Mithramycin, an Agent for Developing New Therapeutic Drugs for Neurodegenerative Diseases

by Nobuhiro Osada, Yasuhiro Kosuge, Kumiko Ishige, Yoshihisa Ito
Published 2013-01-01

Expression of Microsomal Prostaglandin E Synthase-1 in the Spinal Cord in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

by Hiroko Miyagishi, Yasuhiro Kosuge, Kumiko Ishige, Yoshihisa Ito
Published 2012-01-01

Activation of Dopamine D4 Receptors Is Protective Against Hypoxia/ Reoxygenation-Induced Cell Death in HT22 Cells

by Saori Shimada, Mioko Hirabayashi, Kumiko Ishige, Yasuhiro Kosuge, Tetsuro Kihara, Yoshihisa Ito
Published 2010-01-01

Bidens pilosa Extract Administered after Symptom Onset Attenuates Glial Activation, Improves Motor Performance, and Prolongs Survival in a Mouse Model of Amyotrophic Lateral Sclero...

by Yasuhiro Kosuge, Erina Kaneko, Hiroshi Nango, Hiroko Miyagishi, Kumiko Ishige, Yoshihisa Ito
Published 2020-01-01

Prostaglandin E2 facilitates neurite outgrowth in a motor neuron-like cell line, NSC-34

by Hiroshi Nango, Yasuhiro Kosuge, Hiroko Miyagishi, Kosuke Sugawa, Yoshihisa Ito, Kumiko Ishige
Published 2017-10-01

Highly Efficient Conversion of Motor Neuron-Like NSC-34 Cells into Functional Motor Neurons by Prostaglandin E₂

by Hiroshi Nango, Yasuhiro Kosuge, Masaki Sato, Yoshiyuki Shibukawa, Yuri Aono, Tadashi Saigusa, Yoshihisa Ito, Kumiko Ishige
Published 2020-07-01

The Molecular Mechanisms Underlying Prostaglandin D₂-Induced Neuritogenesis in Motor Neuron-Like NSC-34 Cells

by Hiroshi Nango, Yasuhiro Kosuge, Nana Yoshimura, Hiroko Miyagishi, Takanori Kanazawa, Kaname Hashizaki, Toyofumi Suzuki, Kumiko Ishige
Published 2020-04-01

Generation of Cellular Reactive Oxygen Species by Activation of the EP2 Receptor Contributes to Prostaglandin E2-Induced Cytotoxicity in Motor Neuron-Like NSC-34 Cells

by Yasuhiro Kosuge, Hiroshi Nango, Hiroki Kasai, Takuya Yanagi, Takayuki Mawatari, Kenta Nishiyama, Hiroko Miyagishi, Kumiko Ishige, Yoshihisa Ito
Published 2020-01-01

Prostaglandin E2-Induced Cell Death is Mediated by Activation of EP2 Receptors in Motor Neuron-like NSC-34 Cells

by Hiroko Miyagishi, Yasuhiro Kosuge, Yuki Yoneoka, Maiko Ozone, Manami Endo, Nobuhiro Osada, Kumiko Ishige, Kuniko Kusama-Eguchi, Yoshihisa Ito
Published 2013-01-01

Deletion of Bmal1 Prevents Diet-Induced Ectopic Fat Accumulation by Controlling Oxidative Capacity in the Skeletal Muscle

by Taira Wada, Yuya Ichihashi, Emi Suzuki, Yasuhiro Kosuge, Kumiko Ishige, Taketo Uchiyama, Makoto Makishima, Reiko Nakao, Katsutaka Oishi, Shigeki Shimba
Published 2018-09-01

Apelin deficiency accelerates the progression of amyotrophic lateral sclerosis.

by Atsushi Kasai, Toshihiko Kinjo, Rie Ishihara, Ikumi Sakai, Yuki Ishimaru, Yasuhiro Yoshioka, Akiko Yamamuro, Kumiko Ishige, Yoshihisa Ito, Sadaaki Maeda
Published 2011-01-01

Neuroprotective effect of S-allyl-l-cysteine derivatives against endoplasmic reticulum stress-induced cytotoxicity is independent of calpain inhibition

by Toru Imai, Yasuhiro Kosuge, Hiroaki Saito, Taketo Uchiyama, Taira Wada, Shigeki Shimba, Kumiko Ishige, Shinichi Miyairi, Makoto Makishima, Yoshihisa Ito
Published 2016-03-01

Role of Caspase-12 in Amyloid β-Peptide-Induced Toxicity in Organotypic Hippocampal Slices Cultured for Long Periods

by Kumiko Ishige, Noritaka Takagi, Toru Imai, Wolf Dieter Rausch, Yasuhiro Kosuge, Tetsuroh Kihara, Kuniko Kusama-Eguchi, Hiroko Ikeda, Alexander Rudolf Cools, John Lionel Waddington, Noriaki Koshikawa, Yoshihisa Ito
Published 2007-01-01

Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation.

by Shigeki Shimba, Tomohiro Ogawa, Shunsuke Hitosugi, Yuya Ichihashi, Yuki Nakadaira, Munehiro Kobayashi, Masakatsu Tezuka, Yasuhiro Kosuge, Kumiko Ishige, Yoshihisa Ito, Kazuo Komiyama, Yuko Okamatsu-Ogura, Kazuhiro Kimura, Masayuki Saito
Published 2011-01-01