Novel mechanism of increasing cerebral vascular constriction in acute hyperglycemia and diabetes through adenylyl cyclase 5‐generated cyclic adenosine monophosphate

by Kenichi Sakamoto, Koutaro Yokote
Published 2020-07-01

Human glomerular transcriptome of diabetic kidneys: Can the podocyte cytoskeleton be a therapeutic target?

by Yoshiro Maezawa, Koutaro Yokote
Published 2019-03-01

Sodium-Glucose Cotransporter 2 Inhibitors Improve Chronic Diabetic Macular Edema

by Yoko Takatsuna, Ryoichi Ishibashi, Tomoaki Tatsumi, Masaya Koshizaka, Takayuki Baba, Shuichi Yamamoto, Koutaro Yokote
Published 2020-01-01

Palladium and platinum nanoparticles attenuate aging-like skin atrophy via antioxidant activity in mice.

by Shuichi Shibuya, Yusuke Ozawa, Kenji Watanabe, Naotaka Izuo, Toshihiko Toda, Koutaro Yokote, Takahiko Shimizu
Published 2014-01-01

Sod1 Loss Induces Intrinsic Superoxide Accumulation Leading to p53-Mediated Growth Arrest and Apoptosis

by Kenji Watanabe, Shuichi Shibuya, Hirofumi Koyama, Yusuke Ozawa, Toshihiko Toda, Koutaro Yokote, Takahiko Shimizu
Published 2013-05-01

Superoxide Dismutase 1 Loss Disturbs Intracellular Redox Signaling, Resulting in Global Age-Related Pathological Changes

by Kenji Watanabe, Shuichi Shibuya, Yusuke Ozawa, Hidetoshi Nojiri, Naotaka Izuo, Koutaro Yokote, Takahiko Shimizu
Published 2014-01-01

Effects of pemafibrate on glucose metabolism markers and liver function tests in patients with hypertriglyceridemia: a pooled analysis of six phase 2 and phase 3 randomized double‐...

by Koutaro Yokote, Shizuya Yamashita, Hidenori Arai, Eiichi Araki, Mitsunori Matsushita, Toshiaki Nojima, Hideki Suganami, Shun Ishibashi
Published 2021-05-01

Efficacy and Safety of Pemafibrate, a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα): Pooled Analysis of Phase 2 and 3 Studies in Dyslipidemic Pat...

by Shizuya Yamashita, Hidenori Arai, Koutaro Yokote, Eiichi Araki, Mitsunori Matsushita, Toshiaki Nojima, Hideki Suganami, Shun Ishibashi
Published 2019-11-01

N-3 polyunsaturated fatty acids improve lipoprotein particle size and concentration in Japanese patients with type 2 diabetes and hypertriglyceridemia: a pilot study

by Kana Ide, Masaya Koshizaka, Hirotake Tokuyama, Takahiko Tokuyama, Takahiro Ishikawa, Yoshiro Maezawa, Minoru Takemoto, Koutaro Yokote
Published 2018-03-01

Long-Term Efficacy and Safety of Pemafibrate, a Novel Selective Peroxisome Proliferator-Activated Receptor-α Modulator (SPPARMα), in Dyslipidemic Patients with Renal Impairment

by Koutaro Yokote, Shizuya Yamashita, Hidenori Arai, Eiichi Araki, Hideki Suganami, Shun Ishibashi, on Behalf of the K-877 Study Group
Published 2019-02-01

Central administration of sodium-glucose cotransporter-2 inhibitors increases food intake involving adenosine monophosphate-activated protein kinase phosphorylation in the lateral...

by Kenji Takeda, Hiraku Ono, Ko Ishikawa, Tomohiro Ohno, Jin Kumagai, Hidetoshi Ochiai, Ai Matumoto, Hidetaka Yokoh, Koutaro Yokote
Published 2021-08-01

Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells

by Mulki Angela, Yusuke Endo, Hikari K. Asou, Takeshi Yamamoto, Damon J. Tumes, Hirotake Tokuyama, Koutaro Yokote, Toshinori Nakayama
Published 2016-11-01

