Alpha-Synuclein and Lipids: The Elephant in the Room?

by Alessia Sarchione, Antoine Marchand, Jean-Marc Taymans, Marie-Christine Chartier-Harlin
Published 2021-09-01

Mind the Gap: LRRK2 Phenotypes in the Clinic vs. in Patient Cells

by Liesel Goveas, Eugénie Mutez, Marie-Christine Chartier-Harlin, Jean-Marc Taymans
Published 2021-04-01

LRRK2 Phosphorylation, More Than an Epiphenomenon

by Antoine Marchand, Antoine Marchand, Matthieu Drouyer, Matthieu Drouyer, Alessia Sarchione, Alessia Sarchione, Marie-Christine Chartier-Harlin, Marie-Christine Chartier-Harlin, Jean-Marc Taymans, Jean-Marc Taymans
Published 2020-06-01

NADPH oxidases in Parkinson’s disease: a systematic review

by Karim Belarbi, Elodie Cuvelier, Alain Destée, Bernard Gressier, Marie-Christine Chartier-Harlin
Published 2017-11-01

The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson’s Disease

by Hardy J. Rideout, Marie-Christine Chartier-Harlin, Marie-Christine Chartier-Harlin, Matthew J. Fell, Warren D. Hirst, Sarah Huntwork-Rodriguez, Cheryl E. G. Leyns, Omar S. Mabrouk, Jean-Marc Taymans, Jean-Marc Taymans
Published 2020-08-01

Glycosphingolipids and neuroinflammation in Parkinson’s disease

by Karim Belarbi, Elodie Cuvelier, Marie-Amandine Bonte, Mazarine Desplanque, Bernard Gressier, David Devos, Marie-Christine Chartier-Harlin
Published 2020-10-01

Trends in Glucocerebrosides Research: A Systematic Review

by Mazarine Desplanque, Mazarine Desplanque, Marie-Amandine Bonte, Bernard Gressier, Bernard Gressier, David Devos, David Devos, Marie-Christine Chartier-Harlin, Karim Belarbi, Karim Belarbi
Published 2020-10-01

PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2

by Laura Civiero, Susanna Cogo, Susanna Cogo, Anneleen Kiekens, Claudia Morganti, Isabella Tessari, Evy Lobbestael, Veerle Baekelandt, Jean-Marc Taymans, Jean-Marc Taymans, Marie-Christine Chartier-Harlin, Marie-Christine Chartier-Harlin, Cinzia Franchin, Cinzia Franchin, Giorgio Arrigoni, Giorgio Arrigoni, Patrick A. Lewis, Giovanni Piccoli, Luigi Bubacco, Mark R. Cookson, Paolo Pinton, Elisa Greggio
Published 2017-12-01

Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes

by Kushal Sejwal, Mohamed Chami, Hervé Rémigy, Renée Vancraenenbroeck, William Sibran, Rosmarie Sütterlin, Paul Baumgartner, Robert McLeod, Marie-Christine Chartier-Harlin, Veerle Baekelandt, Henning Stahlberg, Jean-Marc Taymans
Published 2017-08-01

RNA-binding disturbances as a continuum from spinocerebellar ataxia type 2 to Parkinson disease

by Aurore Nkiliza, Eugénie Mutez, Clémence Simonin, Frédéric Leprêtre, Aurélie Duflot, Martin Figeac, Céline Villenet, Pierre Semaille, Thomas Comptdaer, Alexandre Genet, Bernard Sablonnière, David Devos, Luc Defebvre, Alain Destée, Marie-Christine Chartier-Harlin
Published 2016-12-01

Involvement of the immune system, endocytosis and EIF2 signaling in both genetically determined and sporadic forms of Parkinson's disease

by Eugénie Mutez, Aurore Nkiliza, Karim Belarbi, Amélie de Broucker, Christel Vanbesien-Mailliot, Séverine Bleuse, Aurélie Duflot, Thomas Comptdaer, Pierre Semaille, Renaud Blervaque, David Hot, Frederic Leprêtre, Martin Figeac, Alain Destée, Marie-Christine Chartier-Harlin
Published 2014-03-01

Overexpression of Wild-Type Human Alpha-Synuclein Causes Metabolism Abnormalities in Thy1-aSYN Transgenic Mice

by Elodie Cuvelier, Mathieu Méquinion, Coline Leghay, William Sibran, Aliçia Stievenard, Alessia Sarchione, Marie-Amandine Bonte, Christel Vanbesien-Mailliot, Odile Viltart, Kevin Saitoski, Emilie Caron, Alexandra Labarthe, Thomas Comptdaer, Pierre Semaille, Hélène Carrié, Eugénie Mutez, Bernard Gressier, Alain Destée, Marie-Christine Chartier-Harlin, Karim Belarbi
Published 2018-10-01

Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation

by Matthieu Drouyer, Marc F. Bolliger, Evy Lobbestael, Chris Van den Haute, Marco Emanuele, Réginald Lefebvre, William Sibran, Tina De Wit, Coline Leghay, Eugénie Mutez, Nicolas Dzamko, Glenda M. Halliday, Shigeo Murayama, Alain Martoriati, Katia Cailliau, Jean-François Bodart, Marie-Christine Chartier-Harlin, Veerle Baekelandt, R. Jeremy Nichols, Jean-Marc Taymans
Published 2021-09-01

The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo

by Noémie Cresto, Camille Gardier, Marie-Claude Gaillard, Francesco Gubinelli, Pauline Roost, Daniela Molina, Charlène Josephine, Noëlle Dufour, Gwenaëlle Auregan, Martine Guillermier, Suéva Bernier, Caroline Jan, Pauline Gipchtein, Philippe Hantraye, Marie-Christine Chartier-Harlin, Gilles Bonvento, Nadja Van Camp, Jean-Marc Taymans, Karine Cambon, Géraldine Liot, Alexis-Pierre Bemelmans, Emmanuel Brouillet
Published 2021-06-01

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation

by Jesús Madero-Pérez, Elena Fdez, Belén Fernández, Antonio J. Lara Ordóñez, Marian Blanca Ramírez, Patricia Gómez-Suaga, Dieter Waschbüsch, Evy Lobbestael, Veerle Baekelandt, Angus C. Nairn, Javier Ruiz-Martínez, Ana Aiastui, Adolfo López de Munain, Pawel Lis, Thomas Comptdaer, Jean-Marc Taymans, Marie-Christine Chartier-Harlin, Alexandria Beilina, Adriano Gonnelli, Mark R. Cookson, Elisa Greggio, Sabine Hilfiker
Published 2018-01-01