Pan-cancer analysis demonstrates that integrating polygenic risk scores with modifiable risk factors improves risk prediction

by Linda Kachuri, Rebecca E. Graff, Karl Smith-Byrne, Travis J. Meyers, Sara R. Rashkin, Elad Ziv, John S. Witte, Mattias Johansson
Published 2020-11-01

Diagnostic accuracy of age and alarm symptoms for upper GI malignancy in patients with dyspepsia in a GI clinic: a 7-year cross-sectional study.

by Hooman Khademi, Amir-Reza Radmard, Fatemeh Malekzadeh, Farin Kamangar, Siavosh Nasseri-Moghaddam, Mattias Johansson, Graham Byrnes, Paul Brennan, Reza Malekzadeh
Published 2012-01-01

Comparative feeding behaviour of native and introduced terrestrial snails tracks their ecological impacts

by Tedi Hoxha, Steve Crookes, Ian MacIsaac, Xuexiu Chang, Mattias Johansson, Jaimie T.A. Dick, Annegret Nicolai, Hugh J. MacIsaac
Published 2019-06-01

Circulating Concentrations of Vitamin B6 and Kidney Cancer Prognosis: A Prospective Case-Cohort Study.

by David C Muller, Mattias Johansson, David Zaridze, Anush Moukeria, Vladimir Janout, Ivana Holcatova, Marie Navratilova, Dana Mates, Øivind Midttun, Per Magne Ueland, Paul Brennan, Ghislaine Scelo
Published 2015-01-01

Common variation at 1q24.1 (ALDH9A1) is a potential risk factor for renal cancer.

by Marc Y R Henrion, Mark P Purdue, Ghislaine Scelo, Peter Broderick, Matthew Frampton, Alastair Ritchie, Angela Meade, Peng Li, James McKay, Mattias Johansson, Mark Lathrop, James Larkin, Nathaniel Rothman, Zhaoming Wang, Wong-Ho Chow, Victoria L Stevens, W Ryan Diver, Demetrius Albanes, Jarmo Virtamo, Paul Brennan, Timothy Eisen, Stephen Chanock, Richard S Houlston
Published 2015-01-01

Genetic variability of the mTOR pathway and prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).

by Daniele Campa, Anika Hüsing, Angelika Stein, Lucie Dostal, Heiner Boeing, Tobias Pischon, Anne Tjønneland, Nina Roswall, Kim Overvad, Jane Nautrup Østergaard, Laudina Rodríguez, Núria Sala, Maria-José Sánchez, Nerea Larrañaga, José María Huerta, Aurelio Barricarte, Kay-Tee Khaw, Nicholas Wareham, Ruth C Travis, Naomi E Allen, Pagona Lagiou, Antonia Trichopoulou, Dimitrios Trichopoulos, Domenico Palli, Sabina Sieri, Rosario Tumino, Carlotta Sacerdote, Henk van Kranen, H Bas Bueno-de-Mesquita, Göran Hallmans, Mattias Johansson, Isabelle Romieu, Mazda Jenab, David G Cox, Afshan Siddiq, Elio Riboli, Federico Canzian, Rudolf Kaaks
Published 2011-02-01

Pre-diagnostic metabolite concentrations and prostate cancer risk in 1077 cases and 1077 matched controls in the European Prospective Investigation into Cancer and Nutrition

by Julie A. Schmidt, Georgina K. Fensom, Sabina Rinaldi, Augustin Scalbert, Paul N. Appleby, David Achaintre, Audrey Gicquiau, Marc J. Gunter, Pietro Ferrari, Rudolf Kaaks, Tilman Kühn, Anna Floegel, Heiner Boeing, Antonia Trichopoulou, Pagona Lagiou, Eleutherios Anifantis, Claudia Agnoli, Domenico Palli, Morena Trevisan, Rosario Tumino, H. Bas Bueno-de-Mesquita, Antonio Agudo, Nerea Larrañaga, Daniel Redondo-Sánchez, Aurelio Barricarte, José Maria Huerta, J. Ramón Quirós, Nick Wareham, Kay-Tee Khaw, Aurora Perez-Cornago, Mattias Johansson, Amanda J. Cross, Konstantinos K. Tsilidis, Elio Riboli, Timothy J. Key, Ruth C. Travis
Published 2017-07-01

Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.

