An experimental verification of the predicted effects of promoter TATA-box polymorphisms associated with human diseases on interactions between the TATA boxes and TATA-binding prot...

by Ludmila Savinkova, Irina Drachkova, Tatyana Arshinova, Petr Ponomarenko, Mikhail Ponomarenko, Nikolay Kolchanov
Published 2013-01-01

How to Use SNP_TATA_Comparator to Find a Significant Change in Gene Expression Caused by the Regulatory SNP of This Gene’s Promoter via a Change in Affinity of the TATA-Binding Pro...

by Mikhail Ponomarenko, Dmitry Rasskazov, Olga Arkova, Petr Ponomarenko, Valentin Suslov, Ludmila Savinkova, Nikolay Kolchanov
Published 2015-01-01

Unannotated single nucleotide polymorphisms in the TATA box of erythropoiesis genes show in vitro positive involvements in cognitive and mental disorders

by Mikhail Ponomarenko, Ekaterina Sharypova, Irina Drachkova, Irina Chadaeva, Olga Arkova, Olga Podkolodnaya, Petr Ponomarenko, Nikolay Kolchanov, Ludmila Savinkova
Published 2020-10-01

Candidate SNP Markers of Atherogenesis Significantly Shifting the Affinity of TATA-Binding Protein for Human Gene Promoters Show Stabilizing Natural Selection as a Sum of Neutral D...

by Mikhail Ponomarenko, Dmitry Rasskazov, Irina Chadaeva, Ekaterina Sharypova, Irina Drachkova, Dmitry Oshchepkov, Petr Ponomarenko, Ludmila Savinkova, Evgeniya Oshchepkova, Maria Nazarenko, Nikolay Kolchanov
Published 2020-02-01

Candidate SNP Markers of Chronopathologies Are Predicted by a Significant Change in the Affinity of TATA-Binding Protein for Human Gene Promoters

by Petr Ponomarenko, Dmitry Rasskazov, Valentin Suslov, Ekaterina Sharypova, Ludmila Savinkova, Olga Podkolodnaya, Nikolay L. Podkolodny, Natalya N. Tverdokhleb, Irina Chadaeva, Mikhail Ponomarenko, Nikolay Kolchanov
Published 2016-01-01

Domestication Explains Two-Thirds of Differential-Gene-Expression Variance between Domestic and Wild Animals; The Remaining One-Third Reflects Intraspecific and Interspecific Varia...

by Irina Chadaeva, Petr Ponomarenko, Rimma Kozhemyakina, Valentin Suslov, Anton Bogomolov, Natalya Klimova, Svetlana Shikhevich, Ludmila Savinkova, Dmitry Oshchepkov, Nikolay A. Kolchanov, Arcady Markel, Mikhail Ponomarenko
Published 2021-09-01

A Bioinformatics Model of Human Diseases on the Basis of Differentially Expressed Genes (of Domestic versus Wild Animals) That Are Orthologs of Human Genes Associated with Reproduc...

by Gennady Vasiliev, Irina Chadaeva, Dmitry Rasskazov, Petr Ponomarenko, Ekaterina Sharypova, Irina Drachkova, Anton Bogomolov, Ludmila Savinkova, Mikhail Ponomarenko, Nikolay Kolchanov, Alexander Osadchuk, Dmitry Oshchepkov, Ludmila Osadchuk
Published 2021-02-01

Disruptive Selection of Human Immunostimulatory and Immunosuppressive Genes Both Provokes and Prevents Rheumatoid Arthritis, Respectively, as a Self-Domestication Syndrome

by Natalya V. Klimova, Evgeniya Oshchepkova, Irina Chadaeva, Ekaterina Sharypova, Petr Ponomarenko, Irina Drachkova, Dmitry Rasskazov, Dmitry Oshchepkov, Mikhail Ponomarenko, Mikhail Ponomarenko, Ludmila Savinkova, Nikolay A. Kolchanov, Vladimir Kozlov
Published 2021-06-01

Natural Selection Equally Supports the Human Tendencies in Subordination and Domination: A Genome-Wide Study With in silico Confirmation and in vivo Validation in Mice

by Irina Chadaeva, Irina Chadaeva, Petr Ponomarenko, Dmitry Rasskazov, Ekaterina Sharypova, Elena Kashina, Maxim Kleshchev, Mikhail Ponomarenko, Mikhail Ponomarenko, Vladimir Naumenko, Ludmila Savinkova, Nikolay Kolchanov, Nikolay Kolchanov, Ludmila Osadchuk, Alexandr Osadchuk
Published 2019-02-01

Disruptive natural selection by male reproductive potential prevents underexpression of protein-coding genes on the human Y chromosome as a self-domestication syndrome

by Mikhail Ponomarenko, Maxim Kleshchev, Petr Ponomarenko, Irina Chadaeva, Ekaterina Sharypova, Dmitry Rasskazov, Semyon Kolmykov, Irina Drachkova, Gennady Vasiliev, Natalia Gutorova, Elena Ignatieva, Ludmila Savinkova, Anton Bogomolov, Ludmila Osadchuk, Alexandr Osadchuk, Dmitry Oshchepkov
Published 2020-10-01