Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma

by Shunya Ohmura, Aruna Marchetto, Martin F. Orth, Jing Li, Susanne Jabar, Andreas Ranft, Endrit Vinca, Katharina Ceranski, Martha J. Carreño-Gonzalez, Laura Romero-Pérez, Fabienne S. Wehweck, Julian Musa, Felix Bestvater, Maximilian M. L. Knott, Tilman L. B. Hölting, Wolfgang Hartmann, Uta Dirksen, Thomas Kirchner, Florencia Cidre-Aranaz, Thomas G. P. Grünewald
Published 2021-07-01

Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer

by Jing Li, Shunya Ohmura, Aruna Marchetto, Martin F. Orth, Roland Imle, Marlene Dallmayer, Julian Musa, Maximilian M. L. Knott, Tilman L. B. Hölting, Stefanie Stein, Cornelius M. Funk, Ana Sastre, Javier Alonso, Felix Bestvater, Merve Kasan, Laura Romero-Pérez, Wolfgang Hartmann, Andreas Ranft, Ana Banito, Uta Dirksen, Thomas Kirchner, Florencia Cidre-Aranaz, Thomas G. P. Grünewald
Published 2021-09-01

Publisher Correction: Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma

by Aruna Marchetto, Shunya Ohmura, Martin F. Orth, Maximilian M. L. Knott, Maria V. Colombo, Chiara Arrigoni, Victor Bardinet, David Saucier, Fabienne S. Wehweck, Jing Li, Stefanie Stein, Julia S. Gerke, Michaela C. Baldauf, Julian Musa, Marlene Dallmayer, Laura Romero-Pérez, Tilman L. B. Hölting, James F. Amatruda, Andrea Cossarizza, Anton G. Henssen, Thomas Kirchner, Matteo Moretti, Florencia Cidre-Aranaz, Giuseppina Sannino, Thomas G. P. Grünewald
Published 2020-11-01

Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma

by Aruna Marchetto, Shunya Ohmura, Martin F. Orth, Maximilian M. L. Knott, Maria V. Colombo, Chiara Arrigoni, Victor Bardinet, David Saucier, Fabienne S. Wehweck, Jing Li, Stefanie Stein, Julia S. Gerke, Michaela C. Baldauf, Julian Musa, Marlene Dallmayer, Laura Romero-Pérez, Tilman L. B. Hölting, James F. Amatruda, Andrea Cossarizza, Anton G. Henssen, Thomas Kirchner, Matteo Moretti, Florencia Cidre-Aranaz, Giuseppina Sannino, Thomas G. P. Grünewald
Published 2020-05-01

High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma

by Martin F. Orth, Tilman L.B. Hölting, Marlene Dallmayer, Fabienne S. Wehweck, Tanja Paul, Julian Musa, Michaela C. Baldauf, Didier Surdez, Olivier Delattre, Maximilian M. L. Knott, Laura Romero-Pérez, Merve Kasan, Florencia Cidre-Aranaz, Julia S. Gerke, Shunya Ohmura, Jing Li, Aruna Marchetto, Anton G. Henssen, Özlem Özen, Shintaro Sugita, Tadashi Hasegawa, Takayuki Kanaseki, Stefanie Bertram, Uta Dirksen, Wolfgang Hartmann, Thomas Kirchner, Thomas G.P. Grünewald
Published 2020-03-01

Gene expression and immunohistochemical analyses identify SOX2 as major risk factor for overall survival and relapse in Ewing sarcoma patientsResearch in context

by Giuseppina Sannino, Aruna Marchetto, Andreas Ranft, Susanne Jabar, Constanze Zacherl, Rebeca Alba-Rubio, Stefanie Stein, Fabienne S. Wehweck, Merve M. Kiran, Tilman L.B. Hölting, Julian Musa, Laura Romero-Pérez, Florencia Cidre-Aranaz, Maximilian M.L. Knott, Jing Li, Heribert Jürgens, Ana Sastre, Javier Alonso, Willian Da Silveira, Gary Hardiman, Julia S. Gerke, Martin F. Orth, Wolfgang Hartmann, Thomas Kirchner, Shunya Ohmura, Uta Dirksen, Thomas G.P. Grünewald
Published 2019-09-01

Systematic identification of cancer-specific MHC-binding peptides with RAVEN

by Michaela C. Baldauf, Julia S. Gerke, Andreas Kirschner, Franziska Blaeschke, Manuel Effenberger, Kilian Schober, Rebeca Alba Rubio, Takayuki Kanaseki, Merve M. Kiran, Marlene Dallmayer, Julian Musa, Nurset Akpolat, Ayse N. Akatli, Fernando C. Rosman, Özlem Özen, Shintaro Sugita, Tadashi Hasegawa, Haruhiko Sugimura, Daniel Baumhoer, Maximilian M. L. Knott, Giuseppina Sannino, Aruna Marchetto, Jing Li, Dirk H. Busch, Tobias Feuchtinger, Shunya Ohmura, Martin F. Orth, Uwe Thiel, Thomas Kirchner, Thomas G. P. Grünewald
Published 2018-09-01

Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes

by Julian Musa, Florencia Cidre-Aranaz, Marie-Ming Aynaud, Martin F. Orth, Maximilian M. L. Knott, Olivier Mirabeau, Gal Mazor, Mor Varon, Tilman L. B. Hölting, Sandrine Grossetête, Moritz Gartlgruber, Didier Surdez, Julia S. Gerke, Shunya Ohmura, Aruna Marchetto, Marlene Dallmayer, Michaela C. Baldauf, Stefanie Stein, Giuseppina Sannino, Jing Li, Laura Romero-Pérez, Frank Westermann, Wolfgang Hartmann, Uta Dirksen, Melissa Gymrek, Nathaniel D. Anderson, Adam Shlien, Barak Rotblat, Thomas Kirchner, Olivier Delattre, Thomas G. P. Grünewald
Published 2019-09-01