by Sara Lindstrom, Fredrick Schumacher, Afshan Siddiq, Ruth C Travis, Daniele Campa, Sonja I Berndt, W Ryan Diver, Gianluca Severi, Naomi Allen, Gerald Andriole, Bas Bueno-de-Mesquita, Stephen J Chanock, David Crawford, J Michael Gaziano, Graham G Giles, Edward Giovannucci, Carolyn Guo, Christopher A Haiman, Richard B Hayes, Jytte Halkjaer, David J Hunter, Mattias Johansson, Rudolf Kaaks, Laurence N Kolonel, Carmen Navarro, Elio Riboli, Carlotta Sacerdote, Meir Stampfer, Daniel O Stram, Michael J Thun, Dimitrios Trichopoulos, Jarmo Virtamo, Stephanie J Weinstein, Meredith Yeager, Brian Henderson, Jing Ma, Loic Le Marchand, Demetrius Albanes, Peter Kraft
Published 2011-02-01

Metabolic signatures of greater body size and their associations with risk of colorectal and endometrial cancers in the European Prospective Investigation into Cancer and Nutrition

by Nathalie Kliemann, Vivian Viallon, Neil Murphy, Rebecca J. Beeken, Joseph A. Rothwell, Sabina Rinaldi, Nada Assi, Eline H. van Roekel, Julie A. Schmidt, Kristin Benjaminsen Borch, Claudia Agnoli, Ann H. Rosendahl, Hanna Sartor, José María Huerta, Anne Tjønneland, Jytte Halkjær, Bas Bueno-de-Mesquita, Audrey Gicquiau, David Achaintre, Krasimira Aleksandrova, Matthias B. Schulze, Alicia K. Heath, Konstantinos K. Tsilidis, Giovanna Masala, Salvatore Panico, Rudolf Kaaks, Renée T. Fortner, Bethany Van Guelpen, Laure Dossus, Augustin Scalbert, Hector C. Keun, Ruth C. Travis, Mazda Jenab, Mattias Johansson, Pietro Ferrari, Marc J. Gunter
Published 2021-04-01

Epidemiology of 40 blood biomarkers of one-carbon metabolism, vitamin status, inflammation, and renal and endothelial function among cancer-free older adults

by Hana Zahed, Mattias Johansson, Per M. Ueland, Øivind Midttun, Roger L. Milne, Graham G. Giles, Jonas Manjer, Malte Sandsveden, Arnulf Langhammer, Elin Pettersen Sørgjerd, Kjell Grankvist, Mikael Johansson, Neal D. Freedman, Wen-Yi Huang, Chu Chen, Ross Prentice, Victoria L. Stevens, Ying Wang, Loic Le Marchand, Lynne R. Wilkens, Stephanie J. Weinstein, Demetrius Albanes, Qiuyin Cai, William J. Blot, Alan A. Arslan, Anne Zeleniuch-Jacquotte, Xiao-Ou Shu, Wei Zheng, Jian-Min Yuan, Woon-Puay Koh, Kala Visvanathan, Howard D. Sesso, Xuehong Zhang, J. Michael Gaziano, Anouar Fanidi, David Muller, Paul Brennan, Florence Guida, Hilary A. Robbins
Published 2021-07-01

Pleiotropy of genetic variants on obesity and smoking phenotypes: Results from the Oncoarray Project of The International Lung Cancer Consortium.

by Tao Wang, Jee-Young Moon, Yiqun Wu, Christopher I Amos, Rayjean J Hung, Adonina Tardon, Angeline Andrew, Chu Chen, David C Christiani, Demetrios Albanes, Erik H F M van der Heijden, Eric Duell, Gadi Rennert, Gary Goodman, Geoffrey Liu, James D Mckay, Jian-Min Yuan, John K Field, Jonas Manjer, Kjell Grankvist, Lambertus A Kiemeney, Loic Le Marchand, M Dawn Teare, Matthew B Schabath, Mattias Johansson, Melinda C Aldrich, Michael Davies, Mikael Johansson, Ming-Sound Tsao, Neil Caporaso, Philip Lazarus, Stephen Lam, Stig E Bojesen, Susanne Arnold, Xifeng Wu, Xuchen Zong, Yun-Chul Hong, Gloria Y F Ho
Published 2017-01-01

