T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources

by Sarah Bonte, Stijn De Munter, Glenn Goetgeluk, Joline Ingels, Melissa Pille, Lore Billiet, Tom Taghon, Georges Leclercq, Bart Vandekerckhove, Tessa Kerre
Published 2020-01-01

In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced...

by Sarah Bonte, Stijn de Munter, Lore Billiet, Glenn Goetgeluk, Joline Ingels, Hanne Jansen, Melissa Pille, Laurenz de Cock, Karin Weening, Tom Taghon, Georges Leclercq, Bart Vandekerckhove, Tessa Kerre
Published 2021-01-01

Human Thymic CD10⁺ PD-1⁺ Intraepithelial Lymphocyte Precursors Acquire Interleukin-15 Responsiveness at the CD1a^– CD95⁺ CD28^–...

by Lore Billiet, Glenn Goetgeluk, Sarah Bonte, Stijn De Munter, Laurenz De Cock, Melissa Pille, Joline Ingels, Hanne Jansen, Karin Weening, Filip Van Nieuwerburgh, Tessa Kerre, Tom Taghon, Georges Leclercq, Bart Vandekerckhove
Published 2020-11-01

Rapid and Effective Generation of Nanobody Based CARs using PCR and Gibson Assembly

by Stijn De Munter, Alexander Van Parys, Layla Bral, Joline Ingels, Glenn Goetgeluk, Sarah Bonte, Melissa Pille, Lore Billiet, Karin Weening, Annick Verhee, Jose Van der Heyden, Tom Taghon, Georges Leclercq, Tessa Kerre, Jan Tavernier, Bart Vandekerckhove
Published 2020-01-01