Blood transcriptomic biomarkers for tuberculosis screening: time to redefine our target populations?

by Rishi Kumar Gupta, Mahdad Noursadeghi
Published 2021-06-01

DC priming by M. vaccae inhibits Th2 responses in contrast to specific TLR2 priming and is associated with selective activation of the CREB pathway.

by Nina Le Bert, Benjamin M Chain, Graham Rook, Mahdad Noursadeghi
Published 2011-04-01

Paradoxical reactions and immune reconstitution inflammatory syndrome in tuberculosis

by Lucy C.K. Bell, Ronan Breen, Robert F. Miller, Mahdad Noursadeghi, Marc Lipman
Published 2015-03-01

Cohort study protocol: Bioresource in Adult Infectious Diseases (BioAID) [version 1; referees: 2 approved]

by Laura J. Shallcross, Alexander Mentzer, Saadia Rahman, Graham S. Cooke, Shiranee Sriskandan, Mahdad Noursadeghi
Published 2018-08-01

Tumor Necrosis Factor (TNF) Bioactivity at the Site of an Acute Cell-Mediated Immune Response Is Preserved in Rheumatoid Arthritis Patients Responding to Anti-TNF Therapy

by Rachel Byng-Maddick, Rachel Byng-Maddick, Carolin T. Turner, Gabriele Pollara, Matthew Ellis, Naomi J. Guppy, Lucy C. K. Bell, Michael R. Ehrenstein, Michael R. Ehrenstein, Mahdad Noursadeghi, Mahdad Noursadeghi
Published 2017-08-01

Exploring a combined biomarker for tuberculosis treatment response: protocol for a prospective observational cohort study

by Heinke Kunst, Timothy D McHugh, Simon Tiberi, Mahdad Noursadeghi, Hanif Esmail, Vanessa Hack, Julian Surey
Published 2021-07-01

Viral infection triggers interferon-induced expulsion of live Cryptococcus neoformans by macrophages.

by Paula I Seoane, Leanne M Taylor-Smith, David Stirling, Lucy C K Bell, Mahdad Noursadeghi, Dalan Bailey, Robin C May
Published 2020-02-01

Adherent human alveolar macrophages exhibit a transient pro-inflammatory profile that confounds responses to innate immune stimulation.

by Gillian S Tomlinson, Helen Booth, Sarah J Petit, Elspeth Potton, Greg J Towers, Robert F Miller, Benjamin M Chain, Mahdad Noursadeghi
Published 2012-01-01

Cerebrospinal fluid cytokine profiles predict risk of early mortality and immune reconstitution inflammatory syndrome in HIV-associated cryptococcal meningitis.

by Joseph N Jarvis, Graeme Meintjes, Tihana Bicanic, Viviana Buffa, Louise Hogan, Stephanie Mo, Gillian Tomlinson, Pascale Kropf, Mahdad Noursadeghi, Thomas S Harrison
Published 2015-04-01

Validation of Immune Cell Modules in Multicellular Transcriptomic Data.

by Gabriele Pollara, Matthew J Murray, James M Heather, Rachel Byng-Maddick, Naomi Guppy, Matthew Ellis, Carolin T Turner, Benjamin M Chain, Mahdad Noursadeghi
Published 2017-01-01

Transcriptional response modules characterize IL-1β and IL-6 activity in COVID-19

by Lucy C.K. Bell, Cem Meydan, Jacob Kim, Jonathan Foox, Daniel Butler, Christopher E. Mason, Sagi D. Shapira, Mahdad Noursadeghi, Gabriele Pollara
Published 2021-01-01

Microinvasion by Streptococcus pneumoniae induces epithelial innate immunity during colonisation at the human mucosal surface

by Caroline M. Weight, Cristina Venturini, Sherin Pojar, Simon P. Jochems, Jesús Reiné, Elissavet Nikolaou, Carla Solórzano, Mahdad Noursadeghi, Jeremy S. Brown, Daniela M. Ferreira, Robert S. Heyderman
Published 2019-07-01

Relative Contributions of Extracellular and Internalized Bacteria to Early Macrophage Proinflammatory Responses to Streptococcus pneumoniae

by Jimstan Periselneris, Giuseppe Ercoli, Tracey Pollard, Suneeta Chimalapati, Emilie Camberlein, Gabriella Szylar, Catherine Hyams, Gillian Tomlinson, Fernanda C. Petersen, R. Andres Floto, Mahdad Noursadeghi, Jeremy S. Brown
Published 2019-09-01

A Linear Epitope in the N-Terminal Domain of CCR5 and Its Interaction with Antibody.

by Benny Chain, Jack Arnold, Samia Akthar, Michael Brandt, David Davis, Mahdad Noursadeghi, Thabo Lapp, Changhua Ji, Surya Sankuratri, Yanjing Zhang, Lata Govada, Emmanuel Saridakis, Naomi Chayen
Published 2015-01-01

Assessing the Impact of Sample Heterogeneity on Transcriptome Analysis of Human Diseases Using MDP Webtool

by André N. A. Gonçalves, Melissa Lever, Pedro S. T. Russo, Bruno Gomes-Correia, Alysson H. Urbanski, Gabriele Pollara, Mahdad Noursadeghi, Vinicius Maracaja-Coutinho, Helder I. Nakaya, Helder I. Nakaya
Published 2019-10-01

Clinical academic research in the time of Corona: A simulation study in England and a call for action.

by Amitava Banerjee, Michail Katsoulis, Alvina G Lai, Laura Pasea, Thomas A Treibel, Charlotte Manisty, Spiros Denaxas, Giovanni Quarta, Harry Hemingway, João L Cavalcante, Mahdad Noursadeghi, James C Moon
Published 2020-01-01

In Vivo Molecular Dissection of the Effects of HIV-1 in Active Tuberculosis.

by Lucy C K Bell, Gabriele Pollara, Mellissa Pascoe, Gillian S Tomlinson, Rannakoe J Lehloenya, Jennifer Roe, Richard Meldau, Robert F Miller, Alan Ramsay, Benjamin M Chain, Keertan Dheda, Mahdad Noursadeghi
Published 2016-03-01

Persistent T Cell Repertoire Perturbation and T Cell Activation in HIV After Long Term Treatment

by Carolin T. Turner, James Brown, James Brown, Emily Shaw, Imran Uddin, Evdokia Tsaliki, Jennifer K. Roe, Gabriele Pollara, Yuxin Sun, James M. Heather, Marc Lipman, Marc Lipman, Benny Chain, Mahdad Noursadeghi
Published 2021-02-01

Quantitative Characterization of the T Cell Receptor Repertoire of Naïve and Memory Subsets Using an Integrated Experimental and Computational Pipeline Which Is Robust, Economical,...

by Theres Oakes, James M. Heather, Katharine Best, Rachel Byng-Maddick, Connor Husovsky, Mazlina Ismail, Kroopa Joshi, Gavin Maxwell, Mahdad Noursadeghi, Natalie Riddell, Tabea Ruehl, Carolin T. Turner, Imran Uddin, Benny Chain
Published 2017-10-01

Blood transcriptomic discrimination of bacterial and viral infections in the emergency department: a multi-cohort observational validation study

by Dayle Sampson, Thomas D. Yager, Brian Fox, Laura Shallcross, Leo McHugh, Therese Seldon, Antony Rapisarda, Richard B. Brandon, Krupa Navalkar, Nandi Simpson, Sian Stafford, Eliza Gil, Cristina Venturini, Evi Tsaliki, Jennifer Roe, Benjamin Chain, Mahdad Noursadeghi
Published 2020-07-01