Reduced telomere length is associated with fibrotic joint disease suggesting that impaired telomere repair contributes to joint fibrosis.

by Nicholas S Kalson, Tim M Brock, Massimo Mangino, Stella M Fabiane, Derek A Mann, Lee A Borthwick, David J Deehan, Frances M K Williams
Published 2018-01-01

Is CFTR-delF508 really absent from the apical membrane of the airway epithelium?

by Lee A Borthwick, Phil Botha, Bernard Verdon, Malcolm J Brodlie, Aaron Gardner, David Bourn, Gail E Johnson, Mike A Gray, Andrew J Fisher
Published 2011-01-01

Role of Interaction and Nucleoside Diphosphate Kinase B in Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Function by cAMP-Dependent Protein Kinase A.

by Lee A Borthwick, Mathieu Kerbiriou, Christopher J Taylor, Giorgio Cozza, Ioan Lascu, Edith H Postel, Diane Cassidy, Pascal Trouvé, Anil Mehta, Louise Robson, Richmond Muimo
Published 2016-01-01

Role of arginase 1 from myeloid cells in th2-dominated lung inflammation.

by Luke Barron, Amber M Smith, Karim C El Kasmi, Joseph E Qualls, Xiaozhu Huang, Allen Cheever, Lee A Borthwick, Mark S Wilson, Peter J Murray, Thomas A Wynn
Published 2013-01-01

Incomplete deletion of IL-4Rα by LysM(Cre) reveals distinct subsets of M2 macrophages controlling inflammation and fibrosis in chronic schistosomiasis.

by Kevin M Vannella, Luke Barron, Lee A Borthwick, Kristen N Kindrachuk, Prakash Babu Narasimhan, Kevin M Hart, Robert W Thompson, Sandra White, Allen W Cheever, Thirumalai R Ramalingam, Thomas A Wynn
Published 2014-09-01

Pellino-1 Regulates the Responses of the Airway to Viral Infection

by Elizabeth K. Marsh, Elizabeth K. Marsh, Elizabeth C. Prestwich, Lynne Williams, Amber R. Hart, Clare F. Muir, Lisa C. Parker, Marnix R. Jonker, Irene H. Heijink, Wim Timens, Mark Fife, Tracy Hussell, Marc B. Hershenson, J. Kelley Bentley, Shao-Cong Sun, Ben S. Barksby, Lee A. Borthwick, James P. Stewart, Ian Sabroe, David H. Dockrell, David H. Dockrell, Helen M. Marriott
Published 2020-08-01

Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis

by Alison E. John, Rebecca H. Graves, K. Tao Pun, Giovanni Vitulli, Ellen J. Forty, Paul F. Mercer, Josie L. Morrell, John W. Barrett, Rebecca F. Rogers, Maryam Hafeji, Lloyd I. Bibby, Elaine Gower, Valerie S. Morrison, Yim Man, James A. Roper, Jeni C. Luckett, Lee A. Borthwick, Ben S. Barksby, Rachel A. Burgoyne, Rory Barnes, Joelle Le, David J. Flint, Susan Pyne, Anthony Habgood, Louise A. Organ, Chitra Joseph, Rochelle C. Edwards-Pritchard, Toby M. Maher, Andrew J. Fisher, Natasja Stæhr Gudmann, Diana J. Leeming, Rachel C. Chambers, Pauline T. Lukey, Richard P. Marshall, Simon J. F. Macdonald, R. Gisli Jenkins, Robert J. Slack
Published 2020-09-01