Targeting of GFP-Cre to the mouse Cyp11a1 locus both drives cre recombinase expression in steroidogenic cells and permits generation of Cyp11a1 knock out mice.

by Laura O'Hara, Jean Philippe York, Pumin Zhang, Lee B Smith
Published 2014-01-01

Specific Transcriptomic Signatures and Dual Regulation of Steroidogenesis Between Fetal and Adult Mouse Leydig Cells

by Pauline Sararols, Isabelle Stévant, Yasmine Neirijnck, Diane Rebourcet, Annalucia Darbey, Michael K. Curley, Françoise Kühne, Emmanouil Dermitzakis, Emmanouil Dermitzakis, Lee B. Smith, Lee B. Smith, Serge Nef
Published 2021-06-01

Modelling steroidogenesis: a framework model to support hypothesis generation and testing across endocrine studies

by Laura O’Hara, Peter J. O’Shaughnessy, Tom C. Freeman, Lee B. Smith
Published 2018-04-01

Pituitary androgen receptor signalling regulates prolactin but not gonadotrophins in the male mouse.

by Laura O'Hara, Michael Curley, Maria Tedim Ferreira, Lyndsey Cruickshanks, Laura Milne, Lee B Smith
Published 2015-01-01

Influence of Androgen Receptor in Vascular Cells on Reperfusion following Hindlimb Ischaemia.

by Junxi Wu, Patrick W F Hadoke, Kaloyan Takov, Agnieszka Korczak, Martin A Denvir, Lee B Smith
Published 2016-01-01

Exogenous Gonadotrophin Stimulation Induces Partial Maturation of Human Sertoli Cells in a Testicular Xenotransplantation Model for Fertility Preservation

by Marsida Hutka, Lee B. Smith, Ellen Goossens, W. Hamish B. Wallace, Jan-Bernd Stukenborg, Rod T. Mitchell
Published 2020-01-01

LKB1 is an essential regulator of spermatozoa release during spermiation in the mammalian testis.

by Fiona C Denison, Lee B Smith, Phillip J Muckett, Laura O'Hara, David Carling, Angela Woods
Published 2011-01-01

Androgen Receptor Is Dispensable for X-Zone Regression in the Female Adrenal but Regulates Post-Partum Corticosterone Levels and Protects Cortex Integrity

by Anne-Louise Gannon, Anne-Louise Gannon, Laura O’Hara, Laura O’Hara, Ian J. Mason, Anne Jørgensen, Anne Jørgensen, Hanne Frederiksen, Hanne Frederiksen, Michael Curley, Laura Milne, Sarah Smith, Rod T. Mitchell, Lee B. Smith, Lee B. Smith
Published 2021-01-01

Deciphering Cell Lineage Specification during Male Sex Determination with Single-Cell RNA Sequencing

by Isabelle Stévant, Yasmine Neirijnck, Christelle Borel, Jessica Escoffier, Lee B. Smith, Stylianos E. Antonarakis, Emmanouil T. Dermitzakis, Serge Nef
Published 2018-02-01

Relationship of transcriptional markers to Leydig cell number in the mouse testis.

by Diane Rebourcet, Ana Monteiro, Lyndsey Cruickshanks, Nathan Jeffery, Sarah Smith, Laura Milne, Peter J O'Shaughnessy, Lee B Smith
Published 2019-01-01

Androgen action via testicular arteriole smooth muscle cells is important for Leydig cell function, vasomotion and testicular fluid dynamics.

by Michelle Welsh, Richard M Sharpe, Lindsey Moffat, Nina Atanassova, Philippa T K Saunders, Sigrid Kilter, Anders Bergh, Lee B Smith
Published 2010-10-01

Germ cell-specific targeting of DICER or DGCR8 reveals a novel role for endo-siRNAs in the progression of mammalian spermatogenesis and male fertility.

by Céline Zimmermann, Yannick Romero, Maria Warnefors, Adem Bilican, Christelle Borel, Lee B Smith, Noora Kotaja, Henrik Kaessmann, Serge Nef
Published 2014-01-01

Acute versus chronic loss of mammalian Azi1/Cep131 results in distinct ciliary phenotypes.

by Emma A Hall, Margaret Keighren, Matthew J Ford, Tracey Davey, Andrew P Jarman, Lee B Smith, Ian J Jackson, Pleasantine Mill
Published 2013-01-01

Sertoli cells maintain Leydig cell number and peritubular myoid cell activity in the adult mouse testis.

by Diane Rebourcet, Peter J O'Shaughnessy, Ana Monteiro, Laura Milne, Lyndsey Cruickshanks, Nathan Jeffrey, Florian Guillou, Tom C Freeman, Rod T Mitchell, Lee B Smith
Published 2014-01-01

Androgen receptor expression is required to ensure development of adult Leydig cells and to prevent development of steroidogenic cells with adrenal characteristics in the mouse tes...

by Peter J. O’Shaughnessy, Rod T. Mitchell, Ana Monteiro, Laura O’Hara, Lyndsey Cruickshanks, Hedi Claahsen-van der Grinten, Pamela Brown, Margaret Abel, Lee B. Smith
Published 2019-04-01

Fertility Preservation in Childhood Cancer: Endocrine Activity in Prepubertal Human Testis Xenografts Exposed to a Pubertal Hormone Environment

by Marsida Hutka, Prashant Kadam, Dorien Van Saen, Natalie Z. M. Homer, Jaime Onofre, W. Hamish B. Wallace, Lee B. Smith, Jan-Bernd Stukenborg, Ellen Goossens, Rod T. Mitchell
Published 2020-09-01

Low-dose tamoxifen treatment in juvenile males has long-term adverse effects on the reproductive system: implications for inducible transgenics

by Saloni H. Patel, Laura O’Hara, Nina Atanassova, Sarah E. Smith, Michael K. Curley, Diane Rebourcet, Annalucia L. Darbey, Anne-Louise Gannon, Richard M. Sharpe, Lee B. Smith
Published 2017-08-01

Diethylstilboestrol exposure does not reduce testosterone production in human fetal testis xenografts.

by Rod T Mitchell, Richard M Sharpe, Richard A Anderson, Chris McKinnell, Sheila Macpherson, Lee B Smith, W Hamish B Wallace, Christopher J H Kelnar, Sander van den Driesche
Published 2013-01-01

Modelling the Structure and Dynamics of Biological Pathways.

by Laura O'Hara, Alessandra Livigni, Thanos Theo, Benjamin Boyer, Tim Angus, Derek Wright, Sz-Hau Chen, Sobia Raza, Mark W Barnett, Paul Digard, Lee B Smith, Tom C Freeman
Published 2016-08-01

Proposed role for COUP-TFII in regulating fetal Leydig cell steroidogenesis, perturbation of which leads to masculinization disorders in rodents.

by Sander van den Driesche, Marion Walker, Chris McKinnell, Hayley M Scott, Sharon L Eddie, Rod T Mitchell, Jonathan R Seckl, Amanda J Drake, Lee B Smith, Richard A Anderson, Richard M Sharpe
Published 2012-01-01