Chemical Genetic Analysis of Protein Kinase Cascades

by Peter J. Alaimo, Michael A. Shogren-Knaak, Kevan M. Shokat
Published 2002-01-01

Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis.

by Tale Sliedrecht, Chao Zhang, Kevan M Shokat, Geert J P L Kops
Published 2010-04-01

Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice

by Yann Ehinger, Ziyang Zhang, Khanhky Phamluong, Drishti Soneja, Kevan M. Shokat, Dorit Ron
Published 2021-07-01

Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity

by Tingqing Guo, Patricia Marmol, Annalena Moliner, Marie Björnholm, Chao Zhang, Kevan M Shokat, Carlos F Ibanez
Published 2014-08-01

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.

by Morris E Feldman, Beth Apsel, Aino Uotila, Robbie Loewith, Zachary A Knight, Davide Ruggero, Kevan M Shokat
Published 2009-02-01

Small molecule inhibition of Csk alters affinity recognition by T cells

by Boryana N Manz, Ying Xim Tan, Adam H Courtney, Florentine Rutaganira, Ed Palmer, Kevan M Shokat, Arthur Weiss
Published 2015-08-01

In vivo conditions to identify Prkci phosphorylation targets using the analog-sensitive kinase method in zebrafish.

by Elena Cibrián Uhalte, Marieluise Kirchner, Nicole Hellwig, Jasmina J Allen, Stefan Donat, Kevan M Shokat, Matthias Selbach, Salim Abdelilah-Seyfried
Published 2012-01-01

Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

by Pedro Beltrao, Jonathan C Trinidad, Dorothea Fiedler, Assen Roguev, Wendell A Lim, Kevan M Shokat, Alma L Burlingame, Nevan J Krogan
Published 2009-06-01

Correction: Evolution of Phosphoregulation: Comparison of Phosphorylation Patterns across Yeast Species.

by Pedro Beltrao, Jonathan C. Trinidad, Dorothea Fiedler, Assen Roguev, Wendell A. Lim, Kevan M. Shokat, Alma L. Burlingame, Nevan J. Krogan
Published 2009-11-01

Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy

by Alexander A Warkentin, Michael S Lopez, Elisabeth A Lasater, Kimberly Lin, Bai-Liang He, Anskar YH Leung, Catherine C Smith, Neil P Shah, Kevan M Shokat
Published 2014-12-01

Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy.

by Olga Ksionda, Marsilius Mues, Anica M Wandler, Lisa Donker, Milou Tenhagen, Jesse Jun, Gregory S Ducker, Ksenia Matlawska-Wasowska, Kevin Shannon, Kevan M Shokat, Jeroen P Roose
Published 2018-01-01

An unbiased cell morphology-based screen for new, biologically active small molecules.

by Masahiro Tanaka, Raynard Bateman, Daniel Rauh, Eugeni Vaisberg, Shyam Ramachandani, Chao Zhang, Kirk C Hansen, Alma L Burlingame, Jay K Trautman, Kevan M Shokat, Cynthia L Adams
Published 2005-05-01

Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells.

by Lara Wohlbold, Karl A Merrick, Saurav De, Ramon Amat, Jun Hyun Kim, Stéphane Larochelle, Jasmina J Allen, Chao Zhang, Kevan M Shokat, John H J Petrini, Robert P Fisher
Published 2012-08-01

Oncogene Mimicry as a Mechanism of Primary Resistance to BRAF Inhibitors

by Martin L. Sos, Rebecca S. Levin, John D. Gordan, Juan A. Oses-Prieto, James T. Webber, Megan Salt, Byron Hann, Alma L. Burlingame, Frank McCormick, Sourav Bandyopadhyay, Kevan M. Shokat
Published 2014-08-01

Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.

by Mark E Burkard, John Maciejowski, Verónica Rodriguez-Bravo, Michael Repka, Drew M Lowery, Karl R Clauser, Chao Zhang, Kevan M Shokat, Steven A Carr, Michael B Yaffe, Prasad V Jallepalli
Published 2009-05-01

Chemical Genetics of Rapamycin-Insensitive TORC2 in S. cerevisiae

by Joseph I. Kliegman, Dorothea Fiedler, Colm J. Ryan, Yi-Fan Xu, Xiao-yang Su, David Thomas, Max C. Caccese, Ada Cheng, Michael Shales, Joshua D. Rabinowitz, Nevan J. Krogan, Kevan M. Shokat
Published 2013-12-01

Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic

by Aaron S Mendez, Jennifer Alfaro, Marisol A Morales-Soto, Arvin C Dar, Emma McCullagh, Katja Gotthardt, Han Li, Diego Acosta-Alvear, Carmela Sidrauski, Alexei V Korennykh, Sebastian Bernales, Kevan M Shokat, Peter Walter
Published 2015-05-01

A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast.

by Miriam Sansó, Karen M Lee, Laia Viladevall, Pierre-Étienne Jacques, Viviane Pagé, Stephen Nagy, Ariane Racine, Courtney V St Amour, Chao Zhang, Kevan M Shokat, Beate Schwer, François Robert, Robert P Fisher, Jason C Tanny
Published 2012-01-01

Phosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex

by Sara Hernández-Ortega, Abril Sánchez-Botet, Eva Quandt, Núria Masip, Laura Gasa, Gaetano Verde, Javier Jiménez, Rebecca S. Levin, Florentine U. Rutaganira, Alma L. Burlingame, Don Wolfgeher, Mariana P. C. Ribeiro, Stephen J. Kron, Kevan M. Shokat, Josep Clotet
Published 2019-04-01