Spectrophores as one-dimensional descriptors calculated from three-dimensional atomic properties: applications ranging from scaffold hopping to multi-target virtual screening

by Rafaela Gladysz, Fabio Mendes Dos Santos, Wilfried Langenaeker, Gert Thijs, Koen Augustyns, Hans De Winter
Published 2018-03-01

Identification and Characterization of Approved Drugs and Drug-Like Compounds as Covalent <i>Escherichia coli</i> ClpP Inhibitors

by Elisa Sassetti, Cristina Durante Cruz, Päivi Tammela, Mathias Winterhalter, Koen Augustyns, Philip Gribbon, Björn Windshügel
Published 2019-05-01

Asymmetric synthesis of γ-chloro-α,β-diamino- and β,γ-aziridino-α-aminoacylpyrrolidines and -piperidines via stereoselective Mannich-type additions of N-(diphenylmethylene)glycinam...

by Gert Callebaut, Sven Mangelinckx, Pieter Van der Veken, Karl W. Törnroos, Koen Augustyns, Norbert De Kimpe
Published 2012-12-01

An essential signal peptide peptidase identified in an RNAi screen of serine peptidases of Trypanosoma brucei.

by Catherine X Moss, Elaine Brown, Alana Hamilton, Pieter Van der Veken, Koen Augustyns, Jeremy C Mottram
Published 2015-01-01

ClpP Protease, a Promising Antimicrobial Target

by Carlos Moreno-Cinos, Kenneth Goossens, Irene G. Salado, Pieter Van Der Veken, Hans De Winter, Koen Augustyns
Published 2019-05-01

The effect of pharmacological inhibition of Serine Proteases on neuronal networks in vitro

by Sebastiaan Van De Vijver, Stephan Missault, Jeroen Van Soom, Pieter Van Der Veken, Koen Augustyns, Jurgen Joossens, Stefanie Dedeurwaerdere, Michele Giugliano
Published 2019-04-01

Selective Activity-Based Probes Targeting Fibroblast Activation Protein (FAP)

by Johannes Vrijdag, Anvesh Jallapally, An De Decker, Koen Janssen, Filipe Elvas, Steven Staelens, Ingrid De Meester, Koen Augustyns, Anne-Marie Lambeir, Pieter Van der Veken
Published 2019-08-01

In Vitro and In Situ Activity-Based Labeling of Fibroblast Activation Protein with UAMC1110-Derived Probes

by Yentl Van Rymenant, Muhammet Tanc, Roos Van Elzen, An Bracke, Olivier De Wever, Koen Augustyns, Anne-Marie Lambeir, Mark Kockx, Ingrid De Meester, Pieter Van Der Veken
Published 2021-04-01

The Effect of a Novel Serine Protease Inhibitor on Inflammation and Intestinal Permeability in a Murine Colitis Transfer Model

by Hanne Van Spaendonk, Hanne Van Spaendonk, Hannah Ceuleers, Hannah Ceuleers, Annemieke Smet, Annemieke Smet, Maya Berg, Jurgen Joossens, Pieter Van der Veken, Pieter Van der Veken, Sven M. Francque, Sven M. Francque, Sven M. Francque, Anne-Marie Lambeir, Anne-Marie Lambeir, Joris G. De Man, Joris G. De Man, Ingrid De Meester, Ingrid De Meester, Koen Augustyns, Koen Augustyns, Benedicte Y. De Winter, Benedicte Y. De Winter, Benedicte Y. De Winter
Published 2021-06-01

Local Colonic Administration of a Serine Protease Inhibitor Improves Post-Inflammatory Visceral Hypersensitivity in Rats

by Nikita Hanning, Michelle De bruyn, Hannah Ceuleers, Tim Boogaerts, Maya Berg, Annemieke Smet, Heiko U. De Schepper, Jurgen Joossens, Alexander L. N. van Nuijs, Joris G. De Man, Koen Augustyns, Ingrid De Meester, Benedicte Y. De Winter
Published 2021-05-01

Selective Glucocorticoid Receptor Properties of GSK866 Analogs with Cysteine Reactive Warheads

by Chandra S. Chirumamilla, Ajay Palagani, Balu Kamaraj, Ken Declerck, Marinus W. C. Verbeek, Ryabtsova Oksana, Karolien De Bosscher, Nadia Bougarne, Bart Ruttens, Kris Gevaert, René Houtman, Winnok H. De Vos, Jurgen Joossens, Pieter Van Der Veken, Koen Augustyns, Xaveer Van Ostade, Annemie Bogaerts, Hans De Winter, Wim Vanden Berghe
Published 2017-11-01

Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity

by Sanaa S. Botros, Samia William, Abdel-Nasser A. Sabra, Naglaa M. El-Lakkany, Sayed H. Seif el-Din, Alfonso García-Rubia, Victor Sebastián-Pérez, Antoni R. Blaazer, Erik de Heuvel, Maarten Sijm, Yang Zheng, Irene G. Salado, Jane C. Munday, Louis Maes, Iwan J.P. de Esch, Geert J. Sterk, Koen Augustyns, Rob Leurs, Carmen Gil, Harry P. De Koning
Published 2019-04-01