Circulating Metabolites Associated with Alcohol Intake in the European Prospective Investigation into Cancer and Nutrition Cohort

by Eline H. van Roekel, Laura Trijsburg, Nada Assi, Marion Carayol, David Achaintre, Neil Murphy, Sabina Rinaldi, Julie A. Schmidt, Magdalena Stepien, Rudolf Kaaks, Tilman Kühn, Heiner Boeing, Khalid Iqbal, Domenico Palli, Vittorio Krogh, Rosario Tumino, Fulvio Ricceri, Salvatore Panico, Petra H. Peeters, Bas Bueno-de-Mesquita, Eva Ardanaz, Leila Lujan-Barroso, J. Ramón Quirós, José M. Huerta, Elena Molina-Portillo, Miren Dorronsoro, Konstantinos K. Tsilidis, Elio Riboli, Agnetha Linn Rostgaard-Hansen, Anne Tjønneland, Kim Overvad, Elisabete Weiderpass, Marie-Christine Boutron-Ruault, Gianluca Severi, Antonia Trichopoulou, Anna Karakatsani, Anastasia Kotanidou, Anders Håkansson, Johan Malm, Matty P. Weijenberg, Marc J. Gunter, Mazda Jenab, Mattias Johansson, Ruth C. Travis, Augustin Scalbert, Pietro Ferrari
Published 2018-05-01

A New Pipeline for the Normalization and Pooling of Metabolomics Data

by Vivian Viallon, Mathilde His, Sabina Rinaldi, Marie Breeur, Audrey Gicquiau, Bertrand Hemon, Kim Overvad, Anne Tjønneland, Agnetha Linn Rostgaard-Hansen, Joseph A. Rothwell, Lucie Lecuyer, Gianluca Severi, Rudolf Kaaks, Theron Johnson, Matthias B. Schulze, Domenico Palli, Claudia Agnoli, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, W. M. Monique Verschuren, Peter Engelfriet, Charlotte Onland-Moret, Roel Vermeulen, Therese Haugdahl Nøst, Ilona Urbarova, Raul Zamora-Ros, Miguel Rodriguez-Barranco, Pilar Amiano, José Maria Huerta, Eva Ardanaz, Olle Melander, Filip Ottoson, Linda Vidman, Matilda Rentoft, Julie A. Schmidt, Ruth C. Travis, Elisabete Weiderpass, Mattias Johansson, Laure Dossus, Mazda Jenab, Marc J. Gunter, Justo Lorenzo Bermejo, Dominique Scherer, Reza M. Salek, Pekka Keski-Rahkonen, Pietro Ferrari
Published 2021-09-01

Using prior information from the medical literature in GWAS of oral cancer identifies novel susceptibility variant on chromosome 4--the AdAPT method.

by Mattias Johansson, Angus Roberts, Dan Chen, Yaoyong Li, Manon Delahaye-Sourdeix, Niraj Aswani, Mark A Greenwood, Simone Benhamou, Pagona Lagiou, Ivana Holcátová, Lorenzo Richiardi, Kristina Kjaerheim, Antonio Agudo, Xavier Castellsagué, Tatiana V Macfarlane, Luigi Barzan, Cristina Canova, Nalin S Thakker, David I Conway, Ariana Znaor, Claire M Healy, Wolfgang Ahrens, David Zaridze, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska, Eleonóra Fabiánová, Ioan Nicolae Mates, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Maria Paula Curado, Sergio Koifman, Ana Menezes, Victor Wünsch-Filho, Jose Eluf-Neto, Paolo Boffetta, Silvia Franceschi, Rolando Herrero, Leticia Fernandez Garrote, Renato Talamini, Stefania Boccia, Pilar Galan, Lars Vatten, Peter Thomson, Diana Zelenika, Mark Lathrop, Graham Byrnes, Hamish Cunningham, Paul Brennan, Jon Wakefield, James D McKay
Published 2012-01-01

Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility

by Linda Kachuri, Mattias Johansson, Sara R. Rashkin, Rebecca E. Graff, Yohan Bossé, Venkata Manem, Neil E. Caporaso, Maria Teresa Landi, David C. Christiani, Paolo Vineis, Geoffrey Liu, Ghislaine Scelo, David Zaridze, Sanjay S. Shete, Demetrius Albanes, Melinda C. Aldrich, Adonina Tardón, Gad Rennert, Chu Chen, Gary E. Goodman, Jennifer A. Doherty, Heike Bickeböller, John K. Field, Michael P. Davies, M. Dawn Teare, Lambertus A. Kiemeney, Stig E. Bojesen, Aage Haugen, Shanbeh Zienolddiny, Stephen Lam, Loïc Le Marchand, Iona Cheng, Matthew B. Schabath, Eric J. Duell, Angeline S. Andrew, Jonas Manjer, Philip Lazarus, Susanne Arnold, James D. McKay, Nima C. Emami, Matthew T. Warkentin, Yonathan Brhane, Ma’en Obeidat, Richard M. Martin, Caroline Relton, George Davey Smith, Philip C. Haycock, Christopher I. Amos, Paul Brennan, John S. Witte, Rayjean J. Hung
Published 2020-01-01

