Protein Crystallography in Vaccine Research and Development

by Enrico Malito, Andrea Carfi, Matthew J. Bottomley
Published 2015-06-01

The Role of the Immune System in Cutaneous Squamous Cell Carcinoma

by Matthew J. Bottomley, Jason Thomson, Catherine Harwood, Irene Leigh
Published 2019-04-01

Self-assembling protein nanoparticles in the design of vaccines

by Jacinto López-Sagaseta, Enrico Malito, Rino Rappuoli, Matthew J. Bottomley
Published 2016-01-01

Apo, Zn2+-bound and Mn2+-bound structures reveal ligand-binding properties of SitA from the pathogen Staphylococcus pseudintermedius

by Francesca Abate, Enrico Malito, Roberta Cozzi, Paola Lo Surdo, Domenico Maione, Matthew J. Bottomley
Published 2014-11-01

Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp

by Jacinto López-Sagaseta, Peter T. Beernink, Federica Bianchi, Laura Santini, Elisabetta Frigimelica, Alexander H. Lucas, Mariagrazia Pizza, Matthew J. Bottomley
Published 2018-02-01

Structure and assembly of group B streptococcus pilus 2b backbone protein.

by Roberta Cozzi, Enrico Malito, Maddalena Lazzarin, Annalisa Nuccitelli, Andrea Castagnetti, Matthew J Bottomley, Immaculada Margarit, Domenico Maione, C Daniela Rinaudo
Published 2015-01-01

Structures of NHBA elucidate a broadly conserved epitope identified by a vaccine induced antibody.

by Martina Maritan, Daniele Veggi, Roberta Cozzi, Lucia Dello Iacono, Erika Bartolini, Paola Lo Surdo, Giulietta Maruggi, Glen Spraggon, Matthew J Bottomley, Enrico Malito
Published 2018-01-01

Molecular Basis of Ligand-Dependent Regulation of NadR, the Transcriptional Repressor of Meningococcal Virulence Factor NadA.

by Alessia Liguori, Enrico Malito, Paola Lo Surdo, Luca Fagnocchi, Francesca Cantini, Andreas F Haag, Sébastien Brier, Mariagrazia Pizza, Isabel Delany, Matthew J Bottomley
Published 2016-04-01

Structural basis for group B streptococcus pilus 1 sortases C regulation and specificity.

by Roberta Cozzi, Daniil Prigozhin, Roberto Rosini, Francesca Abate, Matthew J Bottomley, Guido Grandi, John L Telford, C Daniela Rinaudo, Domenico Maione, Tom Alber
Published 2012-01-01

NadA3 Structures Reveal Undecad Coiled Coils and LOX1 Binding Regions Competed by Meningococcus B Vaccine-Elicited Human Antibodies

by Alessia Liguori, Lucia Dello Iacono, Giulietta Maruggi, Barbara Benucci, Marcello Merola, Paola Lo Surdo, Jacinto López-Sagaseta, Mariagrazia Pizza, Enrico Malito, Matthew J. Bottomley
Published 2018-10-01

4CMenB vaccine induces elite cross-protective human antibodies that compete with human factor H for binding to meningococcal fHbp.

by Daniele Veggi, Federica Bianchi, Laura Santini, Paola Lo Surdo, Chelsy C Chesterman, Werner Pansegrau, Nicoletta Bechi, Ying Huang, Vega Masignani, Mariagrazia Pizza, Rino Rappuoli, Matthew J Bottomley, Roberta Cozzi, Domenico Maione
Published 2020-10-01

The respiratory syncytial virus (RSV) prefusion F‐protein functional antibody repertoire in adult healthy donors

by Emanuele Andreano, Ida Paciello, Monia Bardelli, Simona Tavarini, Chiara Sammicheli, Elisabetta Frigimelica, Silvia Guidotti, Giulia Torricelli, Marco Biancucci, Ugo D’Oro, Sumana Chandramouli, Matthew J Bottomley, Rino Rappuoli, Oretta Finco, Francesca Buricchi
Published 2021-06-01

Structure, dynamics and immunogenicity of a catalytically inactive CXC chemokine-degrading protease SpyCEP from Streptococcus pyogenes

by Sophie McKenna, Enrico Malito, Sarah L. Rouse, Francesca Abate, Giuliano Bensi, Emiliano Chiarot, Francesca Micoli, Francesca Mancini, Danilo Gomes Moriel, Guido Grandi, Danuta Mossakowska, Max Pearson, Yingqi Xu, James Pease, Shiranee Sriskandan, Immaculada Margarit, Matthew J. Bottomley, Stephen Matthews
Published 2020-01-01

A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo1[S]

by Yan G. Ni, Stefania Di Marco, Jon H. Condra, Laurence B. Peterson, Weirong Wang, Fubao Wang, Shilpa Pandit, Holly A. Hammond, Ray Rosa, Richard T. Cummings, Dana D. Wood, Xiaomei Liu, Matthew J. Bottomley, Xun Shen, Rose M. Cubbon, Sheng-ping Wang, Douglas G. Johns, Cinzia Volpari, Lora Hamuro, Jayne Chin, Lingyi Huang, Jing Zhang Zhao, Salvatore Vitelli, Peter Haytko, Douglas Wisniewski, Lyndon J. Mitnaul, Carl P. Sparrow, Brian Hubbard, Andrea Carfí, Ayesha Sitlani
Published 2011-01-01