PKIS deep dive yields a chemical starting point for dark kinases and a cell active BRSK2 inhibitor

by Tigist Y. Tamir, David H. Drewry, Carrow Wells, M. Ben Major, Alison D. Axtman
Published 2020-09-01

PPP6C Negatively Regulates STING-Dependent Innate Immune Responses

by Guoxin Ni, Zhe Ma, Jason P. Wong, Zhigang Zhang, Emily Cousins, M. Ben Major, Blossom Damania
Published 2020-08-01

TRIM67 regulates exocytic mode and neuronal morphogenesis via SNAP47

by Fabio L. Urbina, Shalini Menon, Dennis Goldfarb, Reginald Edwards, M. Ben Major, Patrick Brennwald, Stephanie L. Gupton
Published 2021-02-01

Correlation of alterations in the KEAP1/CUL3/NFE2L2 pathway with radiation failure in larynx squamous cell carcinoma

by Siddharth Sheth, Douglas R. Farquhar, Travis P. Schrank, Wesley Stepp, Angela Mazul, Michele Hayward, Nicholas Lenze, Paul Little, Heejoon Jo, M. Ben Major, Bhishamjit S. Chera, Jose P. Zevallos, D. Neil Hayes
Published 2021-08-01

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.

by Jennifer L Franks, Raquel C Martinez-Chacin, Xianxi Wang, Rochelle L Tiedemann, Thomas Bonacci, Rajarshi Choudhury, Derek L Bolhuis, Taylor P Enrico, Ryan D Mouery, Jeffrey S Damrauer, Feng Yan, Joseph S Harrison, M Ben Major, Katherine A Hoadley, Aussie Suzuki, Scott B Rothbart, Nicholas G Brown, Michael J Emanuele
Published 2020-12-01

Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell

by Maritza Puray-Chavez, Kyle M. LaPak, Travis P. Schrank, Jennifer L. Elliott, Dhaval P. Bhatt, Megan J. Agajanian, Ria Jasuja, Dana Q. Lawson, Keanu Davis, Paul W. Rothlauf, Zhuoming Liu, Heejoon Jo, Nakyung Lee, Kasyap Tenneti, Jenna E. Eschbach, Christian Shema Mugisha, Emily M. Cousins, Erica W. Cloer, Hung R. Vuong, Laura A. VanBlargan, Adam L. Bailey, Pavlo Gilchuk, James E. Crowe, Jr., Michael S. Diamond, D. Neil Hayes, Sean P.J. Whelan, Amjad Horani, Steven L. Brody, Dennis Goldfarb, M. Ben Major, Sebla B. Kutluay
Published 2021-07-01