The Essential Role Played by B Cells in Supporting Protective Immunity Against Trichuris muris Infection Is by Controlling the Th1/Th2 Balance in the Mesenteric Lymph Nodes and Dep...

by Rinal Sahputra, Dominik Ruckerl, Kevin N. Couper, Werner Muller, Kathryn J. Else
Published 2019-12-01

The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology.

by Julius Clemence R Hafalla, Carla Claser, Kevin N Couper, Georges Emile Grau, Laurent Renia, J Brian de Souza, Eleanor M Riley
Published 2012-02-01

IL-33-mediated protection against experimental cerebral malaria is linked to induction of type 2 innate lymphoid cells, M2 macrophages and regulatory T cells.

by Anne-Gaelle Besnard, Rodrigo Guabiraba, Wanda Niedbala, Jennifer Palomo, Flora Reverchon, Tovah N Shaw, Kevin N Couper, Bernhard Ryffel, Foo Y Liew
Published 2015-02-01

Parasite-derived plasma microparticles contribute significantly to malaria infection-induced inflammation through potent macrophage stimulation.

by Kevin N Couper, Tom Barnes, Julius C R Hafalla, Valery Combes, Bernhard Ryffel, Thomas Secher, Georges E Grau, Eleanor M Riley, J Brian de Souza
Published 2010-01-01

IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection.

by Kevin N Couper, Daniel G Blount, Mark S Wilson, Julius C Hafalla, Yasmine Belkaid, Masahito Kamanaka, Richard A Flavell, J Brian de Souza, Eleanor M Riley
Published 2008-02-01

WSX-1 signalling inhibits CD4⁺ T cell migration to the liver during malaria infection by repressing chemokine-independent pathways.

by Ana Villegas-Mendez, Emily Gwyer Findlay, J Brian de Souza, Lisa-Marie Grady, Christiaan J Saris, Thomas E Lane, Eleanor M Riley, Kevin N Couper
Published 2013-01-01

Infection-Induced Resistance to Experimental Cerebral Malaria Is Dependent Upon Secreted Antibody-Mediated Inhibition of Pathogenic CD8+ T Cell Responses

by Tovah N. Shaw, Tovah N. Shaw, Colette A. Inkson, Ana Villegas-Mendez, David J. Pattinson, Patrick Strangward, Kathryn J. Else, Simon J. Draper, Leo A. H. Zeef, Kevin N. Couper
Published 2019-02-01

The plasma membrane calcium ATPase 4 does not influence parasite levels but partially promotes experimental cerebral malaria during murine blood stage malaria

by Ana Villegas-Mendez, Nicholas Stafford, Michael J. Haley, Normalita Eka Pravitasari, Florence Baudoin, Adnan Ali, Puji Budi Setia Asih, Josephine E. Siregar, Esther Baena, Din Syafruddin, Kevin N. Couper, Delvac Oceandy
Published 2021-07-01

IL-27 receptor signalling restricts the formation of pathogenic, terminally differentiated Th1 cells during malaria infection by repressing IL-12 dependent signals.

by Ana Villegas-Mendez, J Brian de Souza, Seen-Wai Lavelle, Emily Gwyer Findlay, Tovah N Shaw, Nico van Rooijen, Christiaan J Saris, Christopher A Hunter, Eleanor M Riley, Kevin N Couper
Published 2013-01-01

Comparison of CD8+ T Cell Accumulation in the Brain During Human and Murine Cerebral Malaria

by Valentina Barrera, Michael J. Haley, Patrick Strangward, Elizabeth Attree, Steve Kamiza, Karl B. Seydel, Karl B. Seydel, Terrie E. Taylor, Terrie E. Taylor, Danny A. Milner, Alister G. Craig, Kevin N. Couper
Published 2019-07-01

A quantitative brain map of experimental cerebral malaria pathology.

by Patrick Strangward, Michael J Haley, Tovah N Shaw, Jean-Marc Schwartz, Rachel Greig, Aleksandr Mironov, J Brian de Souza, Sheena M Cruickshank, Alister G Craig, Danny A Milner, Stuart M Allan, Kevin N Couper
Published 2017-03-01

Perivascular Arrest of CD8+ T Cells Is a Signature of Experimental Cerebral Malaria.

by Tovah N Shaw, Phillip J Stewart-Hutchinson, Patrick Strangward, Durga B Dandamudi, Jonathan A Coles, Ana Villegas-Mendez, Julio Gallego-Delgado, Nico van Rooijen, Egor Zindy, Ana Rodriguez, James M Brewer, Kevin N Couper, Michael L Dustin
Published 2015-01-01