p21WAF1/Cip1 Regulation by hYSK1 Activates SP-1 Transcription Factor and Increases MMP-2 Expression under Hypoxic Conditions

by Mee-Hyun Lee, Joydeb Kumar Kundu, Bu Young Choi
Published 2019-01-01

Dasatinib Inhibits Lung Cancer Cell Growth and Patient Derived Tumor Growth in Mice by Targeting LIMK1

by Man Zhang, Jie Tian, Rui Wang, Mengqiu Song, Mengqiu Song, Ran Zhao, Ran Zhao, Hanyong Chen, Kangdong Liu, Kangdong Liu, Jung-Hyun Shim, Jung-Hyun Shim, Feng Zhu, Zigang Dong, Zigang Dong, Mee-Hyun Lee, Mee-Hyun Lee, Mee-Hyun Lee
Published 2020-12-01

A Small Molecule Antagonist of PD-1/PD-L1 Interactions Acts as an Immune Checkpoint Inhibitor for NSCLC and Melanoma Immunotherapy

by Yuanyuan Wang, Yuanyuan Wang, Tingxuan Gu, Tingxuan Gu, Xueli Tian, Xueli Tian, Wenwen Li, Ran Zhao, Ran Zhao, Wenqian Yang, Wenqian Yang, Quanli Gao, Tiepeng Li, Jung-Hyun Shim, Chengjuan Zhang, Kangdong Liu, Kangdong Liu, Mee-Hyun Lee, Mee-Hyun Lee, Mee-Hyun Lee
Published 2021-05-01

Implications of Genetic and Epigenetic Alterations of CDKN2A (p16INK4a) in Cancer

by Ran Zhao, Bu Young Choi, Mee-Hyun Lee, Ann M. Bode, Zigang Dong
Published 2016-06-01

PBK/TOPK: An Effective Drug Target with Diverse Therapeutic Potential

by Hai Huang, Mee-Hyun Lee, Kangdong Liu, Zigang Dong, Zeayoung Ryoo, Myoung Ok Kim
Published 2021-05-01

3-Deoxysappanchalcone Inhibits Skin Cancer Proliferation by Regulating T-Lymphokine-Activated Killer Cell-Originated Protein Kinase in vitro and in vivo

by Xiaorong Fu, Xiaorong Fu, Ran Zhao, Ran Zhao, Goo Yoon, Jung-Hyun Shim, Jung-Hyun Shim, Bu Young Choi, Fanxiang Yin, Fanxiang Yin, Fanxiang Yin, Beibei Xu, Beibei Xu, Kyle Vaughn Laster, Kangdong Liu, Kangdong Liu, Zigang Dong, Zigang Dong, Mee-Hyun Lee, Mee-Hyun Lee, Mee-Hyun Lee
Published 2021-03-01

Xanthohumol Inhibits the Growth of Keratin 18-Overexpressed Esophageal Squamous Cell Carcinoma in vitro and in vivo

by Shuying Yin, Shuying Yin, Mengqiu Song, Mengqiu Song, Ran Zhao, Ran Zhao, Xuejiao Liu, Xuejiao Liu, Woo Kyu Kang, Jeong Min Lee, Young Eun Kim, Chengjuan Zhang, Jung-Hyun Shim, Kangdong Liu, Kangdong Liu, Kangdong Liu, Zigang Dong, Zigang Dong, Zigang Dong, Mee-Hyun Lee, Mee-Hyun Lee, Mee-Hyun Lee
Published 2020-05-01

Alternative Options for Skin Cancer Therapy via Regulation of AKT and Related Signaling Pathways

by Sun-Young Hwang, Jung-Il Chae, Ah-Won Kwak, Mee-Hyun Lee, Jung-Hyun Shim
Published 2020-09-01

Picropodophyllotoxin, an Epimer of Podophyllotoxin, Causes Apoptosis of Human Esophageal Squamous Cell Carcinoma Cells Through ROS-Mediated JNK/P38 MAPK Pathways

by Ah-Won Kwak, Goo Yoon, Mee-Hyun Lee, Seung-Sik Cho, Jung-Hyun Shim, Jung-Il Chae
Published 2020-06-01

Deoxypodophyllotoxin, a Lignan from <i>Anthriscus sylvestris</i>, Induces Apoptosis and Cell Cycle Arrest by Inhibiting the EGFR Signaling Pathways in Esophageal Squamous Cell Carc...

