Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation

by Maxime J. Derisbourg, Laura E. Wester, Ruth Baddi, Martin S. Denzel
Published 2021-03-01

Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis

by Sabine Ruegenberg, Moritz Horn, Christian Pichlo, Kira Allmeroth, Ulrich Baumann, Martin S. Denzel
Published 2020-02-01

Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1

by Sabine Ruegenberg, Felix A. M. C. Mayr, Ilian Atanassov, Ulrich Baumann, Martin S. Denzel
Published 2021-04-01

Hexosamine Pathway Activation Improves Protein Homeostasis through the Integrated Stress Response

by Moritz Horn, Sarah I. Denzel, Balaji Srinivasan, Kira Allmeroth, Isabelle Schiffer, Vignesh Karthikaisamy, Stephan Miethe, Peter Breuer, Adam Antebi, Martin S. Denzel
Published 2020-03-01

miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to impact proteotoxicity and muscle function during aging

by Isabelle Schiffer, Birgit Gerisch, Kazuto Kawamura, Raymond Laboy, Jennifer Hewitt, Martin Sebastian Denzel, Marcelo A Mori, Siva Vanapalli, Yidong Shen, Orsolya Symmons, Adam Antebi
Published 2021-07-01

Oral Supplementation of Glucosamine Fails to Alleviate Acute Kidney Injury in Renal Ischemia-Reperfusion Damage.

by Marc Johnsen, Martin Richard Späth, Martin S Denzel, Heike Göbel, Torsten Kubacki, Karla Johanna Ruth Hoyer, Yvonne Hinze, Thomas Benzing, Bernhard Schermer, Adam Antebi, Volker Burst, Roman-Ulrich Müller
Published 2016-01-01

NHR-8 and P-glycoproteins uncouple xenobiotic resistance from longevity in chemosensory C. elegans mutants

by Gabriel A Guerrero, Maxime J Derisbourg, Felix AMC Mayr, Laura E Wester, Marco Giorda, J Eike Dinort, Matías D Hartman, Klara Schilling, María José Alonso-De Gennaro, Ryan J Lu, Bérénice A Benayoun, Martin S Denzel
Published 2021-08-01