4',6 diamidino 2 phenylindole Animals Article Disease Models, Animal Drosophila Lung Neoplasms Mice Mutation Oncogenes Raf protein afatinib alcohol animal animal experiment animal model antineoplastic activity cancer prognosis cancer size controlled study dimethyl sulfoxide disease model ectopic expression epidermal growth factor receptor fluindostatin gene expression gene overexpression genetics glycerol high throughput screening human