Hiroyuki Aburatani
Published 2015-01-01

Integrated copy number and expression analysis identifies profiles of whole-arm chromosomal alterations and subgroups with favorable outcome in ovarian clear cell carcinomas.

by Yuriko Uehara, Katsutoshi Oda, Yuji Ikeda, Takahiro Koso, Shingo Tsuji, Shogo Yamamoto, Kayo Asada, Kenbun Sone, Reiko Kurikawa, Chinami Makii, Otoe Hagiwara, Michihiro Tanikawa, Daichi Maeda, Kosei Hasegawa, Shunsuke Nakagawa, Osamu Wada-Hiraike, Kei Kawana, Masashi Fukayama, Keiichi Fujiwara, Tetsu Yano, Yutaka Osuga, Tomoyuki Fujii, Hiroyuki Aburatani
Published 2015-01-01

Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423.

by Tomoko Kashiyama, Katsutoshi Oda, Yuji Ikeda, Yoshinobu Shiose, Yasuhide Hirota, Kanako Inaba, Chinami Makii, Reiko Kurikawa, Aki Miyasaka, Takahiro Koso, Tomohiko Fukuda, Michihiro Tanikawa, Keiko Shoji, Kenbun Sone, Takahide Arimoto, Osamu Wada-Hiraike, Kei Kawana, Shunsuke Nakagawa, Koichi Matsuda, Frank McCormick, Hiroyuki Aburatani, Tetsu Yano, Yutaka Osuga, Tomoyuki Fujii
Published 2014-01-01