Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha.

by Lavinia Nardinocchi, Rosa Puca, Ada Sacchi, Gideon Rechavi, David Givol, Gabriella D'Orazi
Published 2009-08-01

Homeodomain interacting protein kinase 2: a target for Alzheimer's beta amyloid leading to misfolded p53 and inappropriate cell survival.

by Cristina Lanni, Lavinia Nardinocchi, Rosa Puca, Serena Stanga, Daniela Uberti, Maurizio Memo, Stefano Govoni, Gabriella D'Orazi, Marco Racchi
Published 2010-04-01

Zinc downregulates HIF-1α and inhibits its activity in tumor cells in vitro and in vivo.

by Lavinia Nardinocchi, Valentina Pantisano, Rosa Puca, Manuela Porru, Aurora Aiello, Annalisa Grasselli, Carlo Leonetti, Michal Safran, Gideon Rechavi, David Givol, Antonella Farsetti, Gabriella D'Orazi
Published 2010-12-01