RAB38 Facilitates Energy Metabolism and Counteracts Cell Death in Glioblastoma Cells

by Elena Bianchetti, Sierra J. Bates, Trang T. T. Nguyen, Markus D. Siegelin, Kevin A. Roth
Published 2021-06-01

Epigenetic Targeting of Mcl-1 Is Synthetically Lethal with Bcl-xL/Bcl-2 Inhibition in Model Systems of Glioblastoma

by Enyuan Shang, Trang T. T. Nguyen, Chang Shu, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin
Published 2020-08-01

Activation of LXR Receptors and Inhibition of TRAP1 Causes Synthetic Lethality in Solid Tumors

by Trang Thi Thu Nguyen, Chiaki Tsuge Ishida, Enyuan Shang, Chang Shu, Elena Bianchetti, Georg Karpel-Massler, Markus D. Siegelin
Published 2019-06-01

Cell-Penetrating CEBPB and CEBPD Leucine Zipper Decoys as Broadly Acting Anti-Cancer Agents

by Qing Zhou, Xiotian Sun, Nicolas Pasquier, Parvaneh Jefferson, Trang T. T. Nguyen, Markus D. Siegelin, James M. Angelastro, Lloyd A. Greene
Published 2021-05-01

Inhibition of HDAC1/2 Along with TRAP1 Causes Synthetic Lethality in Glioblastoma Model Systems

by Trang T. T. Nguyen, Yiru Zhang, Enyuan Shang, Chang Shu, Catarina M. Quinzii, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin
Published 2020-07-01

Dual Inhibition of Bcl-2/Bcl-xL and XPO1 is synthetically lethal in glioblastoma model systems

by Enyuan Shang, Yiru Zhang, Chang Shu, Chiaki Tsuge Ishida, Elena Bianchetti, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin
Published 2018-10-01

Temozolomide and Other Alkylating Agents in Glioblastoma Therapy

by Hannah Strobel, Tim Baisch, Rahel Fitzel, Katharina Schilberg, Markus D. Siegelin, Georg Karpel-Massler, Klaus-Michael Debatin, Mike-Andrew Westhoff
Published 2019-09-01

PARP inhibition restores extrinsic apoptotic sensitivity in glioblastoma.

by Georg Karpel-Massler, Fresia Pareja, Pascaline Aimé, Chang Shu, Lily Chau, Mike-Andrew Westhoff, Marc-Eric Halatsch, John F Crary, Peter Canoll, Markus D Siegelin
Published 2014-01-01

A Potential Role for the Inhibition of PI3K Signaling in Glioblastoma Therapy.

by Stephanie Ströbele, Matthias Schneider, Lukas Schneele, Markus D Siegelin, Lisa Nonnenmacher, Shaoxia Zhou, Georg Karpel-Massler, Mike-Andrew Westhoff, Marc-Eric Halatsch, Klaus-Michael Debatin
Published 2015-01-01

Inhibition of Bcl-2/Bcl-xL and c-MET causes synthetic lethality in model systems of glioblastoma

by Yiru Zhang, Chiaki Tsuge Ishida, Chang Shu, Giulio Kleiner, Maria J. Sanchez-Quintero, Elena Bianchetti, Catarina M. Quinzii, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin
Published 2018-05-01

Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL

by Georg Karpel-Massler, Chiaki Tsuge Ishida, Elena Bianchetti, Yiru Zhang, Chang Shu, Takashi Tsujiuchi, Matei A. Banu, Franklin Garcia, Kevin A. Roth, Jeffrey N. Bruce, Peter Canoll, Markus D. Siegelin
Published 2017-10-01

Considering the Experimental use of Temozolomide in Glioblastoma Research

by Verena J. Herbener, Timo Burster, Alicia Goreth, Maximilian Pruss, Hélène von Bandemer, Tim Baisch, Rahel Fitzel, Markus D. Siegelin, Georg Karpel-Massler, Klaus-Michael Debatin, Mike-Andrew Westhoff, Hannah Strobel
Published 2020-06-01

Activation of LXRβ inhibits tumor respiration and is synthetically lethal with Bcl‐xL inhibition

by Trang Thi Thu Nguyen, Chiaki Tsuge Ishida, Enyuan Shang, Chang Shu, Consuelo Torrini, Yiru Zhang, Elena Bianchetti, Maria J Sanchez‐Quintero, Giulio Kleiner, Catarina M Quinzii, Mike‐Andrew Westhoff, Georg Karpel‐Massler, Peter Canoll, Markus D Siegelin
Published 2019-10-01

Aurora kinase A inhibition reverses the Warburg effect and elicits unique metabolic vulnerabilities in glioblastoma

by Trang T. T. Nguyen, Enyuan Shang, Chang Shu, Sungsoo Kim, Angeliki Mela, Nelson Humala, Aayushi Mahajan, Hee Won Yang, Hasan Orhan Akman, Catarina M. Quinzii, Guoan Zhang, Mike-Andrew Westhoff, Georg Karpel-Massler, Jeffrey N. Bruce, Peter Canoll, Markus D. Siegelin
Published 2021-09-01