Elucidation of the Pathogenesis of Autoinflammatory Diseases Using iPS Cells

by Megumu K. Saito
Published 2021-02-01

Induced pluripotent stem cells representing Nakajo-Nishimura syndrome

by Nobuo Kanazawa, Fumiko Honda-Ozaki, Megumu K. Saito
Published 2019-05-01

Induced pluripotent stem cell-derived monocytic cell lines from a NOMID patient serve as a screening platform for modulating NLRP3 inflammasome activity.

by Ryosuke Seki, Akira Ohta, Akira Niwa, Yoshinori Sugimine, Haruna Naito, Tatsutoshi Nakahata, Megumu K Saito
Published 2020-01-01

Pluripotent stem cell model of early hematopoiesis in Down syndrome reveals quantitative effects of short-form GATA1 protein on lineage specification.

by Shiori Matsuo, Yoko Nishinaka-Arai, Yasuhiro Kazuki, Mitsuo Oshimura, Tatsutoshi Nakahata, Akira Niwa, Megumu K Saito
Published 2021-01-01

A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors.

by Akira Niwa, Toshio Heike, Katsutsugu Umeda, Koichi Oshima, Itaru Kato, Hiromi Sakai, Hirofumi Suemori, Tatsutoshi Nakahata, Megumu K Saito
Published 2011-01-01

Pluripotent stem cell‐based screening identifies CUDC‐907 as an effective compound for restoring the in vitro phenotype of Nakajo‐Nishimura syndrome

by Naoya Kase, Madoka Terashima, Akira Ohta, Akira Niwa, Fumiko Honda‐Ozaki, Yuri Kawasaki, Tatsutoshi Nakahata, Nobuo Kanazawa, Megumu K. Saito
Published 2021-03-01

Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations

by Janin Grajcarek, Jean Monlong, Yoko Nishinaka-Arai, Michiko Nakamura, Miki Nagai, Shiori Matsuo, David Lougheed, Hidetoshi Sakurai, Megumu K. Saito, Guillaume Bourque, Knut Woltjen
Published 2019-10-01

N-Acetylcysteine prevents amyloid-β secretion in neurons derived from human pluripotent stem cells with trisomy 21

by Hiromitsu Toshikawa, Akihiro Ikenaka, Li Li, Yoko Nishinaka-Arai, Akira Niwa, Akira Ashida, Yasuhiro Kazuki, Tatsutoshi Nakahata, Hiroshi Tamai, David W. Russell, Megumu K. Saito
Published 2021-08-01

Microarray analyses of otospheres derived from the cochlea in the inner ear identify putative transcription factors that regulate the characteristics of otospheres.

by Takehiro Iki, Michihiro Tanaka, Shin-Ichiro Kitajiri, Tomoko Kita, Yuri Kawasaki, Akifumi Mizukoshi, Wataru Fujibuchi, Takayuki Nakagawa, Tatsutoshi Nakahata, Juichi Ito, Koichi Omori, Megumu K Saito
Published 2017-01-01

Identification of hepatic niche harboring human acute lymphoblastic leukemic cells via the SDF-1/CXCR4 axis.

by Itaru Kato, Akira Niwa, Toshio Heike, Hisanori Fujino, Megumu K Saito, Katsutsugu Umeda, Hidefumi Hiramatsu, Mamoru Ito, Makiko Morita, Yoko Nishinaka, Souichi Adachi, Fumihiko Ishikawa, Tatsutoshi Nakahata
Published 2011-01-01

Modeling the Early Phenotype at the Neuromuscular Junction of Spinal Muscular Atrophy Using Patient-Derived iPSCs

by Michiko Yoshida, Shiho Kitaoka, Naohiro Egawa, Mayu Yamane, Ryunosuke Ikeda, Kayoko Tsukita, Naoki Amano, Akira Watanabe, Masafumi Morimoto, Jun Takahashi, Hajime Hosoi, Tatsutoshi Nakahata, Haruhisa Inoue, Megumu K. Saito
Published 2015-04-01

Generation of a human induced pluripotent stem cell line, BRCi001-A, derived from a patient with mucopolysaccharidosis type I

by Mika Suga, Takayuki Kondo, Keiko Imamura, Ran Shibukawa, Yasue Okanishi, Yukako Sagara, Kayoko Tsukita, Takako Enami, Mahoko Furujo, Kaoru Saijo, Yukio Nakamura, Mitsujiro Osawa, Megumu K. Saito, Shinya Yamanaka, Haruhisa Inoue
Published 2019-04-01

Robust and highly-efficient differentiation of functional monocytic cells from human pluripotent stem cells under serum- and feeder cell-free conditions.

by Masakatsu D Yanagimachi, Akira Niwa, Takayuki Tanaka, Fumiko Honda-Ozaki, Seiko Nishimoto, Yuuki Murata, Takahiro Yasumi, Jun Ito, Shota Tomida, Koichi Oshima, Isao Asaka, Hiroaki Goto, Toshio Heike, Tatsutoshi Nakahata, Megumu K Saito
Published 2013-01-01

Generation of two human induced pluripotent stem cell lines derived from two X-linked adrenoleukodystrophy patients with ABCD1 mutations

by Yuji Kuramochi, Tomonari Awaya, Mami Matsuo-Takasaki, Miho Takami, Yuri An, Jingyue Li, Yasuko Hemmi, Tamami Wakabayashi, Yutaka Arai, Jun Inoue, Michiya Noguchi, Yukio Nakamura, Isao Asaka, Kazunori Akimoto, Megumu K. Saito, Yohei Hayashi
Published 2021-05-01

Author Correction: Pluripotent stem cell model of Shwachman–Diamond syndrome reveals apoptotic predisposition of hemoangiogenic progenitors

by Takayuki Hamabata, Katsutsugu Umeda, Kagehiro Kouzuki, Takayuki Tanaka, Tomoo Daifu, Seishiro Nodomi, Satoshi Saida, Itaru Kato, Shiro Baba, Hidefumi Hiramatsu, Mitsujiro Osawa, Akira Niwa, Megumu K. Saito, Yasuhiko Kamikubo, Souichi Adachi, Yoshiko Hashii, Akira Shimada, Hiroyoshi Watanabe, Kenji Osafune, Keisuke Okita, Tatsutoshi Nakahata, Kenichiro Watanabe, Junko Takita, Toshio Heike
Published 2021-01-01