Molecular Changes in Dengue Envelope Protein Domain III upon Interaction with Glycosaminoglycans

by James G. Hyatt, Sylvain Prévost, Juliette M. Devos, Courtney J. Mycroft-West, Mark A. Skidmore, Anja Winter
Published 2020-11-01

A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence.

by Mark A Skidmore, Khairul Mohd Fadzli Mustaffa, Lynsay C Cooper, Scott E Guimond, Edwin A Yates, Alister G Craig
Published 2017-01-01

A Glycosaminoglycan Extract from <i>Portunus pelagicus</i> Inhibits BACE1, the β Secretase Implicated in Alzheimer’s Disease

by Courtney J. Mycroft-West, Lynsay C. Cooper, Anthony J. Devlin, Patricia Procter, Scott E. Guimond, Marco Guerrini, David G. Fernig, Marcelo A. Lima, Edwin A. Yates, Mark A. Skidmore
Published 2019-05-01

Glycosaminoglycans from <i>Litopenaeus vannamei</i> Inhibit the Alzheimer’s Disease β Secretase, BACE1

by Courtney J. Mycroft-West, Anthony J. Devlin, Lynsay C. Cooper, Scott E. Guimond, Patricia Procter, Marco Guerrini, Gavin J. Miller, David G. Fernig, Edwin A. Yates, Marcelo A. Lima, Mark A. Skidmore
Published 2021-04-01

Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain

by Zachariah P. Schuurs, Edward Hammond, Stefano Elli, Timothy R. Rudd, Courtney J. Mycroft-West, Marcelo A. Lima, Mark A. Skidmore, Richard Karlsson, Yen-Hsi Chen, Ieva Bagdonaite, Zhang Yang, Yassir A. Ahmed, Derek J. Richard, Jeremy Turnbull, Vito Ferro, Deirdre R. Coombe, Neha S. Gandhi
Published 2021-01-01

The Hyperlipidaemic Drug Fenofibrate Significantly Reduces Infection by SARS-CoV-2 in Cell Culture Models

by Scott P. Davies, Courtney J. Mycroft-West, Isabel Pagani, Harriet J. Hill, Yen-Hsi Chen, Richard Karlsson, Ieva Bagdonaite, Scott E. Guimond, Zania Stamataki, Marcelo Andrade De Lima, Jeremy E. Turnbull, Jeremy E. Turnbull, Zhang Yang, Elisa Vicenzi, Mark A. Skidmore, Farhat L. Khanim, Alan Richardson
Published 2021-08-01