Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Brain Levels of Drug in Rat

by Bárbara Sánchez-Dengra, Isabel Gonzalez-Alvarez, Marival Bermejo, Marta Gonzalez-Alvarez
Published 2021-09-01

Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola^® on the Luminal and Systemic Behavior of Loratadin...

by Bart Hens, Marival Bermejo, Rodrigo Cristofoletti, Gregory E. Amidon, Gordon L. Amidon
Published 2020-06-01

Classification of WHO Essential Oral Medicines for Children Applying a Provisional Pediatric Biopharmaceutics Classification System

by Jose-Manuel delMoral-Sanchez, Isabel Gonzalez-Alvarez, Marta Gonzalez-Alvarez, Andres Navarro, Marival Bermejo
Published 2019-10-01

Availability of Authorizations from EMA and FDA for Age-Appropriate Medicines Contained in the WHO Essential Medicines List for Children 2019

by Jose-Manuel delMoral-Sanchez, Isabel Gonzalez-Alvarez, Marta Gonzalez-Alvarez, Andres Navarro-Ruiz, Marival Bermejo
Published 2020-04-01

In Vivo Predictive Dissolution (IPD) for Carbamazepine Formulations: Additional Evidence Regarding a Biopredictive Dissolution Medium

by Marival Bermejo, Jessica Meulman, Marcelo Gomes Davanço, Patricia de Oliveira Carvalho, Isabel Gonzalez-Alvarez, Daniel Rossi Campos
Published 2020-06-01

A Mechanistic Physiologically-Based Biopharmaceutics Modeling (PBBM) Approach to Assess the In Vivo Performance of an Orally Administered Drug Product: From IVIVC to IVIVP

by Marival Bermejo, Bart Hens, Joseph Dickens, Deanna Mudie, Paulo Paixão, Yasuhiro Tsume, Kerby Shedden, Gordon L. Amidon
Published 2020-01-01

Biomimetic Artificial Membrane Permeability Assay over Franz Cell Apparatus Using BCS Model Drugs

by Leonardo de Souza Teixeira, Tatiana Vila Chagas, Antonio Alonso, Isabel Gonzalez-Alvarez, Marival Bermejo, James Polli, Kênnia Rocha Rezende
Published 2020-10-01

Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic Drugs

by Chiara Di Meo, Mayte Martínez-Martínez, Tommasina Coviello, Marival Bermejo, Virginia Merino, Isabel Gonzalez-Alvarez, Marta Gonzalez-Alvarez, Pietro Matricardi
Published 2018-11-01

Candesartan Cilexetil In Vitro–In Vivo Correlation: Predictive Dissolution as a Development Tool

by Andrés Figueroa-Campos, Bárbara Sánchez-Dengra, Virginia Merino, Arik Dahan, Isabel González-Álvarez, Alfredo García-Arieta, Marta González-Álvarez, Marival Bermejo
Published 2020-07-01

New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy

by Adrian H. Teruel, Isabel Gonzalez-Alvarez, Marival Bermejo, Virginia Merino, Maria Dolores Marcos, Felix Sancenon, Marta Gonzalez-Alvarez, Ramon Martinez-Mañez
Published 2020-09-01

Permeability Study of Polyphenols Derived from a Phenolic-Enriched Hibiscus sabdariffa Extract by UHPLC-ESI-UHR-Qq-TOF-MS

by Isabel Borrás-Linares, María Herranz-López, Enrique Barrajón-Catalán, David Arráez-Román, Isabel Gonzálezlvarez, Marival Bermejo, Alberto Fernández Gutiérrez, Vicente Micol, Antonio Segura-Carretero
Published 2015-08-01

Evaluation of the intestinal permeability of rosemary (Rosmarinus officinalis L.) extract polyphenols and terpenoids in Caco-2 cell monolayers.

by Almudena Pérez-Sánchez, Isabel Borrás-Linares, Enrique Barrajón-Catalán, David Arráez-Román, Isabel González-Álvarez, Elena Ibáñez, Antonio Segura-Carretero, Marival Bermejo, Vicente Micol
Published 2017-01-01

An In Vivo Predictive Dissolution Methodology (iPD Methodology) with a BCS Class IIb Drug Can Predict the In Vivo Bioequivalence Results: Etoricoxib Products

by Isabel Gonzalez-Alvarez, Marival Bermejo, Yasuhiro Tsume, Alejandro Ruiz-Picazo, Marta Gonzalez-Alvarez, Bart Hens, Alfredo Garcia-Arieta, Greg E. Amidon, Gordon L. Amidon
Published 2021-04-01

One and Two-Step In Vitro-In Vivo Correlations Based on USP IV Dynamic Dissolution Applied to Four Sodium Montelukast Products

by Mercedes Prieto-Escolar, Juan J. Torrado, Covadonga Álvarez, Alejandro Ruiz-Picazo, Marta Simón-Vázquez, Carlos Govantes, Jesús Frias, Alfredo García-Arieta, Isabel Gonzalez-Alvarez, Marival Bermejo
Published 2021-05-01

Intestinal Permeability Study of Clinically Relevant Formulations of Silibinin in Caco-2 Cell Monolayers

by Almudena Pérez-Sánchez, Elisabet Cuyàs, Verónica Ruiz-Torres, Luz Agulló-Chazarra, Sara Verdura, Isabel González-Álvarez, Marival Bermejo, Jorge Joven, Vicente Micol, Joaquim Bosch-Barrera, Javier A. Menendez
Published 2019-03-01

pH-Dependent Molecular Gate Mesoporous Microparticles for Biological Control of <i>Giardia intestinalis</i>

by Isabel González-Alvarez, Verónica Vivancos, Carmen Coll, Bárbara Sánchez-Dengra, Elena Aznar, Alejandro Ruiz-Picazo, Marival Bermejo, Félix Sancenón, María Auxiliadora Dea-Ayuela, Marta Gonzalez-Alvarez, Ramón Martínez-Máñez
Published 2021-01-01

Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses

by Marival Bermejo, Gislaine Kuminek, Jozef Al-Gousous, Alejandro Ruiz-Picazo, Yasuhiro Tsume, Alfredo Garcia-Arieta, Isabel González-Alvarez, Bart Hens, Gregory E. Amidon, Nair Rodriguez-Hornedo, Gordon L. Amidon, Deanna Mudie
Published 2019-03-01

Global testing of a consensus solubility assessment to enhance robustness of the WHO biopharmaceutical classification system

by Valeria Gigante, Giovanni M. Pauletti, Sabine Kopp, Minghze Xu, Isabel Gonzalez-Alvarez, Virginia Merino, Michelle P. McIntosh, Anita Wessels, Beom-Jin Lee, Kênnia Rocha Rezende, Gerhard K.E. Scriba, Gaurav P. S. Jadaun, Marival Bermejo
Published 2020-10-01