Generation and initial characterization of FDD knock in mice.

by Luca Giliberto, Shuji Matsuda, Ruben Vidal, Luciano D'Adamio, Luciano D'Adamio
Published 2009-11-01

APP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesic...

by Dolores Del Prete, Franco Lombino, Xinran Liu, Luciano D'Adamio, Luciano D'Adamio
Published 2014-01-01

An intracellular threonine of amyloid-β precursor protein mediates synaptic plasticity deficits and memory loss.

by Franco Lombino, Fabrizio Biundo, Robert Tamayev, Ottavio Arancio, Luciano D'Adamio, Luciano D'Adamio
Published 2013-01-01

The intracellular threonine of amyloid precursor protein that is essential for docking of Pin1 is dispensable for developmental function.

by Alessia P M Barbagallo, Zilai Wang, Hui Zheng, Luciano D'Adamio, Luciano D'Adamio
Published 2011-03-01

Transgenic expression of the amyloid-beta precursor protein-intracellular domain does not induce Alzheimer's Disease-like traits in vivo.

by Luca Giliberto, Cristina d'Abramo, Christopher Michael Acker, Peter Davies, Luciano D'Adamio, Luciano D'Adamio
Published 2010-07-01

Significance of Blood and Cerebrospinal Fluid Biomarkers for Alzheimer’s Disease: Sensitivity, Specificity and Potential for Clinical Use

by Cristina d’Abramo, Luciano D’Adamio, Luca Giliberto
Published 2020-09-01

Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo.

by Alessia P M Barbagallo, Richard Weldon, Robert Tamayev, Dawang Zhou, Luca Giliberto, Oded Foreman, Luciano D'Adamio, Luciano D'Adamio
Published 2010-11-01

Opposite changes in APP processing and human Aβ levels in rats carrying either a protective or a pathogenic APP mutation

by Marc D Tambini, Kelly A Norris, Luciano D'Adamio
Published 2020-02-01

Proteomic Characterization of a Mouse Model of Familial Danish Dementia

by Monica Vitale, Giovanni Renzone, Shuji Matsuda, Andrea Scaloni, Luciano D'Adamio, Nicola Zambrano
Published 2012-01-01

APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses

by Tomas Fanutza, Dolores Del Prete, Michael J Ford, Pablo E Castillo, Luciano D’Adamio
Published 2015-11-01

Microglia TREM2R47H Alzheimer-linked variant enhances excitatory transmission and reduces LTP via increased TNF-α levels

by Siqiang Ren, Wen Yao, Marc D Tambini, Tao Yin, Kelly A Norris, Luciano D'Adamio
Published 2020-06-01

Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade

by Erica Acquarone, Elentina K. Argyrousi, Manon van den Berg, Walter Gulisano, Mauro Fà, Agnieszka Staniszewski, Elisa Calcagno, Elisa Zuccarello, Luciano D’Adamio, Shi-Xian Deng, Daniela Puzzo, Ottavio Arancio, Jole Fiorito
Published 2019-06-01

LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent

by Daniela Puzzo, Roberto Piacentini, Mauro Fá, Walter Gulisano, Domenica D Li Puma, Agnes Staniszewski, Hong Zhang, Maria Rosaria Tropea, Sara Cocco, Agostino Palmeri, Paul Fraser, Luciano D'Adamio, Claudio Grassi, Ottavio Arancio
Published 2017-07-01