Phenotypic analysis of a transgenic Drosophila model of Alzheimer’s amyloid-β toxicity

by Michiko Sekiya, Koichi M. Iijima
Published 2021-06-01

Knockdown of wfs1, a fly homolog of Wolfram syndrome 1, in the nervous system increases susceptibility to age- and stress-induced neuronal dysfunction and degeneration in Drosophil...

by Yasufumi Sakakibara, Michiko Sekiya, Naoki Fujisaki, Xiuming Quan, Koichi M Iijima
Published 2018-01-01

Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer’s disease

by Yasufumi Sakakibara, Michiko Sekiya, Takashi Saito, Takaomi C. Saido, Koichi M. Iijima
Published 2019-03-01

Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis

by Yasufumi Sakakibara, Michiko Sekiya, Takashi Saito, Takaomi C. Saido, Koichi M. Iijima
Published 2018-07-01

Increasing neuronal glucose uptake attenuates brain aging and promotes life span under dietary restriction in Drosophila

by Mikiko Oka, Emiko Suzuki, Akiko Asada, Taro Saito, Koichi M. Iijima, Kanae Ando
Published 2021-01-01

Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity...

by Kanae Ando, Akiko Maruko-Otake, Yosuke Ohtake, Motoki Hayashishita, Michiko Sekiya, Koichi M Iijima
Published 2016-03-01

Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1.

by Kanae Iijima-Ando, Michiko Sekiya, Akiko Maruko-Otake, Yosuke Ohtake, Emiko Suzuki, Bingwei Lu, Koichi M Iijima
Published 2012-01-01

Integrated biology approach reveals molecular and pathological interactions among Alzheimer’s Aβ42, Tau, TREM2, and TYROBP in Drosophila models

by Michiko Sekiya, Minghui Wang, Naoki Fujisaki, Yasufumi Sakakibara, Xiuming Quan, Michelle E. Ehrlich, Philip L. De Jager, David A. Bennett, Eric E. Schadt, Sam Gandy, Kanae Ando, Bin Zhang, Koichi M. Iijima
Published 2018-03-01