Multidrug use positively correlates with high-risk prescriptions in the Japanese elderly: a longitudinal study

by Sayaka Arai, Takahiro Ishikawa, Hisaya Kato, Masaya Koshizaka, Yoshio Maezawa, Takako Nakamura, Takaaki Suzuki, Koutaro Yokote, Itsuko Ishii
Published 2019-09-01

Obesity Drives Th17 Cell Differentiation by Inducing the Lipid Metabolic Kinase, ACC1

by Yusuke Endo, Hikari K. Asou, Nao Matsugae, Kiyoshi Hirahara, Kenta Shinoda, Damon J. Tumes, Hirotake Tokuyama, Koutaro Yokote, Toshinori Nakayama
Published 2015-08-01

Apple procyanidins promote mitochondrial biogenesis and proteoglycan biosynthesis in chondrocytes

by Isao Masuda, Masato Koike, Shohei Nakashima, Yu Mizutani, Yusuke Ozawa, Kenji Watanabe, Yoko Sawada, Hiroshi Sugiyama, Atsushi Sugimoto, Hidetoshi Nojiri, Koichi Sashihara, Koutaro Yokote, Takahiko Shimizu
Published 2018-05-01

Pituitary Adenylate Cyclase-Activating Polypeptide Protects Glomerular Podocytes from Inflammatory Injuries

by Kenichi Sakamoto, Kyoko Kuno, Minoru Takemoto, Peng He, Takahiro Ishikawa, Shunichiro Onishi, Ryoichi Ishibashi, Emiko Okabe, Mayumi Shoji, Akiko Hattori, Masaya Yamaga, Kazuki Kobayashi, Harukiyo Kawamura, Hirotake Tokuyama, Yoshiro Maezawa, Koutaro Yokote
Published 2015-01-01

Detection of MYD88 L265P mutation by next-generation deep sequencing in peripheral blood mononuclear cells of Waldenström's macroglobulinemia and IgM monoclonal gammopathy of undet...

by Ayako Nakamura, Chikako Ohwada, Masahiro Takeuchi, Yusuke Takeda, Shokichi Tsukamoto, Naoya Mimura, Oshima-Hasegawa Nagisa, Yasumasa Sugita, Hiroaki Tanaka, Hisashi Wakita, Nobuyuki Aotsuka, Kosei Matsue, Koutaro Yokote, Osamu Ohara, Chiaki Nakaseko, Emiko Sakaida
Published 2019-01-01

Generation of disease-specific and CRISPR/Cas9-mediated gene-corrected iPS cells from a patient with adult progeria Werner syndrome

by Hisaya Kato, Yoshiro Maezawa, Yasuo Ouchi, Naoya Takayama, Masamitsu Sone, Kanako Sone, Aki Takada-Watanabe, Kyoko Tsujimura, Masaya Koshizaka, Sayaka Nagasawa, Hisako Saitoh, Manami Ohtaka, Mahito Nakanishi, Hidetoshi Tahara, Akira Shimamoto, Atsushi Iwama, Koji Eto, Koutaro Yokote
Published 2021-05-01

Multihormonal pituitary adenoma concomitant with Pit-1 and Tpit lineage cells causing acromegaly associated with subclinical Cushing’s disease: a case report

by Tomoko Takiguchi, Hisashi Koide, Hidekazu Nagano, Akitoshi Nakayama, Masanori Fujimoto, Ai Tamura, Eri Komai, Akina Shiga, Takashi Kono, Seiichiro Higuchi, Ikki Sakuma, Naoko Hashimoto, Sawako Suzuki, Yui Miyabayashi, Norio Ishiwatari, Kentaro Horiguchi, Yukio Nakatani, Koutaro Yokote, Tomoaki Tanaka
Published 2017-09-01

Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture.

by Akira Shimamoto, Harunobu Kagawa, Kazumasa Zensho, Yukihiro Sera, Yasuhiro Kazuki, Mitsuhiko Osaki, Mitsuo Oshimura, Yasuhito Ishigaki, Kanya Hamasaki, Yoshiaki Kodama, Shinsuke Yuasa, Keiichi Fukuda, Kyotaro Hirashima, Hiroyuki Seimiya, Hirofumi Koyama, Takahiko Shimizu, Minoru Takemoto, Koutaro Yokote, Makoto Goto, Hidetoshi Tahara
Published 2014-01-01