Soluble immune complexes shift the TLR-induced cytokine production of distinct polarized human macrophage subsets towards IL-10.

by Carmen A Ambarus, Kim C M Santegoets, Lenny van Bon, Mark H Wenink, Paul P Tak, Timothy R D J Radstake, Dominique L P Baeten
Published 2012-01-01

The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes.

by Timothy R D J Radstake, Lenny van Bon, Jasper Broen, Anila Hussiani, Roger Hesselstrand, Dirk M Wuttge, Yanhui Deng, Robbert Simms, Erik Lubberts, Robert Lafyatis
Published 2009-06-01

Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression.

by Timothy R D J Radstake, Lenny van Bon, Jasper Broen, Mark Wenink, Kim Santegoets, Yanhui Deng, Anila Hussaini, Robert Simms, William W Cruikshank, Robert Lafyatis
Published 2009-06-01

Implication of miR-126 and miR-139-5p in Plasmacytoid Dendritic Cell Dysregulation in Systemic Sclerosis

by Eleni Chouri, Maojie Wang, Maarten R. Hillen, Chiara Angiolilli, Sandra C. Silva-Cardoso, Catharina G.K. Wichers, Maarten van der Kroef, Cornelis P.J. Bekker, Marta Cossu, Lenny van Bon, Alsya J. Affandi, Tiago Carvalheiro, Aridaman Pandit, Joel A.G. van Roon, Lorenzo Beretta, Boudewijn M. T. Burgering, Timothy R.D.J. Radstake, Marzia Rossato
Published 2021-01-01