Prediction Model of Aryl Hydrocarbon Receptor Activation by a Novel QSAR Approach, DeepSnap–Deep Learning

by Yasunari Matsuzaka, Takuomi Hosaka, Anna Ogaito, Kouichi Yoshinari, Yoshihiro Uesawa
Published 2020-03-01

Effect of health foods on cytochrome P450-mediated drug metabolism

by Takamitsu Sasaki, Yu Sato, Takeshi Kumagai, Kouichi Yoshinari, Kiyoshi Nagata
Published 2017-05-01

PXR Functionally Interacts with NF-κB and AP-1 to Downregulate the Inflammation-Induced Expression of Chemokine CXCL2 in Mice

by Maya Okamura, Ryota Shizu, Taiki Abe, Susumu Kodama, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
Published 2020-10-01

Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pre...

by Ryota Shizu, Satoshi Benoki, Yuki Numakura, Susumu Kodama, Masaaki Miyata, Yasushi Yamazoe, Kouichi Yoshinari
Published 2013-01-01

Identification of average molecular weight (AMW) as a useful chemical descriptor to discriminate liver injury-inducing drugs.

by Yuki Shimizu, Takamitsu Sasaki, Jun-Ichi Takeshita, Michiko Watanabe, Ryota Shizu, Takuomi Hosaka, Kouichi Yoshinari
Published 2021-01-01

Activation of PXR, CAR and PPARα by pyrethroid pesticides and the effect of metabolism by rat liver microsomes

by Chieri Fujino, Yoko Watanabe, Seigo Sanoh, Hiroyuki Nakajima, Naoto Uramaru, Hiroyuki Kojima, Kouichi Yoshinari, Shigeru Ohta, Shigeyuki Kitamura
Published 2019-09-01