by Ah-Won Kwak, Mee-Hyun Lee, Goo Yoon, Seung-Sik Cho, Joon-Seok Choi, Jung-Il Chae, Jung-Hyun Shim
Published 2020-09-01

Estrogen-related receptor alpha directly binds to p53 and cooperatively controls colon cancer growth through the regulation of mitochondrial biogenesis and function

by Humberto De Vitto, Joohyun Ryu, Ali Calderon-Aparicio, Josh Monts, Raja Dey, Abhijit Chakraborty, Mee-Hyun Lee, Ann M. Bode, Zigang Dong
Published 2020-12-01

Licochalcone D Induces ROS-Dependent Apoptosis in Gefitinib-Sensitive or Resistant Lung Cancer Cells by Targeting EGFR and MET

by Ha-Na Oh, Mee-Hyun Lee, Eunae Kim, Ah-Won Kwak, Goo Yoon, Seung-Sik Cho, Kangdong Liu, Jung-Il Chae, Jung-Hyun Shim
Published 2020-02-01

Retrochalcone Echinatin Triggers Apoptosis of Esophageal Squamous Cell Carcinoma via ROS- and ER Stress-Mediated Signaling Pathways

by Ah-Won Kwak, Joon-Seok Choi, Mee-Hyun Lee, Ha-Na Oh, Seung-Sik Cho, Goo Yoon, Kangdong Liu, Jung-Il Chae, Jung-Hyun Shim
Published 2019-11-01

The ginsenoside 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol induces autophagy and apoptosis in human melanoma via AMPK/JNK phosphorylation.

by Soouk Kang, Jong-Eun Kim, Nu Ry Song, Sung Keun Jung, Mee Hyun Lee, Jun Seong Park, Myeong-Hun Yeom, Ann M Bode, Zigang Dong, Ki Won Lee
Published 2014-01-01

Inhibiting breast cancer by targeting the thromboxane A2 pathway

by Haitao Li, Mee-Hyun Lee, Kangdong Liu, Ting Wang, Mengqiu Song, Yaping Han, Ke Yao, Hua Xie, Feng Zhu, Michael Grossmann, Margot P. Cleary, Wei Chen, Ann M. Bode, Zigang Dong
Published 2017-04-01

A Small Molecule Inhibitor of the β-Catenin-TCF4 Interaction Suppresses Colorectal Cancer Growth In Vitro and In Vivo

by Seung Ho Shin, Do Young Lim, Kanamata Reddy, Margarita Malakhova, Fangfang Liu, Ting Wang, Mengqiu Song, Hanyong Chen, Ki Beom Bae, Joohyun Ryu, Kangdong Liu, Mee-Hyun Lee, Ann M. Bode, Zigang Dong
Published 2017-11-01

Targeting AKT with costunolide suppresses the growth of colorectal cancer cells and induces apoptosis in vitro and in vivo

by Hai Huang, Song Park, Haibo Zhang, Sijun Park, Wookbong Kwon, Enugyung Kim, Xiujuan Zhang, Soyoung Jang, Duhak Yoon, Seong-Kyoon Choi, Jun-koo Yi, Sung-hyun Kim, Zigang Dong, Mee-hyun Lee, Zaeyoung Ryoo, Myoung Ok Kim
Published 2021-03-01

Costunolide Induces Apoptosis via the Reactive Oxygen Species and Protein Kinase B Pathway in Oral Cancer Cells

by Hai Huang, Jun-Koo Yi, Su-Geun Lim, Sijun Park, Haibo Zhang, Eungyung Kim, Soyoung Jang, Mee-Hyun Lee, Kangdong Liu, Ki-Rim Kim, Eun-Kyong Kim, Youngkyun Lee, Sung-Hyun Kim, Zae-Young Ryoo, Myoung Ok Kim
Published 2021-07-01

ERK1 phosphorylates Nanog to regulate protein stability and stem cell self-renewal

by Sung-Hyun Kim, Myoung Ok Kim, Yong-Yeon Cho, Ke Yao, Dong Joon Kim, Chul-Ho Jeong, Dong Hoon Yu, Ki Beom Bae, Eun Jin Cho, Sung Keun Jung, Mee Hyun Lee, Hanyong Chen, Jae Young Kim, Ann M. Bode, Zigang Dong
Published 2014-07-01