Altering Nitrogen Heterocycles of AZD2461 Affords High Affinity Poly(ADP-ribose) Polymerase‑1 Inhibitors with Decreased P‑Glycoprotein Interactions

by Sean W. Reilly, Laura N. Puentes, Chia-Ju Hsieh, Mehran Makvandi, Robert H. Mach
Published 2018-08-01

PARP Theranostic Auger Emitters Are Cytotoxic in BRCA Mutant Ovarian Cancer and Viable Tumors from Ovarian Cancer Patients Enable Ex-Vivo Screening of Tumor Response

by Aladdin Riad, Sarah B. Gitto, Hwan Lee, Harrison D. Winters, Paul M. Martorano, Chia-Ju Hsieh, Kuiying Xu, Dalia K. Omran, Daniel J. Powell, Robert H. Mach, Mehran Makvandi
Published 2020-12-01