CD8+ regulatory T cells, and not CD4+ T cells, dominate suppressive phenotype and function after in vitro live Mycobacterium bovis-BCG activation of human cells.

by Mardi C Boer, Krista E van Meijgaarden, Simone A Joosten, Tom H M Ottenhoff
Published 2014-01-01

Human CD8+ T-cells recognizing peptides from Mycobacterium tuberculosis (Mtb) presented by HLA-E have an unorthodox Th2-like, multifunctional, Mtb inhibitory phenotype and represen...

by Krista E van Meijgaarden, Mariëlle C Haks, Nadia Caccamo, Francesco Dieli, Tom H M Ottenhoff, Simone A Joosten
Published 2015-03-01

INNOVATIVE STRATEGIES TO IDENTIFY M. TUBERCULOSIS ANTIGENS AND EPITOPES USING GENOME-WIDE ANALYSES

by Annemieke eGeluk, Krista E van Meijgaarden, Simone A Joosten, Susanna eCommandeur, Susanna eCommandeur, Tom H.M. Ottenhoff
Published 2014-06-01

Patients with Tuberculosis Have a Dysfunctional Circulating B-Cell Compartment, Which Normalizes following Successful Treatment.

by Simone A Joosten, Krista E van Meijgaarden, Franca Del Nonno, Andrea Baiocchini, Linda Petrone, Valentina Vanini, Hermelijn H Smits, Fabrizio Palmieri, Delia Goletti, Tom H M Ottenhoff
Published 2016-06-01

A novel view on the pathogenesis of complications after intravesical BCG for bladder cancer

by Manu P. Bilsen, Krista E. van Meijgaarden, Hanna K. de Jong, Simone A. Joosten, Corine Prins, Lucia J.M. Kroft, Jacqueline T. Jonker, Stijn Crobach, Rob C. Pelger, Tom H.M. Ottenhoff, Sandra M. Arend
Published 2018-07-01

Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity.

by Simone A Joosten, Krista E van Meijgaarden, Pascale C van Weeren, Fatima Kazi, Annemieke Geluk, Nigel D L Savage, Jan W Drijfhout, Darren R Flower, Willem A Hanekom, Michèl R Klein, Tom H M Ottenhoff
Published 2010-02-01

Disparate Tuberculosis Disease Development in Macaque Species Is Associated With Innate Immunity

by Karin Dijkman, Richard A. W. Vervenne, Claudia C. Sombroek, Charelle Boot, Sam O. Hofman, Krista E. van Meijgaarden, Tom H. M. Ottenhoff, Clemens H. M. Kocken, Krista G. Haanstra, Michel P. M. Vierboom, Frank A. W. Verreck
Published 2019-11-01

Cross-laboratory evaluation of multiplex bead assays including independent common reference standards for immunological monitoring of observational and interventional human studies...

by Krista E van Meijgaarden, Bhagwati Khatri, Steven G Smith, Anne M F H Drittij, Roelof A de Paus, Jelle J Goeman, Mei M Ho, Hazel M Dockrell, Helen McShane, Simone A Joosten, Tom H M Ottenhoff
Published 2018-01-01

Intracellular Cytokine Staining and Flow Cytometry: Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines.

by Steven G Smith, Kaatje Smits, Simone A Joosten, Krista E van Meijgaarden, Iman Satti, Helen A Fletcher, Nadia Caccamo, Francesco Dieli, Francoise Mascart, Helen McShane, Hazel M Dockrell, Tom H M Ottenhoff, TBVI TB Biomarker Working Group
Published 2015-01-01

Clonal analysis of the T-cell response to in vivo expressed Mycobacterium tuberculosis protein Rv2034, using a CD154 expression based T-cell cloning method.

by Susanna Commandeur, Mariateresa Coppola, Karin Dijkman, Annemieke H Friggen, Krista E van Meijgaarden, Susan J F van den Eeden, Louis Wilson, Jolien J van der Ploeg-van Schip, Kees L M C Franken, Annemieke Geluk, Tom H M Ottenhoff
Published 2014-01-01

T-cell regulation in lepromatous leprosy.

by Kidist Bobosha, Louis Wilson, Krista E van Meijgaarden, Yonas Bekele, Martha Zewdie, Jolien J van der Ploeg-van Schip, Markos Abebe, Jemal Hussein, Saraswoti Khadge, Kapil D Neupane, Deanna A Hagge, Ekaterina S Jordanova, Abraham Aseffa, Tom H M Ottenhoff, Annemieke Geluk
Published 2014-04-01

Cell-Mediated Immune Responses to in vivo-Expressed and Stage-Specific Mycobacterium tuberculosis Antigens in Latent and Active Tuberculosis Across Different Age Groups

by Mariateresa Coppola, Raquel Villar-Hernández, Krista E. van Meijgaarden, Irene Latorre, Beatriz Muriel Moreno, Esther Garcia-Garcia, Kees L. M. C. Franken, Cristina Prat, Zoran Stojanovic, Maria Luiza De Souza Galvão, Joan-Pau Millet, Josefina Sabriá, Adrián Sánchez-Montalva, Adrián Sánchez-Montalva, Antoni Noguera-Julian, Annemieke Geluk, Jose Domínguez, Tom H. M. Ottenhoff
Published 2020-02-01