Degradation and Transmission of Tau by Autophagic-Endolysosomal Networks and Potential Therapeutic Targets for Tauopathy

by Shanya Jiang, Kiran Bhaskar
Published 2020-10-01

Optical induction of autophagy via Transcription factor EB (TFEB) reduces pathological tau in neurons.

by Jessica L Binder, Praveen Chander, Vojo Deretic, Jason P Weick, Kiran Bhaskar
Published 2020-01-01

Interleukin-10 deficiency exacerbates inflammation-induced tau pathology

by Lea L. Weston, Shanya Jiang, Devon Chisholm, Lauren L. Jantzie, Kiran Bhaskar
Published 2021-07-01

Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events

by Kiran Bhaskar, Nicole Maphis, Guixiang Xu, Nicholas H. Varvel, Olga N. Kokiko-Cochran, Jason P. Weick, Susan M. Staugaitis, Astrid Cardona, Richard M. Ransohoff, Karl Herrup, Bruce T. Lamb
Published 2014-02-01

Hypoxia promotes tau hyperphosphorylation with associated neuropathology in vascular dysfunction

by Limor Raz, Kiran Bhaskar, John Weaver, Sandro Marini, Quanguang Zhang, Jeffery F. Thompson, Candice Espinoza, Sulaiman Iqbal, Nicole M. Maphis, Lea Weston, Laurel O. Sillerud, Arvind Caprihan, John C. Pesko, Erik B. Erhardt, Gary A. Rosenberg
Published 2019-06-01

Genetically enhancing the expression of chemokine domain of CX3CL1 fails to prevent tau pathology in mouse models of tauopathy

by Shane M. Bemiller, Nicole M. Maphis, Shane V. Formica, Gina N. Wilson, Crystal M. Miller, Guixiang Xu, Olga N. Kokiko-Cochran, Ki-Wook Kim, Steffen Jung, Judy L. Cannon, Samuel D. Crish, Astrid E. Cardona, Bruce T. Lamb, Kiran Bhaskar
Published 2018-09-01

Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway

by Shanya Jiang, Nicole M. Maphis, Jessica Binder, Devon Chisholm, Lea Weston, Walter Duran, Crina Peterson, Amber Zimmerman, Michael A. Mandell, Stephen D. Jett, Eileen Bigio, Changiz Geula, Nikolaos Mellios, Jason P. Weick, Gary A. Rosenberg, Eicke Latz, Michael T. Heneka, Kiran Bhaskar
Published 2021-09-01