The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract.

by Manon Delahaye-Sourdeix, Javier Oliver, Maria N Timofeeva, Valérie Gaborieau, Mattias Johansson, Amélie Chabrier, Magdalena B Wozniak, Darren R Brenner, Maxime P Vallée, Devasena Anantharaman, Pagona Lagiou, Ivana Holcátová, Lorenzo Richiardi, Kristina Kjaerheim, Antonio Agudo, Xavier Castellsagué, Tatiana V Macfarlane, Luigi Barzan, Cristina Canova, Nalin S Thakker, David I Conway, Ariana Znaor, Claire M Healy, Wolfgang Ahrens, David Zaridze, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska, Eleonora Fabianova, Ioan Nicolae Mates, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Maria Paula Curado, Sergio Koifman, Ana Menezes, Victor Wünsch-Filho, José Eluf-Neto, Paolo Boffetta, Leticia Fernández Garrote, Diego Serraino, Marcin Lener, Ewa Jaworowska, Jan Lubiński, Stefania Boccia, Thangarajan Rajkumar, Tanuja A Samant, Manoj B Mahimkar, Keitaro Matsuo, Silvia Franceschi, Graham Byrnes, Paul Brennan, James D McKay
Published 2015-01-01

Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers.

by Corina Lesseur, Aida Ferreiro-Iglesias, James D McKay, Yohan Bossé, Mattias Johansson, Valerie Gaborieau, Maria Teresa Landi, David C Christiani, Neil C Caporaso, Stig E Bojesen, Christopher I Amos, Sanjay Shete, Geoffrey Liu, Gadi Rennert, Demetrius Albanes, Melinda C Aldrich, Adonina Tardon, Chu Chen, Liloglou Triantafillos, John K Field, Marion Dawn Teare, Lambertus A Kiemeney, Brenda Diergaarde, Robert L Ferris, Shanbeh Zienolddiny, Stephen Lam, Andrew F Olshan, Mark C Weissler, Martin Lacko, Angela Risch, Heike Bickeböller, Andy R Ness, Steve Thomas, Loic Le Marchand, Matthew B Schabath, Victor Wünsch-Filho, Eloiza H Tajara, Angeline S Andrew, Gary M Clifford, Philip Lazarus, Kjell Grankvist, Mikael Johansson, Susanne Arnold, Olle Melander, Hans Brunnström, Stefania Boccia, Gabriella Cadoni, Wim Timens, Ma'en Obeidat, Xiangjun Xiao, Richard S Houlston, Rayjean J Hung, Paul Brennan
Published 2021-03-01

Obesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study.

by Robert Carreras-Torres, Mattias Johansson, Philip C Haycock, Kaitlin H Wade, Caroline L Relton, Richard M Martin, George Davey Smith, Demetrius Albanes, Melinda C Aldrich, Angeline Andrew, Susanne M Arnold, Heike Bickeböller, Stig E Bojesen, Hans Brunnström, Jonas Manjer, Irene Brüske, Neil E Caporaso, Chu Chen, David C Christiani, W Jay Christian, Jennifer A Doherty, Eric J Duell, John K Field, Michael P A Davies, Michael W Marcus, Gary E Goodman, Kjell Grankvist, Aage Haugen, Yun-Chul Hong, Lambertus A Kiemeney, Erik H F M van der Heijden, Peter Kraft, Mikael B Johansson, Stephen Lam, Maria Teresa Landi, Philip Lazarus, Loïc Le Marchand, Geoffrey Liu, Olle Melander, Sungshim L Park, Gad Rennert, Angela Risch, Eric B Haura, Ghislaine Scelo, David Zaridze, Anush Mukeriya, Milan Savić, Jolanta Lissowska, Beata Swiatkowska, Vladimir Janout, Ivana Holcatova, Dana Mates, Matthew B Schabath, Hongbing Shen, Adonina Tardon, M Dawn Teare, Penella Woll, Ming-Sound Tsao, Xifeng Wu, Jian-Min Yuan, Rayjean J Hung, Christopher I Amos, James McKay, Paul Brennan
Published 2017-01-01

Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity

by Aida Ferreiro-Iglesias, Corina Lesseur, James McKay, Rayjean J. Hung, Younghun Han, Xuchen Zong, David Christiani, Mattias Johansson, Xiangjun Xiao, Yafang Li, David C. Qian, Xuemei Ji, Geoffrey Liu, Neil Caporaso, Ghislaine Scelo, David Zaridze, Anush Mukeriya, Milica Kontic, Simona Ognjanovic, Jolanta Lissowska, Małgorzata Szołkowska, Beata Swiatkowska, Vladimir Janout, Ivana Holcatova, Ciprian Bolca, Milan Savic, Miodrag Ognjanovic, Stig Egil Bojesen, Xifeng Wu, Demetrios Albanes, Melinda C. Aldrich, Adonina Tardon, Ana Fernandez-Somoano, Guillermo Fernandez-Tardon, Loic Le Marchand, Gadi Rennert, Chu Chen, Jennifer Doherty, Gary Goodman, Heike Bickeböller, H-Erich Wichmann, Angela Risch, Albert Rosenberger, Hongbing Shen, Juncheng Dai, John K. Field, Michael Davies, Penella Woll, M. Dawn Teare, Lambertus A. Kiemeney, Erik H. F. M. van der Heijden, Jian-Min Yuan, Yun-Chul Hong, Aage Haugen, Shanbeh Zienolddiny, Stephen Lam, Ming-Sound Tsao, Mikael Johansson, Kjell Grankvist, Matthew B. Schabath, Angeline Andrew, Eric Duell, Olle Melander, Hans Brunnström, Philip Lazarus, Susanne Arnold, Stacey Slone, Jinyoung Byun, Ahsan Kamal, Dakai Zhu, Maria Teresa Landi, Christopher I. Amos, Paul Brennan
Published 2018-09-01

The influence of obesity-related factors in the etiology of renal cell carcinoma-A mendelian randomization study.

by Mattias Johansson, Robert Carreras-Torres, Ghislaine Scelo, Mark P Purdue, Daniela Mariosa, David C Muller, Nicolas J Timpson, Philip C Haycock, Kevin M Brown, Zhaoming Wang, Yuanqing Ye, Jonathan N Hofmann, Matthieu Foll, Valerie Gaborieau, Mitchell J Machiela, Leandro M Colli, Peng Li, Jean-Guillaume Garnier, Helene Blanche, Anne Boland, Laurie Burdette, Egor Prokhortchouk, Konstantin G Skryabin, Meredith Yeager, Sanja Radojevic-Skodric, Simona Ognjanovic, Lenka Foretova, Ivana Holcatova, Vladimir Janout, Dana Mates, Anush Mukeriya, Stefan Rascu, David Zaridze, Vladimir Bencko, Cezary Cybulski, Eleonora Fabianova, Viorel Jinga, Jolanta Lissowska, Jan Lubinski, Marie Navratilova, Peter Rudnai, Simone Benhamou, Geraldine Cancel-Tassin, Olivier Cussenot, Elisabete Weiderpass, Börje Ljungberg, Raviprakash Tumkur Sitaram, Christel Häggström, Fiona Bruinsma, Susan J Jordan, Gianluca Severi, Ingrid Winship, Kristian Hveem, Lars J Vatten, Tony Fletcher, Susanna C Larsson, Alicja Wolk, Rosamonde E Banks, Peter J Selby, Douglas F Easton, Gabriella Andreotti, Laura E Beane Freeman, Stella Koutros, Satu Männistö, Stephanie Weinstein, Peter E Clark, Todd L Edwards, Loren Lipworth, Susan M Gapstur, Victoria L Stevens, Hallie Carol, Matthew L Freedman, Mark M Pomerantz, Eunyoung Cho, Kathryn M Wilson, J Michael Gaziano, Howard D Sesso, Neal D Freedman, Alexander S Parker, Jeanette E Eckel-Passow, Wen-Yi Huang, Richard J Kahnoski, Brian R Lane, Sabrina L Noyes, David Petillo, Bin Tean Teh, Ulrike Peters, Emily White, Garnet L Anderson, Lisa Johnson, Juhua Luo, Julie Buring, I-Min Lee, Wong-Ho Chow, Lee E Moore, Timothy Eisen, Marc Henrion, James Larkin, Poulami Barman, Bradley C Leibovich, Toni K Choueiri, G Mark Lathrop, Jean-Francois Deleuze, Marc Gunter, James D McKay, Xifeng Wu, Richard S Houlston, Stephen J Chanock, Caroline Relton, J Brent Richards, Richard M Martin, George Davey Smith, Paul Brennan
Published 2019-01-01